{
  "id": 19295,
  "label": "aggressive NK-cell leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019470",
  "properties": {
    "xrefs": [
      "DOID:1035",
      "GARD:0010493",
      "ICDO:9948/3",
      "MEDGEN:266235",
      "MedDRA:10028811",
      "NANDO:2200012",
      "NCIT:C8647",
      "ONCOTREE:ANKL",
      "Orphanet:86873",
      "SCTID:721310007",
      "UMLS:C1292777",
      "icd11.foundation:153957345"
    ],
    "synonyms": [
      "ANKCL",
      "NK cell leukaemia",
      "NK cell leukemia",
      "NK-cell LGL leukaemia",
      "NK-cell LGL leukemia",
      "NK-cell large granular lymphocyte leukaemia",
      "NK-cell large granular lymphocyte leukemia",
      "NK-cell leukaemia",
      "NK-cell leukemia",
      "aggressive NK-cell leukaemia (morphologic abnormality)",
      "aggressive NK-cell leukemia",
      "aggressive NK-cell leukemia (morphologic abnormality)",
      "aggressive NK-cell leukemia/lymphoma",
      "aggressive NK-cell lymphoma",
      "leukaemia (disease) of natural killer cell",
      "leukemia (disease) of natural killer cell",
      "natural Killer cell leukemia",
      "natural killer cell leukaemia (disease)",
      "natural killer cell leukemia",
      "natural killer cell leukemia (disease)",
      "ANKL",
      "aggressive NK cell leukaemia",
      "aggressive NK cell leukemia",
      "aggressive natural killer cell leukaemia",
      "aggressive natural killer cell leukemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6891,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050743",
          "DOID:0050749",
          "GARD:0007368",
          "ICD10CM:C84.4",
          "ICDO:9702/3",
          "MEDGEN:1790498",
          "MESH:D016411",
          "NCIT:C3468",
          "SCTID:109977009",
          "UMLS:C5551485"
        ],
        "synonyms": [
          "PTCL",
          "mature T-and NK-cell lymphoma",
          "mature T-cell and NK-cell lymphoma",
          "mature T-cell and NK-cell non-Hodgkin lymphoma",
          "mature T-cell and NK-cell non-Hodgkin's lymphoma",
          "mature T-cell lymphoma",
          "mature T-cell non-Hodgkin's lymphoma",
          "peripheral T-cell lymphoma",
          "NK-T cell lymphoma",
          "mature T-cell and natural killer cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature T- and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000430"
    },
    {
      "id": 3274,
      "label": "chronic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1036",
          "ICD9:208.10",
          "MEDGEN:220905",
          "NCIT:C3483",
          "SCTID:92812005",
          "UMLS:C1279296"
        ],
        "synonyms": [
          "chronic leukaemia (disease)",
          "chronic leukemia",
          "chronic leukemia (disease)",
          "leukaemia (disease), chronic",
          "leukemia (disease), chronic",
          "adult chronic leukaemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia."
      },
      "child_count": 8,
      "reference_id": "MONDO:0001014"
    },
    {
      "id": 5443,
      "label": "T lymphoblastic leukemia/lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5444,
        21530
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5599",
          "GARD:0023552",
          "ICDO:9837/3",
          "MEDGEN:224897",
          "NCIT:C8694",
          "UMLS:C1301359"
        ],
        "synonyms": [
          "precursor T lymphoblastic leukemia/lymphoma",
          "precursor T lymphoblastic lymphoma/leukemia",
          "precursor T-lymphoblastic lymphoma/leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called T acute lymphoblastic leukemia. When it involves nodal or extranodal sites it is called T lymphoblastic lymphoma. (WHO, 2001)"
      },
      "child_count": 10,
      "reference_id": "MONDO:0003537"
    },
    {
      "id": 6706,
      "label": "T-cell acute lymphoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6710,
        7179
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2004-1600",
          "CSP:2004-1803",
          "DOID:5603",
          "EFO:0000209",
          "GARD:0024138",
          "HGNC:5056",
          "ICDO:9837/3",
          "MEDGEN:368378",
          "NANDO:2200003",
          "NCIT:C3183",
          "SCTID:277575008",
          "UMLS:C1961099"
        ],
        "synonyms": [
          "acute T cell leukaemia",
          "T acute lymphoblastic leukaemia",
          "T acute lymphoblastic leukemia",
          "T-ALL",
          "T-cell ALL",
          "T-cell acute lymphoblastic leukaemia",
          "T-cell acute lymphoblastic leukemia",
          "T-cell acute lymphocytic leukemia",
          "T-cell type acute leukaemia",
          "T-cell type acute leukemia",
          "acute T cell leukemia",
          "acute T cell lymphoblastic leukaemia",
          "acute T cell lymphoblastic leukemia",
          "acute T cell lymphocytic leukaemia",
          "acute T cell lymphocytic leukemia",
          "acute T-cell leukaemia",
          "acute T-cell leukemia",
          "acute T-cell lymphoblastic leukaemia",
          "acute T-cell lymphoblastic leukemia",
          "acute T-cell lymphocytic leukaemia",
          "acute T-cell lymphocytic leukemia",
          "precursor T lymphoblastic leukaemia",
          "precursor T-lymphoblastic leukaemia",
          "precursor T-lymphoblastic leukaemia (T-cell ALL)",
          "precursor T-lymphoblastic leukemia",
          "precursor T-lymphoblastic leukemia (T-cell ALL)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females. (WHO, 2001)"
      },
      "child_count": 8,
      "reference_id": "MONDO:0004963"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma"
    },
    {
      "id": 3274,
      "label": "chronic leukemia"
    },
    {
      "id": 5443,
      "label": "T lymphoblastic leukemia/lymphoma"
    },
    {
      "id": 6706,
      "label": "T-cell acute lymphoblastic leukemia"
    }
  ]
}