{
  "id": 19297,
  "label": "extranodal nasal NK/T cell lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019472",
  "properties": {
    "xrefs": [
      "DOID:0080797",
      "GARD:0007041",
      "ICD10CM:C86.0",
      "ICDO:9719/3",
      "MEDGEN:140278",
      "MedDRA:10065855",
      "NANDO:2200027",
      "NCIT:C4684",
      "Orphanet:86879",
      "UMLS:C0392788",
      "icd11.foundation:684005900"
    ],
    "synonyms": [
      "Extranodal NK/T lymphoma-nasal",
      "Extranodal NK/T-cell lymphoma, nasal type",
      "NK/T-cell lymphoma",
      "NKTCL",
      "angiocentric T-cell lymphoma",
      "lethal midline granuloma",
      "nasal T/natural killer-cell lymphoma",
      "nasal type Extranodal NK/T-cell lymphoma",
      "reticulosis, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare, malignant neoplasm mainly affecting men in the fifth decade of life, that usually arises in the nose, paranasal sinuses, orbits or upper airway, and that can present with a nasal mass, nasal bleeding, nasal obstruction, palate perforation (i.e. midline perforation of the hard palate), and mid-facial and/or upper airway destructive lesions. In advanced disease stages, which are associated with a poor prognosis, NKTCL may disseminate to other organs. A few cases of NKTCL presenting primarily in the lymph nodes have also been described."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6792,
      "label": "lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6881,
        16514
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060058",
          "EFO:0000574",
          "ICD9:200.0",
          "ICD9:200.1",
          "ICD9:202.80",
          "ICDO:9590/3",
          "MEDGEN:44223",
          "MESH:D008223",
          "MedDRA:10025310",
          "NANDO:2100004",
          "NCIT:C3208",
          "ONCOTREE:MLYM",
          "Orphanet:223735",
          "SCTID:118600007",
          "UMLS:C0024299"
        ],
        "synonyms": [
          "lymphoma",
          "lymphoma (Hodgkin and non-Hodgkin)",
          "lymphoma (Hodgkin's and non-Hodgkin's)",
          "lymphoma, malignant",
          "lymphomatous",
          "malignant lymphoma",
          "MLYM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas."
      },
      "child_count": 54,
      "reference_id": "MONDO:0005062"
    },
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021147",
          "MEDGEN:797800",
          "MedDRA:10068349",
          "Orphanet:289644",
          "UMLS:C2363744"
        ],
        "synonyms": [
          "EBV-associated lymphoproliferative disorder",
          "Epstein-Barr virus-associated malignant lymphoproliferative disorder"
        ],
        "definition": "A range of lymphoproliferative diseases characterized by uncontrolled proliferation of B cells, T cells, or NK cells infected with Epstein-Barr virus. Depending on host immunity and viral factors, viral persistence in host cells can induce lymphoproliferation with a diverse clinical spectrum ranging from simple reactive hyperplasia to aggressive lymphoma/leukemia with unique clinical and pathological presentations."
      },
      "child_count": 11,
      "reference_id": "MONDO:0017343"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6792,
      "label": "lymphoma"
    },
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder"
    }
  ]
}