{
  "id": 19647,
  "label": "growth hormone-producing pituitary gland neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019927",
  "properties": {
    "xrefs": [
      "GARD:0025150",
      "MEDGEN:866320",
      "NCIT:C7911",
      "UMLS:C4018860"
    ],
    "synonyms": [
      "Growth hormone-producing pituitary gland tumor",
      "Growth hormone-producing pituitary gland tumour",
      "growth hormone producing neoplasm of pituitary",
      "growth hormone producing neoplasm of pituitary gland",
      "growth hormone producing neoplasm of the pituitary",
      "growth hormone producing neoplasm of the pituitary gland",
      "growth hormone producing pituitary gland neoplasm",
      "growth hormone producing pituitary gland tumor",
      "growth hormone producing pituitary gland tumour",
      "growth hormone producing pituitary neoplasm",
      "growth hormone producing pituitary tumor",
      "growth hormone producing pituitary tumour",
      "growth hormone producing tumor",
      "growth hormone producing tumor of pituitary",
      "growth hormone producing tumor of pituitary gland",
      "growth hormone producing tumor of the pituitary",
      "growth hormone producing tumor of the pituitary gland",
      "growth hormone producing tumour",
      "growth hormone producing tumour of pituitary",
      "growth hormone producing tumour of pituitary gland",
      "growth hormone producing tumour of the pituitary",
      "growth hormone producing tumour of the pituitary gland",
      "growth hormone secreting neoplasm of pituitary",
      "growth hormone secreting neoplasm of pituitary gland",
      "growth hormone secreting neoplasm of the pituitary",
      "growth hormone secreting neoplasm of the pituitary gland",
      "growth hormone secreting pituitary gland neoplasm",
      "growth hormone secreting pituitary gland tumor",
      "growth hormone secreting pituitary gland tumour",
      "growth hormone secreting pituitary neoplasm",
      "growth hormone secreting pituitary tumor",
      "growth hormone secreting pituitary tumour",
      "growth hormone secreting tumor of pituitary",
      "growth hormone secreting tumor of pituitary gland",
      "growth hormone secreting tumor of the pituitary",
      "growth hormone secreting tumor of the pituitary gland",
      "growth hormone secreting tumour of pituitary",
      "growth hormone secreting tumour of pituitary gland",
      "growth hormone secreting tumour of the pituitary",
      "growth hormone secreting tumour of the pituitary gland",
      "growth hormone-producing pituitary gland neoplasm",
      "pituitary gland somatotropinoma",
      "pituitary somatotropinoma",
      "somatotroph neoplasm",
      "somatotroph tumor",
      "somatotroph tumour",
      "somatotropinoma",
      "somatotropinoma of pituitary",
      "somatotropinoma of pituitary gland",
      "somatotropinoma of the pituitary",
      "somatotropinoma of the pituitary gland"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces growth hormone."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7265,
      "label": "epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006858",
          "MEDGEN:277963",
          "MESH:D009375",
          "NCIT:C3709",
          "SCTID:118285006",
          "UMLS:C1368683"
        ],
        "synonyms": [
          "epithelial neoplasm",
          "epithelioma"
        ],
        "definition": "A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas."
      },
      "child_count": 24,
      "reference_id": "MONDO:0005626"
    },
    {
      "id": 17888,
      "label": "pituitary tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        4759,
        5314,
        7638,
        8247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021253",
          "ICD9:239.7",
          "MEDGEN:19326",
          "NCIT:C3330",
          "Orphanet:304055",
          "SCTID:127024001",
          "UMLS:C0032019"
        ],
        "synonyms": [
          "neoplasm of pituitary",
          "neoplasm of pituitary gland",
          "neoplasm of the pituitary",
          "neoplasm of the pituitary gland",
          "pituitary gland neoplasm",
          "pituitary gland tumor",
          "pituitary gland tumour",
          "pituitary neoplasm",
          "pituitary tumor",
          "tumor of pituitary",
          "tumor of pituitary gland",
          "tumor of the pituitary",
          "tumor of the pituitary gland",
          "tumour of pituitary",
          "tumour of pituitary gland",
          "tumour of the pituitary",
          "tumour of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland."
