{
  "id": 19525,
  "label": "astrocytoma (excluding glioblastoma)",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019781",
  "properties": {
    "xrefs": [
      "EFO:0000272",
      "GARD:0025146",
      "ICDO:9400/3",
      "MEDGEN:438",
      "MESH:D001254",
      "NCIT:C60781",
      "ONCOTREE:ASTR",
      "SCTID:147101000119108",
      "UMLS:C0004114"
    ],
    "synonyms": [
      "astrocytoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 20692,
      "label": "astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3069",
          "GARD:0012928",
          "MedDRA:10003571",
          "NCIT:C6958",
          "Orphanet:94"
        ],
        "synonyms": [
          "astrocytic neoplasm",
          "astrocytic tumor",
          "astrocytoma, no ICD-O subtype",
          "astroglioma",
          "astrocytoma",
          "astrocytoma of cerebrum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0021636"
    }
  ],
  "children": [
    {
      "id": 5129,
      "label": "cauda equina intradural extramedullary astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5130,
        19525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4846",
          "GARD:0023390",
          "MEDGEN:235225",
          "NCIT:C5408",
          "UMLS:C1334254"
        ],
        "synonyms": [
          "intradural extramedullary Cauda equina astrocytoma",
          "intradural extramedullary astrocytic tumour of the Cauda equina",
          "intradural extramedullary astrocytoma of Cauda equina",
          "intradural extramedullary astrocytoma of the Cauda equina"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0003163"
    },
    {
      "id": 5138,
      "label": "spinal cord astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4608,
        19525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4863",
          "EFO:1000544",
          "GARD:0023397",
          "MEDGEN:91152",
          "NCIT:C4641",
          "SCTID:254948003",
          "UMLS:C0349540"
        ],
        "synonyms": [
          "astrocytoma (excluding glioblastoma) of spinal cord",
          "astrocytoma of spinal cord",
          "astrocytoma of the spinal cord",
          "spinal astrocytoma",
          "spinal cord astrocytoma",
          "spinal cord astrocytoma (excluding glioblastoma)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A low or high grade astrocytoma that arises in the spinal cord."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003174"
    },
    {
      "id": 17148,
      "label": "anaplastic astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17144,
        19525,
        20048
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3078",
          "EFO:0002499",
          "GARD:0005860",
          "ICDO:9401/3",
          "MEDGEN:137784",
          "MedDRA:10002224",
          "MedDRA:10060971",
          "NANDO:2200086",
          "NCIT:C9477",
          "NORD:769",
          "ONCOTREE:AASTR",
          "Orphanet:251589",
          "UMLS:C0334579"
        ],
        "synonyms": [
          "anaplastic astrocytoma",
          "astrocytoma, anaplastic, malignant",
          "grade III astrocytic neoplasm",
          "grade III astrocytic tumor",
          "grade III astrocytic tumour",
          "grade III astrocytoma",
          "malignant astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0016684"
    },
    {
      "id": 17149,
      "label": "low-grade astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19525,
        20694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020706",
          "MEDGEN:727259",
          "MedDRA:10065869",
          "Orphanet:251592",
          "UMLS:C1314694"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 10,
      "reference_id": "MONDO:0016685"
    },
    {
      "id": 20687,
      "label": "brain astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19525,
        20688
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025341",
          "MEDGEN:811330",
          "NCIT:C60780",
          "SCTID:254938000",
          "UMLS:C3695127"
        ],
        "synonyms": [
          "astrocytoma (excluding glioblastoma) of brain",
          "brain astrocytoma",
          "brain astrocytoma (excluding glioblastoma)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A astrocytoma (excluding glioblastoma) that involves the brain."
      },
      "child_count": 8,
      "reference_id": "MONDO:0021631"
    }
  ],
  "roots": [
    {
      "id": 20692,
      "label": "astrocytic tumor"
    }
  ]
}