{
  "id": 19494,
  "label": "dense deposit disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019736",
  "properties": {
    "xrefs": [
      "GARD:0008555",
      "MEDGEN:124345",
      "NANDO:1200739",
      "NCIT:C123039",
      "Orphanet:93571",
      "SCTID:722760002",
      "UMLS:C0268743"
    ],
    "synonyms": [
      "Mesangiocapillary glomerulonephritis type 2",
      "membranoproliferative glomerulonephritis type 2",
      "MPGN 2",
      "glomerulonephritis membranoproliferative type 2",
      "membranoproliferative glomerulonephritis type II"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A histological subtype of C3 glomerulopathy characterized by C3 deposition in renal tissue in the absence or near-absence of immunoglobulin deposits, in a patient with the classic clinical features of glomerulonephritis and electron microscopic findings of highly electron-dense intra-membranous, osmiophilic deposits."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18187,
      "label": "complement 3 glomerulopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017507",
          "MEDGEN:1672497",
          "Orphanet:329918",
          "UMLS:C4087273"
        ],
        "synonyms": [
          "C3 glomerulopathy",
          "C3G",
          "non-Ig-mediated MPGN",
          "non-Ig-mediated membranoproliferative glomerulonephritis",
          "non-immunoglobulin-mediated MPGN",
          "non-immunoglobulin-mediated membranoproliferative glomerulonephritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare primary membranoproliferative glomerulonephritis characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples."
      },
      "child_count": 3,
      "reference_id": "MONDO:0018013"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18187,
      "label": "complement 3 glomerulopathy"
    }
  ]
}