      },
      "child_count": 45,
      "reference_id": "MONDO:0017611"
    }
  ],
  "children": [
    {
      "id": 5697,
      "label": "growth hormone-producing pituitary gland carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4185,
        4246,
        4505,
        19647
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6256",
          "GARD:0023687",
          "MEDGEN:277331",
          "NCIT:C5963",
          "UMLS:C1334587"
        ],
        "synonyms": [
          "Growth hormone producing pituitary gland carcinoma",
          "Growth hormone-producing pituitary gland carcinoma",
          "malignant Growth hormone producing neoplasm of pituitary",
          "malignant Growth hormone producing neoplasm of pituitary gland",
          "malignant Growth hormone producing neoplasm of the pituitary",
          "malignant Growth hormone producing neoplasm of the pituitary gland",
          "malignant Growth hormone producing pituitary gland neoplasm",
          "malignant Growth hormone producing pituitary gland tumor",
          "malignant Growth hormone producing pituitary gland tumour",
          "malignant Growth hormone producing pituitary neoplasm",
          "malignant Growth hormone producing pituitary tumor",
          "malignant Growth hormone producing pituitary tumour",
          "malignant Growth hormone producing tumor",
          "malignant Growth hormone producing tumor of pituitary",
          "malignant Growth hormone producing tumor of pituitary gland",
          "malignant Growth hormone producing tumor of the pituitary",
          "malignant Growth hormone producing tumor of the pituitary gland",
          "malignant Growth hormone producing tumour",
          "malignant Growth hormone producing tumour of pituitary",
          "malignant Growth hormone producing tumour of pituitary gland",
          "malignant Growth hormone producing tumour of the pituitary",
          "malignant Growth hormone producing tumour of the pituitary gland",
          "malignant Growth hormone secreting neoplasm of pituitary",
          "malignant Growth hormone secreting neoplasm of pituitary gland",
          "malignant Growth hormone secreting neoplasm of the pituitary",
          "malignant Growth hormone secreting neoplasm of the pituitary gland",
          "malignant Growth hormone secreting pituitary gland neoplasm",
          "malignant Growth hormone secreting pituitary gland tumor",
          "malignant Growth hormone secreting pituitary gland tumour",
          "malignant Growth hormone secreting pituitary neoplasm",
          "malignant Growth hormone secreting pituitary tumor",
          "malignant Growth hormone secreting pituitary tumour",
          "malignant Growth hormone secreting tumor of pituitary",
          "malignant Growth hormone secreting tumor of pituitary gland",
          "malignant Growth hormone secreting tumor of the pituitary",
          "malignant Growth hormone secreting tumor of the pituitary gland",
          "malignant Growth hormone secreting tumour of pituitary",
          "malignant Growth hormone secreting tumour of pituitary gland",
          "malignant Growth hormone secreting tumour of the pituitary",
          "malignant Growth hormone secreting tumour of the pituitary gland",
          "malignant Somatotrophinoma of pituitary",
          "malignant Somatotrophinoma of pituitary gland",
          "malignant Somatotrophinoma of the pituitary gland",
          "malignant pituitary Somatotrophinoma",
          "malignant pituitary gland Somatotrophinoma",
          "malignant pituitary gland somatotropinoma",
          "malignant pituitary somatotropinoma",
          "malignant somatotropinoma of pituitary",
          "malignant somatotropinoma of pituitary gland",
          "malignant somatotropinoma of the pituitary",
          "malignant somatotropinoma of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces growth hormone. It may be associated with acromegaly."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003828"
    },
    {
      "id": 7790,
      "label": "growth hormone-producing pituitary gland adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7896,
        19647
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6255",
          "EFO:1000287",
          "GARD:0016850",
          "MEDGEN:82999",
          "NANDO:1200385",
          "NANDO:1200386",
          "NCIT:C7461",
          "Orphanet:96256",
          "SCTID:254957009",
          "UMLS:C0278864"
        ],
        "synonyms": [
          "GH cell adenoma",
          "Somatotrophinoma",
          "growth hormone producing adenoma of pituitary",
          "growth hormone producing adenoma of pituitary gland",
          "growth hormone producing adenoma of the pituitary gland",
          "growth hormone producing pituitary adenoma",
          "growth hormone producing pituitary gland adenoma",
          "growth hormone secreting adenoma of pituitary",
          "growth hormone secreting adenoma of pituitary gland",
          "growth hormone secreting adenoma of the pituitary",
          "growth hormone secreting adenoma of the pituitary gland",
          "growth hormone secreting pituitary gland adenoma",
          "growth hormone-producing adenoma",
          "growth hormone-producing pituitary gland adenoma",
          "somatotrope adenoma",
          "somatotropic adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma of the anterior lobe of the pituitary gland that produces growth hormone. The vast majority of cases are hormonally functioning and are associated with either gigantism or acromegaly."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006238"
    },
    {
      "id": 19936,
      "label": "pituitary gigantism",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8241,
        19647
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006506",
          "MEDGEN:6602",
          "MESH:D005877",
          "MedDRA:10018265",
          "NANDO:2100111",
          "NANDO:2200314",
          "NCIT:C93046",
          "Orphanet:99725",
          "SCTID:86073008",
          "UMLS:C0017547"
        ],
        "synonyms": [
          "hypophyseal gigantism",
          "infantile and juvenile forms of acromegaly",
          "gigantism"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "The condition of accelerated and excessive growth in children or adolescents who are exposed to excess human growth hormone before the closure of epiphyses. It is usually caused by somatotroph hyperplasia or a growth hormone-secreting pituitary adenoma. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020479"
    }
  ],
  "roots": [
    {
      "id": 7265,
      "label": "epithelial neoplasm"
    },
    {
      "id": 17888,
      "label": "pituitary tumor"
    }
  ]
}