{
  "id": 19481,
  "label": "congenital anomaly of kidney and urinary tract",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019719",
  "properties": {
    "xrefs": [
      "DOID:0080205",
      "GARD:0019216",
      "MEDGEN:369894",
      "MESH:C566906",
      "OMIMPS:610805",
      "Orphanet:93545",
      "UMLS:C1968949"
    ],
    "synonyms": [
      "CAKUT",
      "congenital anomalies of kidney and urinary tract",
      "congenital anomaly of kidney and urinary tract",
      "renal or urinary tract malformation"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A urinary system disease characterized by structural malformations in the kidney and/or urinary tract containing vesicoureteral reflux."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 19507,
      "label": "developmental defect during embryogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:759.7",
          "MEDGEN:1825997",
          "NCIT:C99267",
          "Orphanet:93890",
          "SCTID:400038003",
          "UMLS:C5680284"
        ],
        "synonyms": [
          "congenital malformation syndrome",
          "developmental defect during embryogenesis",
          "disorder of embryonic morphogenesis",
          "embryonic morphogenesis disease",
          "malformation syndrome",
          "rare developmental defect during embryogenesis"
        ],
        "definition": "A disease that has its basis in the disruption of embryonic morphogenesis."
      },
      "child_count": 52,
      "reference_id": "MONDO:0019755"
    },
    {
      "id": 23932,
      "label": "inherited kidney disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6948
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "genetic renal disease",
          "inherited kidney disease",
          "inherited renal disorder",
          "nephrogenetic disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions, with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology that are characterized by abnormalities in the kidney or urinary system."
      },
      "child_count": 52,
      "reference_id": "MONDO:0100191"
    }
  ],
  "children": [
    {
      "id": 13608,
      "label": "congenital anomalies of kidney and urinary tract 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080206",
          "GARD:0024873",
          "MEDGEN:322763",
          "MESH:C563661",
          "OMIM:610805",
          "UMLS:C1835826"
        ],
        "synonyms": [
          "CAKUT1",
          "DSTYK congenital anomaly of kidney and urinary tract",
          "congenital anomalies of kidney and urinary tract 1",
          "congenital anomaly of kidney and urinary tract caused by mutation in DSTYK",
          "renal hypodysplasia, nonsyndromic, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Any congenital anomaly of kidney and urinary tract in which the cause of the disease is a mutation in the DSTYK gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012561"
    },
    {
      "id": 21763,
      "label": "congenital anomalies of kidney and urinary tract 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080207",
          "GARD:0025500",
          "MEDGEN:1804316",
          "OMIM:143400",
          "UMLS:C5574705"
        ],
        "synonyms": [
          "TBX18 congenital anomaly of kidney and urinary tract",
          "congenital anomalies of kidney and urinary tract 2",
          "congenital anomalies of kidney and urinary tract type 2",
          "congenital anomaly of kidney and urinary tract caused by mutation in TBX18",
          "CAKUT2",
          "hydronephrosis due to Pujo",
          "multicystic renal dysplasia, bilateral",
          "pelviureteric junction obstruction",
          "ureteropelvic junction obstruction"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Any congenital anomaly of kidney and urinary tract in which the cause of the disease is a mutation in the TBX18 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0027676"
    },
    {
      "id": 22328,
      "label": "congenital anomalies of kidney and urinary tract 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025711",
          "MEDGEN:1648427",
          "OMIM:618270",
          "UMLS:C4748921"
        ],
        "synonyms": [
          "CAKUT3",
          "CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0032646"
    }
  ],
  "roots": [
    {
      "id": 19507,
      "label": "developmental defect during embryogenesis"
    },
    {
      "id": 23932,
      "label": "inherited kidney disorder"
    }
  ]
}