{
  "id": 19701,
  "label": "immunotactoid glomerulopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019991",
  "properties": {
    "xrefs": [
      "GARD:0012048",
      "ICD9:583.9",
      "MEDGEN:1684714",
      "NCIT:C158968",
      "NCIT:C96182",
      "Orphanet:97567",
      "SCTID:73305009",
      "UMLS:C5202806"
    ],
    "synonyms": [
      "FGN",
      "Immunotactoid glomerulonephritis",
      "fibrillary glomerulonephritis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "Immunotactoid glomerulopathy (ITG) is a very rare condition characterized by glomerular accumulation of microtubules in the mesangium and the glomerular basement membrane, that mainly presents with proteinuria, micro-hematuria, nephrotic syndrome, renal insufficiency and hematologic malignancy. ITG and non-amyloid fibrillary glomerulopathy (non-amyloid FGP) are often grouped together as pathogenetically related diseases."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4542,
      "label": "glomerulonephritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3410,
        19482
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2921",
          "GARD:0006516",
          "HP:0000099",
          "ICD9:583.9",
          "MEDGEN:6616",
          "MESH:D005921",
          "NCIT:C26784",
          "SCTID:36171008",
          "UMLS:C0017658"
        ],
        "synonyms": [
          "glomerular nephritis",
          "glomerulonephritis",
          "glomerulonephritis (disease)",
          "nephritis of renal glomerulus",
          "renal glomerulus nephritis",
          "bright's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A renal disorder characterized by damage in the glomeruli. It may be acute or chronic, focal or diffuse, and it may lead to renal failure. Causes include autoimmune disorders, infections, diabetes, and malignancies."
      },
      "child_count": 40,
      "reference_id": "MONDO:0002462"
    },
    {
      "id": 19398,
      "label": "immunotactoid or fibrillary glomerulopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19482
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012741",
          "MEDGEN:1842578",
          "Orphanet:91137",
          "UMLS:C5680195"
        ],
        "synonyms": [
          "Immunotactoid or fibrillary glomerulonephritis",
          "fibrillary glomerulonephritis and immunotactoid glomerulopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A group of very rare glomerular diseases, composed of immunotactoid glomerulopathy (ITG) and non-amyloid fibrillary glomerulopathy (non-amyloid FGP), that are characterized by mesangial deposition of monoclonal microtubular or polyclonal fibrillar deposits. Both present clinically with nephrotic range proteinuria, hematuria and renal insufficiency leading to renal failure in many cases. ITG is more likely to manifest with underlying lymphoproliferative disease, hypocomplementemia, dysproteinemia, monoclonal gammopathy or occult cryoglobulinemia. Non-amyloid FGP is 10 times more frequent than ITG."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019605"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4542,
      "label": "glomerulonephritis"
    },
    {
      "id": 19398,
      "label": "immunotactoid or fibrillary glomerulopathy"
    }
  ]
}