{
  "id": 19705,
  "label": "peripheral resistance to thyroid hormones",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019995",
  "properties": {
    "xrefs": [
      "GARD:0012734",
      "MEDGEN:902322",
      "Orphanet:97927",
      "SCTID:718193005",
      "UMLS:C4273673"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Peripheral resistance to thyroid hormones may be a cause of permanent congenital hypothyroidism, a permanent thyroid hormone deficiency that is present from birth."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 16929,
      "label": "peripheral hypothyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16926
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025073",
          "MEDGEN:1843430",
          "Orphanet:226310",
          "UMLS:C5704669"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Peripheral hypothyroidism is a type of permanent congenital hypothyroidism, a permanent thyroid hormone deficiency that is present from birth, that results from peripheral defects in thyroid hormone metabolism."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016412"
    }
  ],
  "children": [
    {
      "id": 13412,
      "label": "congenital nongoitrous hypothyroidism 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2710,
        19705
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070127",
          "GARD:0024862",
          "MEDGEN:424853",
          "MESH:C567935",
          "OMIM:609893",
          "UMLS:C2940785"
        ],
        "synonyms": [
          "CHNG3",
          "hypothyroidism, congenital, nongoitrous, 3",
          "resistance to thyrotropin",
          "thyrotropin resistance"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A congenital hypothyroidism characterized by autosomal dominant inheritance of resistance to thyrotropin that has material basis in variation in the chromosome region 15q25.3-q26.1."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012360"
    },
    {
      "id": 14775,
      "label": "congenital nongoitrous hypothyroidism 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2710,
        19705
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070128",
          "GARD:0024946",
          "MEDGEN:482447",
          "OMIM:614450",
          "UMLS:C3280817"
        ],
        "synonyms": [
          "CHNG6",
          "THRA hypothyroidism, congenital, nongoitrous",
          "hypothyroidism, congenital, nongoitrous caused by mutation in THRA",
          "hypothyroidism, congenital, nongoitrous, 6",
          "hypothyroidism, congenital, nongoitrous, type 6"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any hypothyroidism, congenital, nongoitrous in which the cause of the disease is a mutation in the THRA gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013757"
    }
  ],
  "roots": [
    {
      "id": 16929,
      "label": "peripheral hypothyroidism"
    }
  ]
}