{
  "id": 19567,
  "label": "acquired pituitary hormone deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019832",
  "properties": {
    "xrefs": [
      "GARD:0019278",
      "MEDGEN:1843262",
      "NANDO:2200313",
      "Orphanet:95502",
      "UMLS:C5681569"
    ],
    "synonyms": [
      "acquired hypopituitarism"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An instance of hypopituitarism that is acquired during the lifetime of the individual."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6876,
      "label": "hypopituitarism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9406",
          "EFO:0001380",
          "ICD10CM:E23.0",
          "MEDGEN:9386",
          "MESH:D007018",
          "NANDO:1200387",
          "NANDO:2100110",
          "NCIT:C62591",
          "SCTID:74728003",
          "UMLS:C0020635",
          "icd11.foundation:768216194"
        ],
        "synonyms": [
          "pituitary insufficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005152"
    },
    {
      "id": 16072,
      "label": "pituitary deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019801",
          "Orphanet:101957",
          "icd11.foundation:292840069"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 5,
      "reference_id": "MONDO:0015127"
    }
  ],
  "children": [
    {
      "id": 8344,
      "label": "pituitary apoplexy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3496,
        19567
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1129",
          "EFO:1001108",
          "GARD:0019287",
          "ICD9:253.8",
          "MEDGEN:18489",
          "MESH:D010899",
          "MedDRA:10056447",
          "NCIT:C26853",
          "Orphanet:95613",
          "SCTID:237701005",
          "UMLS:C0032001",
          "icd11.foundation:1938573221"
        ],
        "synonyms": [
          "pituitary gland apoplexy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, potentially life-threatening disorder caused by acute ischemic infarction or hemorrhage in the pituitary gland. It is most often associated with the presence of a pituitary gland adenoma. Signs and symptoms include headache, vomiting, visual disturbances, and endocrine dysfunction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006908"
    },
    {
      "id": 16678,
      "label": "late-onset isolated ACTH deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19567
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020331",
          "MEDGEN:1651973",
          "Orphanet:199299",
          "UMLS:C4751433",
          "icd11.foundation:1651831896"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Late-onset isolated ACTH deficiency is a rare, acquired, pituitary hormone deficiency characterized by secondary adrenal insufficiency, with normal secretion of anterior pituitary hormones, except for ACTH. Patients present with weakness, fatigue, weight loss, anorexia, vomiting/nausea, hypoglycemia, and abnormally low serum ACTH and cortisol levels. Association with autoimmune disease such as Hashimoto's thyroiditis has been described."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016042"
    },
    {
      "id": 19568,
      "label": "primary hypophysitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2996,
        2997,
        19567,
        20389
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019281",
          "ICD9:253.8",
          "ICD9:279.49",
          "MEDGEN:575013",
          "MESH:D000069281",
          "NCIT:C132055",
          "Orphanet:95506",
          "SCTID:237706000",
          "UMLS:C0342410"
        ],
        "synonyms": [
          "autoimmune hypophysitis",
          "lymphocytic hypophysitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Immune-mediated inflammation of the pituitary gland often associated with other autoimmune diseases (e.g., hashimoto disease; graves disease; and addison disease)."
      },
      "child_count": 12,
      "reference_id": "MONDO:0019835"
    },
    {
      "id": 19573,
      "label": "iatrogenic or traumatic pituitary deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19567
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019290",
          "MEDGEN:575005",
          "Orphanet:95619",
          "UMLS:C0342400"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019845"
    }
  ],
  "roots": [
    {
      "id": 6876,
      "label": "hypopituitarism"
    },
    {
      "id": 16072,
      "label": "pituitary deficiency"
    }
  ]
}