{
  "id": 19290,
  "label": "nodal marginal zone B-cell lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019465",
  "properties": {
    "xrefs": [
      "DOID:0080211",
      "GARD:0019075",
      "MEDGEN:208959",
      "MedDRA:10029460",
      "NCIT:C8863",
      "ONCOTREE:NMZL",
      "Orphanet:86867",
      "SCTID:277623009",
      "UMLS:C0855139",
      "icd11.foundation:1720785883"
    ],
    "synonyms": [
      "Monocytoid B-cell lymphoma",
      "NMZL",
      "nodal marginal zone B-cell lymph.",
      "nodal marginal zone B-cell lymphoma",
      "nodal marginal zone lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Nodal marginal zone B-cell lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma, characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement of the lymph nodes, sometimes the bone marrow, and rarely the blood. Clinically it presents with disseminated peripheral, abdominal and/or thoracic lymphadenopathy. Cytopenia and bulky tumors (greater than 5 cm) are rare. Association with Hepatitis C virus and chronic inflammation has been reported."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17884,
      "label": "marginal zone lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17874,
        22946
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050748",
          "EFO:1000630",
          "GARD:0013237",
          "ICDO:9699/3",
          "MEDGEN:277950",
          "NCIT:C4341",
          "ONCOTREE:MZL",
          "Orphanet:300912",
          "SCTID:447100004",
          "UMLS:C1367654"
        ],
        "synonyms": [
          "MZBCL",
          "MZL",
          "lymphoma of marginal zone B cell",
          "marginal zone B cell lymphoma",
          "marginal zone B-cell lymphoma",
          "marginal zone lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood."
      },
      "child_count": 8,
      "reference_id": "MONDO:0017604"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17884,
      "label": "marginal zone lymphoma"
    }
  ]
}