{
  "id": 19662,
  "label": "Eisenmenger syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019944",
  "properties": {
    "xrefs": [
      "EFO:0009200",
      "GARD:0006323",
      "ICD10CM:I27.83",
      "MEDGEN:4479",
      "MESH:D004541",
      "MedDRA:10058554",
      "NCIT:C84390",
      "NORD:1081",
      "Orphanet:97214",
      "SCTID:445928005",
      "UMLS:C0013743",
      "icd11.foundation:581886860"
    ],
    "synonyms": [
      "Eisenmenger's syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Eisenmenger syndrome (ES) is an form of pulmonary arterial hypertension (PAH) associated with unoperated congenital heart disease and is characterized by congenital heart malformations with reversed or bi-directional shunting through an intra-cardiac or intervascular (usually aorto-pulmonary) communication with the development of PAH."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 16614,
      "label": "pulmonary arterial hypertension",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0001361",
          "GARD:0007501",
          "MEDGEN:425404",
          "MESH:D000081029",
          "MedDRA:10064911",
          "NANDO:1200425",
          "NANDO:2100103",
          "NANDO:2200298",
          "NORD:1634",
          "Orphanet:182090",
          "Orphanet:422",
          "SCTID:11399002",
          "UMLS:C2973725",
          "icd11.foundation:1931148955"
        ],
        "synonyms": [
          "PAH",
          "pulmonary arterial hypertension",
          "PAH with overt features of venous/capillaries involvement",
          "PVOD/PCH",
          "PPH",
          "idiopathic pulmonary hypertension"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Pulmonary arterial hypertension (PAH) is a group of diseases characterized by mean pulmonary artery pressure >20 mmHg and elevated pulmonary arterial resistance leading to right heart failure. PAH is progressive and potentially fatal. PAH may be idiopathic and/ or familial, have overt features of venous/capillary involvement (pulmonary veno-occlusive disease, PVOD/pulmonary capillary hemangiomatosis, PCH), induced by drug or toxin (drug-or toxin-induced PAH), or associated with other diseases like congenital heart disease, connective tissue disease, HIV, schistosomiasis, portal hypertension (PAH associated with other disease)."
      },
      "child_count": 5,
      "reference_id": "MONDO:0015924"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 16614,
      "label": "pulmonary arterial hypertension"
    }
  ]
}