{
  "id": 19506,
  "label": "multicentric Castleman disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019754",
  "properties": {
    "xrefs": [
      "DOID:0111152",
      "GARD:0022310",
      "MEDGEN:233197",
      "NCIT:C27855",
      "Orphanet:570438",
      "Orphanet:93686",
      "UMLS:C1334815",
      "icd11.foundation:1590444463"
    ],
    "synonyms": [
      "HHV-8-associated multicentric Castleman disease",
      "Human herpesvirus-8-associated multicentric Castleman disease",
      "MCD",
      "multicentric Angiofollicular lymphoid hyperplasia",
      "multicentric Castleman's disease",
      "idiopathic multicentric Castleman's disease",
      "multicentric plasma cell variant of Castleman's disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Multicentric castleman disease (MCD) is an aggressive form of Castleman disease that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16085,
      "label": "human herpesvirus 8-related tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17658
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019830",
          "MEDGEN:1843228",
          "NCIT:C27697",
          "Orphanet:102024",
          "UMLS:C5680371"
        ],
        "synonyms": [
          "HHV-8-related disorder"
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0015157"
    },
    {
      "id": 16372,
      "label": "Castleman disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111157",
          "GARD:0012656",
          "ICD10CM:D47.Z2",
          "MEDGEN:42211",
          "MESH:D005871",
          "MedDRA:10050251",
          "NCIT:C3056",
          "NORD:898",
          "Orphanet:160",
          "SCTID:207036003",
          "UMLS:C0017531",
          "icd11.foundation:1940989685"
        ],
        "synonyms": [
          "AFLH",
          "Castleman disease",
          "Castleman's disease",
          "Castleman's tumor",
          "Castleman's tumour",
          "GLNH",
          "angiofollicular ganglionic hyperplasia",
          "angiofollicular lymph hyperplasia",
          "angiofollicular lymph node hyperplasia",
          "angiofollicular lymphoid hyperplasia",
          "giant lymph node hyperplasia",
          "ALNH"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form. The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015564"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16085,
      "label": "human herpesvirus 8-related tumor"
    },
    {
      "id": 16372,
      "label": "Castleman disease"
    }
  ]
}