{
  "id": 19673,
  "label": "encephalitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019956",
  "properties": {
    "xrefs": [
      "DOID:9588",
      "ICD10CM:A85",
      "ICD9:323.0",
      "ICD9:323.8",
      "ICD9:323.9",
      "MEDGEN:4027",
      "MESH:D004660",
      "MedDRA:10014581",
      "NCIT:C26760",
      "Orphanet:97275",
      "SCTID:45170000",
      "UMLS:C0014038"
    ],
    "synonyms": [
      "brain inflammation"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An acute inflammatory process affecting the brain parenchyma. Causes include viral infections and less frequently bacterial infections, toxins, and immune-mediated processes."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6880,
      "label": "encephalomyelitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:640",
          "EFO:0001423",
          "ICD9:323.9",
          "MEDGEN:8603",
          "MESH:D004679",
          "NCIT:C34580",
          "SCTID:62950007",
          "UMLS:C0014070"
        ],
        "synonyms": [
          "central nervous system inflammation",
          "encephalitis and/or myelitis",
          "inflammation of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Inflammation of the brain and the spinal cord."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005156"
    },
    {
      "id": 7209,
      "label": "brain disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:936",
          "EFO:0005774",
          "ICD9:348.3",
          "ICD9:348.30",
          "ICD9:348.8",
          "ICD9:348.9",
          "MEDGEN:14214",
          "MESH:D001927",
          "NCIT:C96413",
          "SCTID:81308009",
          "UMLS:C0006111"
        ],
        "synonyms": [
          "brain disease",
          "brain disease or disorder",
          "disease of brain",
          "disease or disorder of brain",
          "disorder of brain",
          "encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease affecting the brain or part of the brain."
      },
      "child_count": 71,
      "reference_id": "MONDO:0005560"
    },
    {
      "id": 20092,
      "label": "acute disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24492
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:799.89",
          "MEDGEN:1738",
          "MESH:D000208",
          "SCTID:2704003",
          "UMLS:C0001314"
        ],
        "synonyms": [
          "acute disease",
          "acute diseases",
          "disease, acute"
        ],
        "definition": "Disease having a short and relatively severe course."
      },
      "child_count": 119,
      "reference_id": "MONDO:0020683"
    }
  ],
  "children": [
    {
      "id": 3957,
      "label": "post-vaccinal encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13664",
          "GARD:0023010",
          "ICD9:323.51",
          "MEDGEN:152946",
          "SCTID:31367003",
          "UMLS:C0751101"
        ],
        "synonyms": [
          "encephalitis following immunisation procedures",
          "encephalitis following immunization procedures"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute or subacute inflammatory process of the central nervous system characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include confusion, somnolence, fever, nuchal rigidity, and involuntary movements. The illness may progress to coma and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0001773"
    },
    {
      "id": 7457,
      "label": "meningoencephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10554",
          "EFO:0007364",
          "GARD:0024242",
          "MEDGEN:6301",
          "MESH:D008590",
          "NCIT:C34813",
          "SCTID:7125002",
          "UMLS:C0025309"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Inflammation of the meninges and brain, generally secondary to an infectious cause. Pathogens may be bacterial, viral, fungal, or protozoan."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005845"
    },
    {
      "id": 16388,
      "label": "limbic encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080741",
          "GARD:0008742",
          "ICD9:323.9",
          "MEDGEN:137895",
          "MESH:D020363",
          "Orphanet:163892",
          "SCTID:230192003",
          "UMLS:C0338430"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of autoimmune conditions characterized by inflammation of the limbic system and other parts of the brain.The cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however,symptoms may also include confusion, psychiatric symptoms, and seizures.The symptomstypically develop over a few weeks or months, but they may evolve over a few days. Limbic encephalitis is often associated with an underlying neoplasm (paraneoplastic limbic encephalitis); however some cases never have a neoplasm identified (non-paraneoplastic limbic encephalitis). Delayed diagnosis is common, but improvements are being made to assist in early detection. Various tests including imaging studies (MRI, PET) laboratory tests (CSF analysis), and tests that measure the electrical activity of the brain (EEG) may be utilized to confirm a diagnosis. Treatment includes removal of the neoplasm (if identified) and immunotherapy."
      },
      "child_count": 6,
      "reference_id": "MONDO:0015588"
    },
    {
      "id": 19721,
      "label": "infectious encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19673,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025151",
          "ICD9:049.8",
          "ICD9:323.4",
          "MEDGEN:108917",
          "MESH:D000069544",
          "NCIT:C79550",
          "SCTID:312215006",
          "UMLS:C0596773"
        ],
        "synonyms": [
          "encephalitis infection"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi."
      },
      "child_count": 20,
      "reference_id": "MONDO:0020067"
    },
    {
      "id": 20055,
      "label": "autoimmune encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2996,
        19673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0011979",
          "MEDGEN:1804547",
          "NANDO:2100248",
          "NANDO:2200902",
          "NCIT:C122414",
          "Orphanet:622014",
          "SCTID:95643007",
          "UMLS:C5671289",
          "icd11.foundation:241281019"
        ],
        "synonyms": [
          "autoimmune encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Inflammation of the brain secondary to an immune response triggered by the body itself."
      },
      "child_count": 4,
      "reference_id": "MONDO:0020640"
    },
    {
      "id": 20322,
      "label": "anti-NMDA receptor encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020513",
          "MEDGEN:458943",
          "MESH:D060426",
          "NANDO:2201317",
          "NCIT:C94853",
          "Orphanet:217253",
          "SCTID:716684004",
          "UMLS:C2986717",
          "icd11.foundation:1568915618"
        ],
        "synonyms": [
          "anti-NMDA receptor encephalitis",
          "limbic encephalitis with N-methyl-D-aspartate receptor antibodies",
          "limbic encephalitis with NMDA receptor antibodies"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An autoimmune acute encephalitis caused by antibodies against the glutamate NMDA receptor. It usually affects females and in the majority of cases it is associated with the presence of a tumor, most commonly an ovarian teratoma. The presence of a tumor in patients with this form of encephalitis implies that the latter is a paraneoplastic syndrome. It is manifested with psychiatric symptoms and epileptic seizures. It is a potentially lethal disorder; however, it is usually reversible with the prompt removal of the tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021081"
    },
    {
      "id": 25142,
      "label": "paraneoplastic isolated brainstem encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022499",
          "MEDGEN:1842767",
          "Orphanet:624190",
          "UMLS:C5680406"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0850104"
    }
  ],
  "roots": [
    {
      "id": 6880,
      "label": "encephalomyelitis"
    },
    {
      "id": 7209,
      "label": "brain disorder"
    },
    {
      "id": 20092,
      "label": "acute disease"
    }
  ]
}