{
  "id": 19404,
  "label": "functioning gonadotropic adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019612",
  "properties": {
    "xrefs": [
      "GARD:0019158",
      "MEDGEN:577353",
      "NCIT:C45915",
      "Orphanet:91348",
      "SCTID:254960002",
      "UMLS:C0346304"
    ],
    "synonyms": [
      "functioning pituitary gonadotropic adenoma",
      "gonadotroph adenoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Functioning gonadotropic adenoma is a very rare pituitary tumor, macroscopically characterized by a soft, well vascularized, variable sized adenoma, with occasional areas of hemorrage or necrosis, that secretes biologically active gonadotropins. In addition to common neurological signs due to mass effect (headache and/or visual field deterioration), additional clinical manifestations include menstrual irregularities (secondary amenorrhea, oligomenorhea or severe menorrhagia), galactorrhea, infertility or ovarian hyperstimulation syndrome (in premenopausal women), testicular enlargement and, occasionally, hypogonadism (in men) and isosexual precocious puberty (in children)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5357,
      "label": "functioning pituitary gland adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5498,
        7896
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5395",
          "GARD:0021389",
          "MEDGEN:163135",
          "NCIT:C8388",
          "Orphanet:314753",
          "UMLS:C0854486"
        ],
        "synonyms": [
          "endocrine active pituitary adenoma",
          "functioning adenoma of pituitary",
          "functioning adenoma of pituitary gland",
          "functioning adenoma of the pituitary",
          "functioning adenoma of the pituitary gland",
          "functioning pituitary adenoma",
          "functioning pituitary gland adenoma",
          "functioning pituitary gland adenoma (benign)",
          "secreting pituitary adenoma",
          "secretory adenoma of pituitary",
          "secretory adenoma of pituitary gland",
          "secretory adenoma of the pituitary",
          "secretory adenoma of the pituitary gland",
          "secretory pituitary adenoma",
          "secretory pituitary gland adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormone producing pituitary gland adenoma, associated with a hormonal syndrome."
      },
      "child_count": 10,
      "reference_id": "MONDO:0003429"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5357,
      "label": "functioning pituitary gland adenoma"
    }
  ]
}