{
  "id": 19482,
  "label": "glomerular disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019722",
  "properties": {
    "xrefs": [
      "EFO:1002049",
      "GTR:AN0966176",
      "ICD10CM:N00-N08",
      "MEDGEN:451033",
      "NCIT:C120887",
      "Orphanet:93548",
      "SCTID:197679002",
      "UMLS:C0268731"
    ],
    "synonyms": [
      "disease of renal glomerulus",
      "disease or disorder of renal glomerulus",
      "disorder of renal glomerulus",
      "glomerulopathy",
      "renal glomerulus disease",
      "renal glomerulus disease or disorder",
      "glomerulopathies"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A disease involving the renal glomerulus."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 6948,
      "label": "kidney disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4253
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:557",
          "EFO:0003086",
          "ICD9:583.81",
          "MEDGEN:9635",
          "MESH:D007674",
          "NCIT:C3149",
          "SCTID:90708001",
          "UMLS:C0022658"
        ],
        "synonyms": [
          "disease of kidney",
          "disease or disorder of kidney",
          "disorder of kidney",
          "kidney disease",
          "kidney disease or disorder",
          "kidney disorder",
          "renal disease",
          "renal disorder",
          "nephropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A disease involving the kidney."
      },
      "child_count": 57,
      "reference_id": "MONDO:0005240"
    }
  ],
  "children": [
    {
      "id": 2948,
      "label": "glomerulosclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19482
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050851",
          "GARD:0022776",
          "MEDGEN:61248",
          "NCIT:C120888",
          "SCTID:197661001",
          "UMLS:C0178664",
          "icd11.foundation:2068645853"
        ],
        "synonyms": [
          "glomerular sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A hardening of the kidney glomerulus caused by scarring of the blood vessels."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000490"
    },
    {
      "id": 4542,
      "label": "glomerulonephritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3410,
        19482
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2921",
          "GARD:0006516",
          "HP:0000099",
          "ICD9:583.9",
          "MEDGEN:6616",
          "MESH:D005921",
          "NCIT:C26784",
          "SCTID:36171008",
          "UMLS:C0017658"
        ],
        "synonyms": [
          "glomerular nephritis",
          "glomerulonephritis",
          "glomerulonephritis (disease)",
          "nephritis of renal glomerulus",
          "renal glomerulus nephritis",
          "bright's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A renal disorder characterized by damage in the glomeruli. It may be acute or chronic, focal or diffuse, and it may lead to renal failure. Causes include autoimmune disorders, infections, diabetes, and malignancies."
      },
      "child_count": 40,
      "reference_id": "MONDO:0002462"
    },
    {
      "id": 9029,
      "label": "fibronectin glomerulopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19482,
        23932
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015019",
          "MEDGEN:854773",
          "MESH:C536826",
          "MESH:C562900",
          "NANDO:2200133",
          "OMIMPS:137950",
          "Orphanet:84090",
          "SCTID:236535001",
          "UMLS:C3888104",
          "icd11.foundation:1877494378"
        ],
        "synonyms": [
          "GFND",
          "fibronectin glomerulopathy",
          "glomerulopathy with fibronectin deposits",
          "GFND1",
          "GFND2",
          "glomerular nephritis, familial, with fibronectin deposits",
          "glomerulopathy with fibronectin deposits 1",
          "glomerulopathy with fibronectin deposits 2",
          "glomerulopathy with giant fibrillar deposits",
          "lobular glomerulopathy, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A hereditary kidney disease characterized by proteinuria, type IV renal tubular acidosis, microscopic hematuria and hypertension that may lead to end-stage renal failure in the second to sixth decade of life."
      },
      "child_count": 4,
      "reference_id": "MONDO:0007671"
    },
    {
      "id": 18962,
      "label": "congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19482
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018896",
          "MEDGEN:1384031",
          "Orphanet:69063",
          "SCTID:725592009",
          "UMLS:C4511239"
        ],
        "synonyms": [
          "FMAIG",
          "alloimmune neonatal renal disease",
          "fetomaternal alloimmunization with antenatal glomerulopathies",
          "neonatal glomerulopathy due to Neprilysin alloimmunization",
          "neonatal glomerulopathy due to neprilysin alloimmunization",
          "neonatal membranous glomerulopathy with maternal NEP deficiency",
          "neonatal membranous glomerulopathy with maternal neutral endopeptidase deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A glomerular disease characterized by severe renal failure and nephrotic syndrome at birth, which rapidly improve in the first weeks of life."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019068"
    },
    {
      "id": 19226,
      "label": "collagen type III glomerulopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19482
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019048",
          "ICD9:583.89",
          "MEDGEN:836996",
          "Orphanet:84087",
          "SCTID:708127008",
          "UMLS:C3872695"
        ],
        "synonyms": [
          "Collagenofibrotic glomerulopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare glomerular disease characterized by abnormal accumulation of type III collagen within the mesangium and subendothelial space of the glomerulus. Clinically it usually manifests with proteinuria (often in the nephrotic range), microscopic hematuria, peripheral edema and/or hypertension. In some cases progression to end-stage renal failure is observed."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019396"
    },
    {
      "id": 19398,
      "label": "immunotactoid or fibrillary glomerulopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19482
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012741",
          "MEDGEN:1842578",
          "Orphanet:91137",
          "UMLS:C5680195"
        ],
        "synonyms": [
          "Immunotactoid or fibrillary glomerulonephritis",
          "fibrillary glomerulonephritis and immunotactoid glomerulopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A group of very rare glomerular diseases, composed of immunotactoid glomerulopathy (ITG) and non-amyloid fibrillary glomerulopathy (non-amyloid FGP), that are characterized by mesangial deposition of monoclonal microtubular or polyclonal fibrillar deposits. Both present clinically with nephrotic range proteinuria, hematuria and renal insufficiency leading to renal failure in many cases. ITG is more likely to manifest with underlying lymphoproliferative disease, hypocomplementemia, dysproteinemia, monoclonal gammopathy or occult cryoglobulinemia. Non-amyloid FGP is 10 times more frequent than ITG."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019605"
    }
  ],
  "roots": [
    {
      "id": 6948,
      "label": "kidney disorder"
    }
  ]
}