{
  "id": 19343,
  "label": "paroxysmal cold hemoglobinuria",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019533",
  "properties": {
    "xrefs": [
      "GARD:0007335",
      "MEDGEN:39693",
      "NANDO:1200308",
      "NANDO:2200619",
      "NORD:1556",
      "Orphanet:90035",
      "SCTID:127057004",
      "UMLS:C0086774",
      "icd11.foundation:715111132"
    ],
    "synonyms": [
      "Donath-Landsteiner hemolytic anaemia",
      "Donath-Landsteiner hemolytic anemia",
      "Donath-Landsteiner syndrome",
      "PCH",
      "hemoglobinuria paroxysmal cold"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Paroxysmal cold hemoglobinuria (PCH) is a very rare subtype of autoimmune hemolytic anemia (AIHA), caused by the presence of cold-reacting autoantibodies in the blood and characterized by the sudden presence of hemoglobinuria, typically after exposure to cold temperatures."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16961,
      "label": "autoimmune hemolytic anemia, cold type",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020590",
          "MEDGEN:104501",
          "Orphanet:228312",
          "UMLS:C0175816",
          "icd11.foundation:1836938544"
        ],
        "synonyms": [
          "cAHA",
          "cAIHA",
          "cold AIHA"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Cold autoimmune hemolytic anemia comprises two types of autoimmune hemolytic anemia (AIHA) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30B0C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold hemoglobinuria (PCH)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016450"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16961,
      "label": "autoimmune hemolytic anemia, cold type"
    }
  ]
}