{
  "id": 19273,
  "label": "atypical lichen myxedematosus",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019447",
  "properties": {
    "xrefs": [
      "GARD:0019066",
      "MEDGEN:1383234",
      "Orphanet:86797",
      "SCTID:725148000",
      "UMLS:C4510874"
    ],
    "synonyms": [
      "Intermediate lichen myxedematosus"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "Atypical lichen myxedematosus is an intermediate form of lichen myxedematosus (LM) (a form of mucin dermal deposit) which does not meet the criteria for either scleromyxedema or the localized form. Three clinical subtypes have been described and include scleromyxedema without monoclonal gammopathy; localized forms with monoclonal gammopathy and/or systemic symptoms; localized forms with mixed features of the 5 subtypes of localized LM (discrete form, acral persistent papular mucinosis, self-healing papular mucinosis, papular mucinosis of infancy, and a pure nodular form). The course of atypical LM is unpredictable because only a few cases have been reported."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 18480,
      "label": "lichen myxedematosus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4593,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021709",
          "ICD9:701.8",
          "MEDGEN:1848864",
          "Orphanet:402007",
          "SCTID:111197009",
          "UMLS:C5848049"
        ],
        "synonyms": [
          "lichen myxoedematosus",
          "lichenoid myxedema",
          "papular mucinosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0018432"
    }
  ],
  "children": [
    {
      "id": 19388,
      "label": "localized lichen myxedematosus with mixed features of different subtypes",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19273
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019142",
          "MEDGEN:1843441",
          "Orphanet:90398",
          "UMLS:C5681465"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Localized lichen myxedematosus (LM) with mixed features of different subtypes is a form of atypical lichen myxedematosus, characterized by mixed features of the 5 subtypes of localized LM which are: discrete papular LM, acral persistent papular mucinosis, self-healing papular mucinosis, papular mucinosis of infancy, and nodular LM."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019583"
    },
    {
      "id": 19389,
      "label": "localized lichen myxedematosus with monoclonal gammopathy or systemic symptoms",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19273
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019143",
          "MEDGEN:1843442",
          "Orphanet:90399",
          "UMLS:C5681466"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Localized lichen myxedematosus with monoclonal gammopathy or systemic symptoms is a form of atypical lichen myxedematosus, characterized by the appearance of several 2-4 mm erythematous waxy papules confined to a few sites that may be associated with either an immunoglobulin A (IgA) nephropathy in patients with acral persistent papular mucinosis; discrete papular lichen myxedematosus; a scleromyxedema-like involvement, with dysphagia, hoarseness, pulmonary involvement, and carpal tunnel syndrome; myositis without skin sclerosis; or paraproteinemia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019584"
    },
    {
      "id": 19390,
      "label": "scleromyxedema without monoclonal gammopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19273
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019144",
          "MEDGEN:1843341",
          "Orphanet:90400",
          "UMLS:C5681463"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Scleromyxedema without monoclonal gammopathy is a form of atypical lichen myxedematosus, characterized by a generalized sclerodermoid infiltration of skin studded with multiple, firm papules of 1-3 mm in diameter involving face (leonine appearance), trunk, and limbs, without monoclonal gammopathy. The involvement of the face can be missing and pruritus may be prominent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019585"
    }
  ],
  "roots": [
    {
      "id": 18480,
      "label": "lichen myxedematosus"
    }
  ]
}