{
  "id": 19286,
  "label": "B-cell prolymphocytic leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019461",
  "properties": {
    "xrefs": [
      "DOID:0081041",
      "EFO:1000102",
      "GARD:0008223",
      "ICDO:9833/3",
      "MEDGEN:105396",
      "MESH:D054403",
      "NCIT:C4753",
      "ONCOTREE:BPLL",
      "Orphanet:86852",
      "SCTID:277619001",
      "UMLS:C0475801",
      "icd11.foundation:1997215876"
    ],
    "synonyms": [
      "B prolymphocytic leukaemia",
      "B prolymphocytic leukemia",
      "B-PLL",
      "B-cell prolymphocytic leukemia",
      "BPLL"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3282,
      "label": "prolymphocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        6710
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1039",
          "GARD:0011965",
          "ICD9:204.80",
          "ICDO:9832/3",
          "MEDGEN:6062",
          "MESH:D015463",
          "NCIT:C3181",
          "SCTID:110006004",
          "UMLS:C0023486"
        ],
        "synonyms": [
          "prolymphocytic leukaemia (B or T)",
          "prolymphocytic leukaemia (B or T-cell)",
          "prolymphocytic leukemia",
          "prolymphocytic leukemia (B or T)",
          "prolymphocytic leukemia (B or T-cell)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A mature B- or T- cell leukemia with progressive clinical course. It is characterized by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) in the peripheral blood, bone marrow, and spleen."
      },
      "child_count": 6,
      "reference_id": "MONDO:0001023"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:706",
          "EFO:0000096",
          "GARD:0024136",
          "ICD9:202.0",
          "MEDGEN:235305",
          "NCIT:C27910",
          "ONCOTREE:MBN",
          "SCTID:269476000",
          "UMLS:C1334633"
        ],
        "synonyms": [
          "mature B-cell lymphocytic neoplasm",
          "mature B-cell neoplasm",
          "mature B-cell neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004949"
    },
    {
      "id": 17875,
      "label": "aggressive B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021245",
          "MEDGEN:1791561",
          "NCIT:C178541",
          "Orphanet:300846",
          "UMLS:C5555120"
        ],
        "synonyms": [
          "aggressive B-cell NHL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0017595"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3282,
      "label": "prolymphocytic leukemia"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells"
    },
    {
      "id": 17875,
      "label": "aggressive B-cell non-Hodgkin lymphoma"
    }
  ]
}