{
  "id": 19305,
  "label": "methotrexate-associated lymphoproliferative disorders",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019483",
  "properties": {
    "xrefs": [
      "DOID:5821",
      "GARD:0019083",
      "MEDGEN:233702",
      "NCIT:C7184",
      "Orphanet:86904",
      "UMLS:C1334749",
      "icd11.foundation:1520483526"
    ],
    "synonyms": [
      "MTX-LPD",
      "MTX-associated lymphoproliferative disorders",
      "methotrexate-associated lymphoproliferation",
      "methotrexate-associated lymphoproliferative disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Methotrexate-associated lymphoproliferative disorders are rare immunodeficiency-associated lymphoproliferative diseases characterized by lymphoid proliferation or lymphomas (large B-cell lymphoma, T-cell lymphoma, Hodgkin lymphoma, reactive lymphadenitis and a polymorphic post-transplant lymphoproliferative disorder) that develop in patients with different autoimmune diseases treated with methotrexate. Swelling is the predominant manifestation of the disease and regression after methotrexate withdrawal is observed in a significant proportion of patients."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6792,
      "label": "lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6881,
        16514
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060058",
          "EFO:0000574",
          "ICD9:200.0",
          "ICD9:200.1",
          "ICD9:202.80",
          "ICDO:9590/3",
          "MEDGEN:44223",
          "MESH:D008223",
          "MedDRA:10025310",
          "NANDO:2100004",
          "NCIT:C3208",
          "ONCOTREE:MLYM",
          "Orphanet:223735",
          "SCTID:118600007",
          "UMLS:C0024299"
        ],
        "synonyms": [
          "lymphoma",
          "lymphoma (Hodgkin and non-Hodgkin)",
          "lymphoma (Hodgkin's and non-Hodgkin's)",
          "lymphoma, malignant",
          "lymphomatous",
          "malignant lymphoma",
          "MLYM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas."
      },
      "child_count": 54,
      "reference_id": "MONDO:0005062"
    },
    {
      "id": 19730,
      "label": "immunodeficiency-associated lymphoproliferative disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16514
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019443",
          "MEDGEN:1843142",
          "NCIT:C150672",
          "Orphanet:98290",
          "UMLS:C5681530",
          "icd11.foundation:1678636940"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0020083"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6792,
      "label": "lymphoma"
    },
    {
      "id": 19730,
      "label": "immunodeficiency-associated lymphoproliferative disease"
    }
  ]
}