{
  "id": 19266,
  "label": "AA amyloidosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019439",
  "properties": {
    "xrefs": [
      "DOID:0080936",
      "GARD:0010560",
      "ICD9:277.39",
      "MEDGEN:782429",
      "MedDRA:10039811",
      "NCIT:C3818",
      "Orphanet:85445",
      "SCTID:281034005",
      "UMLS:C3536715",
      "icd11.foundation:570181034"
    ],
    "synonyms": [
      "inflammatory amyloidosis",
      "reactive amyloidosis",
      "secondary amyloidosis",
      "amyloid A amyloidosis",
      "amyloidosis AA"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Secondary amyloidosis is a form of amyloidosis, that complicates chronic inflammatory disorders (mainly rheumatoid arthritis) and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. Although spleen, suprarenal gland, liver and gut are frequent sites of amyloid deposition, the clinical picture is dominated by renal involvement."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6799,
      "label": "nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:863",
          "EFO:0000618",
          "ICD10CM:G00-G99",
          "ICD9:349.89",
          "ICD9:349.9",
          "MEDGEN:14336",
          "MESH:D009422",
          "NCIT:C26835",
          "SCTID:118940003",
          "UMLS:C0027765",
          "Wikipedia:Nervous_system_disease"
        ],
        "synonyms": [
          "disease of nervous system",
          "disease or disorder of nervous system",
          "disorder of nervous system",
          "nervous system disease",
          "nervous system disease or disorder",
          "nervous system disorder",
          "neurologic disease",
          "neurologic disorder",
          "neurological disease",
          "neurological disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005071"
    },
    {
      "id": 16883,
      "label": "non-familial restrictive cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020535",
          "MEDGEN:1843079",
          "NANDO:1200294",
          "Orphanet:217720",
          "UMLS:C5680885",
          "icd11.foundation:2097520643"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 7,
      "reference_id": "MONDO:0016345"
    },
    {
      "id": 18960,
      "label": "amyloidosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20409
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9120",
          "EFO:1001875",
          "GARD:0018676",
          "HP:0011034",
          "ICD10CM:E85",
          "ICD10WHO:E85",
          "ICD9:277.3",
          "ICD9:277.30",
          "MEDGEN:272",
          "MESH:D000686",
          "MedDRA:10002022",
          "NANDO:2200138",
          "NCIT:C2868",
          "ONCOTREE:MIDDA",
          "Orphanet:69",
          "SCTID:17602002",
          "UMLS:C0002726",
          "icd11.foundation:2078467774"
        ],
        "synonyms": [
          "amyloid",
          "amyloid disease",
          "amyloidoses",
          "amyloidosis",
          "amyloidosis (disease)"
        ],
        "definition": "A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands."
      },
      "child_count": 12,
      "reference_id": "MONDO:0019065"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6799,
      "label": "nervous system disorder"
    },
    {
      "id": 16883,
      "label": "non-familial restrictive cardiomyopathy"
    },
    {
      "id": 18960,
      "label": "amyloidosis"
    }
  ]
}