{
  "id": 19285,
  "label": "acute leukemia of ambiguous lineage",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019460",
  "properties": {
    "xrefs": [
      "GARD:0008638",
      "MEDGEN:226983",
      "MedDRA:10067399",
      "NANDO:2200017",
      "NANDO:2200018",
      "NCIT:C7464",
      "Orphanet:86851",
      "SCTID:721308005",
      "UMLS:C1301357",
      "icd11.foundation:1062906118"
    ],
    "synonyms": [
      "acute leukaemia of indeterminate lineage",
      "acute leukemia of ambiguous lineage",
      "acute leukemia of indeterminate lineage",
      "hybrid acute leukaemia",
      "hybrid acute leukemia",
      "mixed lineage acute leukaemia",
      "mixed lineage acute leukemia",
      "ALL with myeloid markers",
      "AML with lymphoid markers",
      "BAL",
      "acute leukaemia of undetermined lineage",
      "acute leukemia of undetermined lineage",
      "biphenotypic acute leukaemia",
      "biphenotypic acute leukemia",
      "mixed phenotype acute leukaemia",
      "mixed phenotype acute leukemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells. (WHO, 2001)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 18806,
      "label": "acute myeloid leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6429,
        11789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9119",
          "EFO:0000222",
          "GARD:0012757",
          "ICD10CM:C92.0",
          "ICD9:205.0",
          "ICD9:205.00",
          "ICDO:9861/3",
          "MEDGEN:9730",
          "MESH:D015470",
          "MedDRA:10000880",
          "NCIT:C3171",
          "NORD:1905",
          "OMIM:601626",
          "ONCOTREE:AML",
          "Orphanet:519",
          "SCTID:91861009",
          "UMLS:C0023467"
        ],
        "synonyms": [
          "AML",
          "AML - acute myeloid leukaemia",
          "AML - acute myeloid leukemia",
          "ANLL",
          "acute Nonlymphocytic leukaemia",
          "acute Nonlymphocytic leukemia",
          "acute granulocytic leukaemia",
          "acute granulocytic leukemia",
          "acute myeloblastic leukemia",
          "acute myelocytic leukaemia",
          "acute myelocytic leukemia",
          "acute myelogenous leukemia",
          "acute myelogenous leukemias",
          "acute myeloid leukaemia (AML)",
          "acute myeloid leukemia",
          "acute myeloid leukemia (AML)",
          "acute myeloid leukemia, somatic",
          "acute nonlymphocytic leukaemia",
          "acute nonlymphocytic leukemia",
          "hematopoeitic - acute Myleogenous leukaemia (AML)",
          "hematopoeitic - acute Myleogenous leukemia (AML)",
          "leukemia, acute myeloid, autosomal dominant, somatic mutation",
          "leukemia, acute myeloid, reduced survival in, somatic",
          "leukemia, acute myeloid, somatic",
          "leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation",
          "leukemia, myelocytic, acute",
          "myeloid leukemia, acute",
          "myeloid leukemia, acute, M4/M4Eo subtype, somatic",
          "acute non lymphoblastic leukaemia",
          "acute non lymphoblastic leukemia",
          "leukemia, acute myelogenous",
          "leukemia, acute myeloid",
          "leukemia, acute myeloid, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections."
      },
      "child_count": 156,
      "reference_id": "MONDO:0018874"
    }
  ],
  "children": [
    {
      "id": 12242,
      "label": "bilineal acute myeloid leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19285
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024773",
          "MEDGEN:87614",
          "NCIT:C6923",
          "Orphanet:98836",
          "UMLS:C0349680"
        ],
        "synonyms": [
          "acute bilineal leukaemia",
          "acute bilineal leukemia",
          "bilineal acute leukaemia",
          "bilineal acute leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute leukemia of ambiguous lineage in which there is a dual population of blasts with each population expressing markers of a distinct lineage (myeloid and lymphoid or B-and T-lymphocyte). (WHO, 2001) -- 2003"
      },
      "child_count": 0,
      "reference_id": "MONDO:0011118"
    },
    {
      "id": 19794,
      "label": "acute undifferentiated leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19285
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016863",
          "MEDGEN:79081",
          "MedDRA:10045516",
          "NANDO:2200017",
          "NCIT:C9298",
          "ONCOTREE:AUL",
          "Orphanet:98835",
          "SCTID:359631009",
          "UMLS:C0280141"
        ],
        "synonyms": [
          "acute myeloid leukemia, minimal differentiation, FAB M0",
          "acute undifferentiated leukemia",
          "leukaemia stem cell",
          "leukemia stem cell",
          "stem cell acute leukaemia",
          "stem cell acute leukemia",
          "stem cell leukaemia",
          "stem cell leukemia",
          "undifferentiated acute leukaemia",
          "undifferentiated acute leukemia",
          "AUL",
          "acute leukaemia not otherwise specified"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare acute leukemia of ambiguous lineage in which the blasts do not express markers specific to myeloid or lymphoid lineage."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020321"
    },
    {
      "id": 20146,
      "label": "mixed phenotype acute leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19285
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017972",
          "MEDGEN:417342",
          "MedDRA:10067399",
          "NANDO:2200018",
          "NCIT:C82179",
          "Orphanet:530995",
          "UMLS:C2826025"
        ],
        "synonyms": [
          "MPAL",
          "mixed phenotype acute leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute leukemia of ambiguous lineage. It is characterized by the presence of either separate populations of blasts of more than one lineage, or one population of blasts co-expressing markers of more than one lineage."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020743"
    }
  ],
  "roots": [
    {
      "id": 18806,
      "label": "acute myeloid leukemia"
    }
  ]
}