{
  "id": 19364,
  "label": "chilblain lupus",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019557",
  "properties": {
    "xrefs": [
      "DOID:0060386",
      "GARD:0019130",
      "MEDGEN:1632142",
      "MedDRA:10025141",
      "Orphanet:90280",
      "UMLS:C4551515"
    ],
    "synonyms": [
      "CHLE",
      "Hutchinson lupus"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A rare, chronic cutaneous lupus erythematosus disease characterized by red or violaceous, initially pruritic (evolving to painful) papules and plaques located on acral areas (especially dorsal aspects of fingers and toes, while the nose and ear involvement is uncommon), exacerbated by cold and damp conditions, with fissuring and ulceration occasionally observed. Coexistence of discoid lupus erythematosus lesions elsewhere on the body and occasional progression to systemic lupus erythematosus may be associated. Histological examination and direct immunofluorescence studies reveal nonspecific inflammatory lupus erythematosus changes while results of cryoglobulin and cold agglutinin studies are negative."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 3017,
      "label": "autoimmune disorder of cardiovascular system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060051"
        ],
        "synonyms": [
          "cardiovascular system autoimmune disease",
          "cardiovascular system hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the cardiovascular system."
      },
      "child_count": 12,
      "reference_id": "MONDO:0000603"
    },
    {
      "id": 16381,
      "label": "chronic cutaneous lupus erythematosus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6978
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020043",
          "MedDRA:10057929",
          "Orphanet:163531",
          "icd11.foundation:1849568465"
        ],
        "synonyms": [
          "cutaneous lupus erythematosus, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Chronic cutaneous lupus erythematosus (CCLE) is a form of cutaneous lupus erythematosus (CLE) that includes five different forms: discoid lupus erythematosus (DLE), chilblain lupus, hypertrophic or verrucous lupus erythematosus, lupus erythematosus tumidus, and lupus erythematosus panniculitis."
      },
      "child_count": 5,
      "reference_id": "MONDO:0015574"
    },
    {
      "id": 19142,
      "label": "skin vascular disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9540",
          "ICD9:709.1",
          "MEDGEN:102473",
          "MESH:D017445",
          "MedDRA:10062171",
          "NCIT:C35254",
          "Orphanet:79379",
          "SCTID:11263005",
          "UMLS:C0162819"
        ],
        "synonyms": [
          "skin vascular disorder",
          "superficial vasculature disease",
          "vascular disease of the skin",
          "vascular skin disease",
          "vasculature skin disease",
          "disorder of blood vessels affecting skin",
          "vascular disorder of skin",
          "vascular disorders of skin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease that involves the superficial vasculature."
      },
      "child_count": 40,
      "reference_id": "MONDO:0019293"
    }
  ],
  "children": [
    {
      "id": 18767,
      "label": "familial chilblain lupus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19364,
        21247,
        23867,
        25666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017874",
          "MEDGEN:1807766",
          "OMIMPS:610448",
          "Orphanet:481662",
          "UMLS:C5688224"
        ],
        "synonyms": [
          "hereditary Chilblain lupus",
          "hereditary chilblain lupus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An instance of Chilblain lupus that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018827"
    }
  ],
  "roots": [
    {
      "id": 3017,
      "label": "autoimmune disorder of cardiovascular system"
    },
    {
      "id": 16381,
      "label": "chronic cutaneous lupus erythematosus"
    },
    {
      "id": 19142,
      "label": "skin vascular disease"
    }
  ]
}