{
  "id": 19294,
  "label": "T-cell large granular lymphocyte leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019469",
  "properties": {
    "xrefs": [
      "DOID:0050751",
      "GARD:0009812",
      "ICD9:204.80",
      "ICDO:9768/1",
      "ICDO:9831/1",
      "ICDO:9831/3",
      "MEDGEN:363038",
      "MedDRA:10065862",
      "NCIT:C4664",
      "ONCOTREE:TLGL",
      "Orphanet:86872",
      "SCTID:277569004",
      "UMLS:C1955861",
      "icd11.foundation:83430037"
    ],
    "synonyms": [
      "LGLL",
      "T gamma lymphoproliferative disorder",
      "T-LGL",
      "T-LGL leukaemia",
      "T-LGL leukemia",
      "T-cell LGL leukaemia",
      "T-cell LGL leukemia",
      "T-cell large gran. lymph. leuk.",
      "T-cell large granular lymphocyte leukemia",
      "T-cell large granular lymphocytic leukaemia",
      "T-cell large granular lymphocytic leukemia",
      "T-gamma lymphoproliferative disorder",
      "Tgamma large granular lymphocyte leukaemia",
      "Tgamma large granular lymphocyte leukemia",
      "large cell granular lymphogenous leukaemia",
      "large cell granular lymphogenous leukemia",
      "large cell granular lymphoid leukaemia",
      "large cell granular lymphoid leukemia",
      "large granular lymphocytic leukemia",
      "large granular lymphocytosis",
      "leukemia, large granular LYMPHOCYTIC, malignant",
      "proliferation of large granular lymphocytes",
      "LGL leukaemia",
      "LGL leukemia",
      "TLGL",
      "large granular lymphocyte leukaemia",
      "large granular lymphocyte leukemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "T-cell large granular lymphocyte leukemia (T-cell LGL leukemia) is a lymphoproliferative malignancy that arises from the mature T-cell (CD3+) lineage."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6891,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050743",
          "DOID:0050749",
          "GARD:0007368",
          "ICD10CM:C84.4",
          "ICDO:9702/3",
          "MEDGEN:1790498",
          "MESH:D016411",
          "NCIT:C3468",
          "SCTID:109977009",
          "UMLS:C5551485"
        ],
        "synonyms": [
          "PTCL",
          "mature T-and NK-cell lymphoma",
          "mature T-cell and NK-cell lymphoma",
          "mature T-cell and NK-cell non-Hodgkin lymphoma",
          "mature T-cell and NK-cell non-Hodgkin's lymphoma",
          "mature T-cell lymphoma",
          "mature T-cell non-Hodgkin's lymphoma",
          "peripheral T-cell lymphoma",
          "NK-T cell lymphoma",
          "mature T-cell and natural killer cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature T- and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000430"
    },
    {
      "id": 3274,
      "label": "chronic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1036",
          "ICD9:208.10",
          "MEDGEN:220905",
          "NCIT:C3483",
          "SCTID:92812005",
          "UMLS:C1279296"
        ],
        "synonyms": [
          "chronic leukaemia (disease)",
          "chronic leukemia",
          "chronic leukemia (disease)",
          "leukaemia (disease), chronic",
          "leukemia (disease), chronic",
          "adult chronic leukaemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia."
      },
      "child_count": 8,
      "reference_id": "MONDO:0001014"
    },
    {
      "id": 6778,
      "label": "immune system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2914",
          "EFO:0000540",
          "ICD9:279",
          "ICD9:279.1",
          "ICD9:279.10",
          "ICD9:279.19",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:279.8",
          "ICD9:279.9",
          "MEDGEN:5759",
          "MESH:D007154",
          "NANDO:1100004",
          "NANDO:2100202",
          "NCIT:C3507",
          "SCTID:414029004",
          "UMLS:C0021053"
        ],
        "synonyms": [
          "disease of immune system",
          "disease or disorder of immune system",
          "disorder of immune system",
          "immune disease",
          "immune disorder",
          "immune dysfunction",
          "immune system disease or disorder",
          "immune system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from an abnormality in the immune system."
      },
      "child_count": 47,
      "reference_id": "MONDO:0005046"
    },
    {
      "id": 7079,
      "label": "lymphoid leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789,
        6881
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1037",
          "DOID:10747",
          "EFO:0004289",
          "GARD:0024179",
          "HP:0005526",
          "ICD10CM:C91",
          "ICD9:204",
          "ICD9:204.2",
          "ICD9:204.20",
          "ICDO:981-983",
          "ICDO:9820/3",
          "MEDGEN:9728",
          "MESH:D007945",
          "NCIT:C7539",
          "SCTID:188726003",
          "UMLS:C0023448"
        ],
        "synonyms": [
          "leukemia, LYMPHOCYTIC, malignant",
          "lymphocytic leukemia",
          "lymphogenous leukaemia",
          "lymphogenous leukemia",
          "lymphoid leukaemia (disease)",
          "lymphoid leukemia",
          "lymphoid leukemia (disease)",
          "subacute lymphoid leukaemia",
          "subacute lymphoid leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005402"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma"
    },
    {
      "id": 3274,
      "label": "chronic leukemia"
    },
    {
      "id": 6778,
      "label": "immune system disorder"
    },
    {
      "id": 7079,
      "label": "lymphoid leukemia"
    }
  ]
}