{
  "id": 19293,
  "label": "T-cell prolymphocytic leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019468",
  "properties": {
    "xrefs": [
      "DOID:0081042",
      "EFO:1000560",
      "GARD:0013731",
      "ICDO:9834/3",
      "MEDGEN:391707",
      "MESH:D015461",
      "MedDRA:10042985",
      "NCIT:C4752",
      "ONCOTREE:TPLL",
      "Orphanet:86871",
      "SCTID:277545003",
      "SCTID:277567002",
      "UMLS:C2363142",
      "icd11.foundation:352523899"
    ],
    "synonyms": [
      "CLL, T-cell",
      "T cell CLL",
      "T cell chronic lymphocytic leukaemia",
      "T cell chronic lymphocytic leukemia",
      "T cell prolymphocytic leukaemia",
      "T cell prolymphocytic leukemia",
      "T prolymphocytic leukaemia",
      "T prolymphocytic leukemia",
      "T-PLL",
      "T-cell CLL",
      "T-cell chronic lymphocytic leukaemia",
      "T-cell chronic lymphocytic leukemia",
      "T-cell prolymphocytic leukemia",
      "chronic T-cell leukaemia",
      "chronic T-cell leukemia",
      "chronic T-cell lymphocytic leukaemia",
      "chronic T-cell lymphocytic leukemia",
      "TPLL",
      "leukemia, T-cell, chronic"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A slow-growing type of leukemia (blood cancer) in which too many lymphocytes are found in the bone marrow and/or blood. The T-cell is specified as the defective cell line."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6891,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050743",
          "DOID:0050749",
          "GARD:0007368",
          "ICD10CM:C84.4",
          "ICDO:9702/3",
          "MEDGEN:1790498",
          "MESH:D016411",
          "NCIT:C3468",
          "SCTID:109977009",
          "UMLS:C5551485"
        ],
        "synonyms": [
          "PTCL",
          "mature T-and NK-cell lymphoma",
          "mature T-cell and NK-cell lymphoma",
          "mature T-cell and NK-cell non-Hodgkin lymphoma",
          "mature T-cell and NK-cell non-Hodgkin's lymphoma",
          "mature T-cell lymphoma",
          "mature T-cell non-Hodgkin's lymphoma",
          "peripheral T-cell lymphoma",
          "NK-T cell lymphoma",
          "mature T-cell and natural killer cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature T- and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000430"
    },
    {
      "id": 3282,
      "label": "prolymphocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        6710
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1039",
          "GARD:0011965",
          "ICD9:204.80",
          "ICDO:9832/3",
          "MEDGEN:6062",
          "MESH:D015463",
          "NCIT:C3181",
          "SCTID:110006004",
          "UMLS:C0023486"
        ],
        "synonyms": [
          "prolymphocytic leukaemia (B or T)",
          "prolymphocytic leukaemia (B or T-cell)",
          "prolymphocytic leukemia",
          "prolymphocytic leukemia (B or T)",
          "prolymphocytic leukemia (B or T-cell)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A mature B- or T- cell leukemia with progressive clinical course. It is characterized by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) in the peripheral blood, bone marrow, and spleen."
      },
      "child_count": 6,
      "reference_id": "MONDO:0001023"
    },
    {
      "id": 5443,
      "label": "T lymphoblastic leukemia/lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5444,
        21530
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5599",
          "GARD:0023552",
          "ICDO:9837/3",
          "MEDGEN:224897",
          "NCIT:C8694",
          "UMLS:C1301359"
        ],
        "synonyms": [
          "precursor T lymphoblastic leukemia/lymphoma",
          "precursor T lymphoblastic lymphoma/leukemia",
          "precursor T-lymphoblastic lymphoma/leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called T acute lymphoblastic leukemia. When it involves nodal or extranodal sites it is called T lymphoblastic lymphoma. (WHO, 2001)"
      },
      "child_count": 10,
      "reference_id": "MONDO:0003537"
    },
    {
      "id": 6706,
      "label": "T-cell acute lymphoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6710,
        7179
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2004-1600",
          "CSP:2004-1803",
          "DOID:5603",
          "EFO:0000209",
          "GARD:0024138",
          "HGNC:5056",
          "ICDO:9837/3",
          "MEDGEN:368378",
          "NANDO:2200003",
          "NCIT:C3183",
          "SCTID:277575008",
          "UMLS:C1961099"
        ],
        "synonyms": [
          "acute T cell leukaemia",
          "T acute lymphoblastic leukaemia",
          "T acute lymphoblastic leukemia",
          "T-ALL",
          "T-cell ALL",
          "T-cell acute lymphoblastic leukaemia",
          "T-cell acute lymphoblastic leukemia",
          "T-cell acute lymphocytic leukemia",
          "T-cell type acute leukaemia",
          "T-cell type acute leukemia",
          "acute T cell leukemia",
          "acute T cell lymphoblastic leukaemia",
          "acute T cell lymphoblastic leukemia",
          "acute T cell lymphocytic leukaemia",
          "acute T cell lymphocytic leukemia",
          "acute T-cell leukaemia",
          "acute T-cell leukemia",
          "acute T-cell lymphoblastic leukaemia",
          "acute T-cell lymphoblastic leukemia",
          "acute T-cell lymphocytic leukaemia",
          "acute T-cell lymphocytic leukemia",
          "precursor T lymphoblastic leukaemia",
          "precursor T-lymphoblastic leukaemia",
          "precursor T-lymphoblastic leukaemia (T-cell ALL)",
          "precursor T-lymphoblastic leukemia",
          "precursor T-lymphoblastic leukemia (T-cell ALL)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females. (WHO, 2001)"
      },
      "child_count": 8,
      "reference_id": "MONDO:0004963"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma"
    },
    {
      "id": 3282,
      "label": "prolymphocytic leukemia"
    },
    {
      "id": 5443,
      "label": "T lymphoblastic leukemia/lymphoma"
    },
    {
      "id": 6706,
      "label": "T-cell acute lymphoblastic leukemia"
    }
  ]
}