{
  "id": 19564,
  "label": "pituitary stalk interruption syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019828",
  "properties": {
    "xrefs": [
      "GARD:0013209",
      "MEDGEN:883774",
      "NCIT:C121150",
      "Orphanet:95496",
      "SCTID:715727009",
      "UMLS:C4053775",
      "icd11.foundation:1474283222"
    ],
    "synonyms": [
      "PSIS",
      "ectopic neurohypophysis",
      "hypoplastic anterior pituitary, missing stalk, and ectopic posterior pituitary"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Pituitary stalk interruption syndrome (PSIS) is a congenital abnormality of the pituitary that is responsible for pituitary deficiency and is usually characterized by the triad of a very thin or interrupted pituitary stalk, an ectopic (or absent) posterior pituitary (EPP) and hypoplasia or aplasia of the anterior pituitary visible on MRI. In some patients the abnormality may be limited to EPP (also called ectopic neurohypophysis) or to an interrupted pituitary stalk."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 19562,
      "label": "non-acquired pituitary hormone deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16072,
        16330
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019272",
          "MEDGEN:1842784",
          "Orphanet:95488",
          "UMLS:C5681572"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 10,
      "reference_id": "MONDO:0019824"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 19562,
      "label": "non-acquired pituitary hormone deficiency"
    }
  ]
}