{
  "id": 19676,
  "label": "VIPoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019960",
  "properties": {
    "xrefs": [
      "DOID:5574",
      "GARD:0003787",
      "ICD9:239.7",
      "ICDO:8155/1",
      "MEDGEN:41532",
      "MESH:D003969",
      "MedDRA:10047430",
      "NANDO:2200394",
      "NCIT:C26749",
      "Orphanet:97282",
      "SCTID:253005002",
      "UMLS:C0011993",
      "icd11.foundation:20634476"
    ],
    "synonyms": [
      "Diarrheogenic islet cell tumor",
      "Diarrheogenic islet cell tumour",
      "VIP producing neoplasm",
      "VIP- secreting neoplasm",
      "VIP- secreting tumor",
      "VIP- secreting tumour",
      "VIP-producing NET",
      "VIP-producing neuroendocrine tumor",
      "VIP-producing neuroendocrine tumour",
      "VIP-secreting tumor",
      "VIP-secreting tumour",
      "VIPoma",
      "Verner-Morrison syndrome",
      "malignant vasoactive intestinal peptide-secreting tumour",
      "vasoactive intestinal peptide producing neoplasm",
      "vasoactive intestinal peptide producing tumor",
      "vasoactive intestinal peptide producing tumour",
      "vasoactive intestinal peptide secreting neoplasm",
      "vasoactive intestinal peptide-secreting tumour",
      "WDHA syndrome",
      "pancreatic cholera",
      "pancreatic vipoma",
      "vasoactive intestinal peptide (VIP) tumor",
      "vasoactive intestinal peptide (VIP) tumour",
      "vasoactive intestinal peptide-producing tumor",
      "vasoactive intestinal peptide-producing tumour",
      "watery diarrhea, hypokalemia, and achlorhydria syndrome",
      "watery diarrhea-hypokalemia-achlorhydria syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "VIPoma is an extremely rare type of pancreatic neuroendocrine tumor that secretes vasoactive intestinal polypeptide (VIP) leading to the manifestations of watery diarrhea, hypokalemia and achlorhydia or hypochhlorhydia (known as WDHA syndrome)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        7431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000045",
          "GARD:0013034",
          "ICDO:8150/1",
          "MEDGEN:277875",
          "NCIT:C27720",
          "ONCOTREE:PANET",
          "Orphanet:97253",
          "UMLS:C1337011"
        ],
        "synonyms": [
          "islet cell tumor",
          "islet cell tumors - pancreas",
          "islet cell tumors of the pancreas",
          "islet cell tumour",
          "islet cell tumours - pancreas",
          "islet cell tumours of the pancreas",
          "pancreatic NET",
          "pancreatic neuroendocrine tumor",
          "well differentiated pancreatic endocrine neoplasm",
          "well differentiated pancreatic endocrine tumor",
          "well differentiated pancreatic endocrine tumour",
          "well-differentiated NEN of pancreas",
          "well-differentiated neuroendocrine neoplasm of pancreas",
          "well-differentiated pancreatic NEN",
          "well-differentiated pancreatic neuroendocrine neoplasm",
          "PANET",
          "neuroendocrine tumor of pancreas",
          "neuroendocrine tumour of pancreas",
          "pancreatic endocrine tumor",
          "pancreatic endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. They can be functional, exhibiting a hormonal hypersecretion syndrome, but can be non-functional presenting with non-specific symptoms and include insulinoma, glucagonoma, VIPoma, somatostatinoma (SSoma), PPoma and Zollinger-Ellison syndrome (ZES, or gastrinoma) and other ectopic hormone producing tumors (such as GRFoma)."
      },
      "child_count": 22,
      "reference_id": "MONDO:0019954"
    }
  ],
  "children": [
    {
      "id": 5513,
      "label": "small intestinal vasoactive intestinal peptide producing tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4994,
        19676
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5740",
          "GARD:0023590",
          "MEDGEN:277655",
          "NCIT:C27455",
          "UMLS:C1336009"
        ],
        "synonyms": [
          "small intestinal VIP-producing NET",
          "small intestinal VIP-producing neuroendocrine tumor",
          "small intestinal VIP-producing neuroendocrine tumour",
          "small intestinal VIPoma",
          "small intestinal vasoactive intestinal peptide producing tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine tumor that arises from the small intestine and produces vasoactive intestinal peptide."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003621"
    },
    {
      "id": 5514,
      "label": "pancreatic vasoactive intestinal peptide producing tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19676
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5741",
          "GARD:0023591",
          "MEDGEN:453212",
          "NCIT:C27454",
          "UMLS:C2033037"
        ],
        "synonyms": [
          "pancreatic VIP producing NET",
          "pancreatic VIP producing neoplasm",
          "pancreatic VIP producing tumor",
          "pancreatic VIP-producing neuroendocrine tumor",
          "pancreatic VIP-producing neuroendocrine tumour",
          "pancreatic vasoactive intestinal peptide producing neoplasm",
          "pancreatic vasoactive intestinal peptide producing tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually malignant pancreatic neuroendocrine tumor producing vasoactive intestinal peptide (VIP). It may or may not be associated with inappropriate secretion of VIP and an associated clinical syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003622"
    }
  ],
  "roots": [
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor"
    }
  ]
}