{
  "id": 19350,
  "label": "acute liver failure",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019542",
  "properties": {
    "xrefs": [
      "GARD:0019112",
      "MEDGEN:58125",
      "MESH:D017114",
      "MedDRA:10000804",
      "NCIT:C84396",
      "Orphanet:90062",
      "SCTID:197270009",
      "UMLS:C0162557"
    ],
    "synonyms": [
      "acute hepatic failure",
      "fulminant hepatic failure"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Rapid deterioration of liver function causing encephalopathy and coagulopathy. It results from damage to the liver parenchyma usually secondary to acetaminophen overdose or viral infections."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 20092,
      "label": "acute disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24492
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:799.89",
          "MEDGEN:1738",
          "MESH:D000208",
          "SCTID:2704003",
          "UMLS:C0001314"
        ],
        "synonyms": [
          "acute disease",
          "acute diseases",
          "disease, acute"
        ],
        "definition": "Disease having a short and relatively severe course."
      },
      "child_count": 119,
      "reference_id": "MONDO:0020683"
    },
    {
      "id": 23933,
      "label": "liver failure",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6878
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:88444",
          "MESH:D017093",
          "NCIT:C26922",
          "UMLS:C0085605"
        ],
        "synonyms": [
          "hepatic failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A liver disease characterized by the liver losing or has lost all of its function."
      },
      "child_count": 3,
      "reference_id": "MONDO:0100192"
    }
  ],
  "children": [
    {
      "id": 14149,
      "label": "acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2706,
        16918,
        19350
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080778",
          "GARD:0010593",
          "MEDGEN:480294",
          "OMIM:613070",
          "Orphanet:217371",
          "UMLS:C3278664"
        ],
        "synonyms": [
          "acute infantile liver failure",
          "LFIT",
          "TRMU infantile liver failure",
          "acute infantile liver failure due to synthesis defect of mitochondrial DNA-encoded proteins",
          "acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins",
          "infantile liver failure caused by mutation in TRMU",
          "liver failure, infantile, transient",
          "liver failure, transient infantile",
          "transient infantile liver failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Acute infantile liver failure due to mtDNA-encoded proteins synthesis defect is a very rare mitochondrial respiratory chain deficiency described in fewer than 10 infants, primarily of middle Eastern descent, and characterized clinically by transient but life-threatening liver failure with elevated liver enzymes, jaundice, vomiting, coagulopathy, hyperbilirubinemia, and lactic acidemia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013111"
    }
  ],
  "roots": [
    {
      "id": 20092,
      "label": "acute disease"
    },
    {
      "id": 23933,
      "label": "liver failure"
    }
  ]
}