{
  "id": 19679,
  "label": "thymic neuroendocrine tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019964",
  "properties": {
    "xrefs": [
      "GARD:0019361",
      "MEDGEN:234428",
      "NCIT:C6430",
      "ONCOTREE:TNET",
      "Orphanet:97289",
      "UMLS:C1336746"
    ],
    "synonyms": [
      "neuroendocrine neoplasm of thymus",
      "thymus NET",
      "thymus neuroendocrine neoplasm",
      "thymus neuroendocrine tumor",
      "thymus neuroendocrine tumor, well differentiated, low or intermediate grade",
      "thymus neuroendocrine tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Thymic endocrine tumor is a rare, malignant, primary thymic neoplasm originating from neuroendocrine cells, presenting as a mass within the anterior mediastinum. Patients typically present with nonspecific symptoms, such as chest pain, cough, shortness of breath, or in some cases, superior vena cava syndrome, although patients could be asymptomatic during the early stages or present with multiple endocrine neoplasia type I. Ectopic production of ACTH and serotonin can lead to Cushing syndrome and carcinoid sydrome, respectively."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6916,
      "label": "thymus neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        4440,
        5325
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002626",
          "GARD:0019767",
          "ICD9:239.89",
          "MEDGEN:811424",
          "NCIT:C3412",
          "ONCOTREE:THYMUS",
          "Orphanet:100100",
          "SCTID:127231009",
          "UMLS:C3714644"
        ],
        "synonyms": [
          "Thymus neoplasm",
          "Thymus tumor",
          "Thymus tumour",
          "neoplasm of Thymus",
          "neoplasm of the Thymus",
          "neoplasm of thymus",
          "thymic neoplasm",
          "thymic tumor",
          "thymic tumour",
          "thymus neoplasm (disease)",
          "thymus tumor",
          "thymus tumour",
          "tumor of Thymus",
          "tumor of the Thymus",
          "tumor of thymus",
          "tumour of Thymus",
          "tumour of the Thymus",
          "tumour of thymus",
          "THYMUS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm that affects the thymus. Representative examples include thymoma and carcinoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005197"
    },
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:169",
          "EFO:1001901",
          "GARD:0009316",
          "ICD9:209",
          "ICD9:209-209",
          "ICD9:239.7",
          "MEDGEN:64652",
          "MESH:D018358",
          "NCIT:C188218",
          "NCIT:C3809",
          "Orphanet:877",
          "SCTID:255046005",
          "UMLS:C0206754"
        ],
        "synonyms": [
          "APUDoma",
          "neuroendocrine neoplasm",
          "neuroendocrine tumor",
          "neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Endocrine tumors, also referred to as neuroendocrine tumors (NETs), are defined by a common phenotype which is characterized by the expression of general markers (neuron specific enolase, chromogranin, synaptophysin) and hormone secretion products. These tumors may be localized in any part of the body and are generally discovered in non-specific situations, i.e. not immediately suggestive of NETs (tests for inherited predisposition to tumors or for a clinical syndrome caused by abnormal hormone secretion)."
      },
      "child_count": 14,
      "reference_id": "MONDO:0019496"
    }
  ],
  "children": [
    {
      "id": 19965,
      "label": "thymic neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        7956,
        19679
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019696",
          "MEDGEN:900590",
          "NCIT:C171031",
          "Orphanet:99869",
          "SCTID:716653001",
          "UMLS:C2210965",
          "icd11.foundation:381956131"
        ],
        "synonyms": [
          "neuroendocrine carcinoma of thymus",
          "thymic neuroendocrine carcinoma",
          "thymus neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Thymic neuroendocrine carcinoma is a type of thymic epithelial neoplasm displaying evidence of neuroendocrine differentiation."
      },
      "child_count": 15,
      "reference_id": "MONDO:0020516"
    }
  ],
  "roots": [
    {
      "id": 6916,
      "label": "thymus neoplasm"
    },
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm"
    }
  ]
}