{
  "id": 19721,
  "label": "infectious encephalitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020067",
  "properties": {
    "xrefs": [
      "GARD:0025151",
      "ICD9:049.8",
      "ICD9:323.4",
      "MEDGEN:108917",
      "MESH:D000069544",
      "NCIT:C79550",
      "SCTID:312215006",
      "UMLS:C0596773"
    ],
    "synonyms": [
      "encephalitis infection"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 19673,
      "label": "encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6880,
        7209,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9588",
          "ICD10CM:A85",
          "ICD9:323.0",
          "ICD9:323.8",
          "ICD9:323.9",
          "MEDGEN:4027",
          "MESH:D004660",
          "MedDRA:10014581",
          "NCIT:C26760",
          "Orphanet:97275",
          "SCTID:45170000",
          "UMLS:C0014038"
        ],
        "synonyms": [
          "brain inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute inflammatory process affecting the brain parenchyma. Causes include viral infections and less frequently bacterial infections, toxins, and immune-mediated processes."
      },
      "child_count": 21,
      "reference_id": "MONDO:0019956"
    },
    {
      "id": 21534,
      "label": "central nervous system infectious disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657,
        19708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001456",
          "GARD:0025438",
          "ICD9:349.89",
          "MEDGEN:1684837",
          "MESH:D002494",
          "NCIT:C27582",
          "SCTID:128117002",
          "UMLS:C4759823"
        ],
        "synonyms": [
          "central nervous system infectious disease",
          "central nervous system infectious disorder",
          "infectious disease of central nervous system",
          "central nervous system infection",
          "infections, central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An infectious process that affects the brain and/or spinal cord. Representative examples include encephalitis, poliomyelitis, arachnoiditis, and meningitis."
      },
      "child_count": 24,
      "reference_id": "MONDO:0024619"
    }
  ],
  "children": [
    {
      "id": 2818,
      "label": "primary amebic meningoencephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        19721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050242",
          "GARD:0009554",
          "ICD10CM:B60.2",
          "MEDGEN:81253",
          "MESH:C535275",
          "SCTID:721816008",
          "UMLS:C0300934"
        ],
        "synonyms": [
          "Naegleria fowleri infection",
          "infections, Naegleria fowleri"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A infectious disease involving the Naegleria fowleri."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000290"
    },
    {
      "id": 2819,
      "label": "granulomatous amebic encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        19721,
        20742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050246",
          "GARD:0012651",
          "ICD9:323.2",
          "MEDGEN:572559",
          "SCTID:230187000",
          "UMLS:C0338428"
        ],
        "synonyms": [
          "Acanthamoeba encephalitis",
          "Acanthamoeba granulomatous encephalitis",
          "granulomatous amebic encephalitis due to Acanthamoeba"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Granulomatous amebic encephalitis is a life-threatening infection of the brain caused by the free-living amoebae Acanthamoeba spp., Balamuthia mandrillaris and Sappinia pedata. Acanthamoeba species, are commonly found in lakes, swimming pools, tap water, and heating and air conditioning units. The disease affects immunocompromised people and is very serious. Symptoms include mental status changes, loss of coordination, fever, muscular weakness or partial paralysis affecting one side of the body, double vision, sensitivity to light and other neurologic problems. The diagnosis is difficult and is often made at advanced stages. Tests useful in the diagnosis include brain scans, biopsies, or spinal taps and in disseminated disease, biopsy of the involved sites and testing by the laboratory experts. Early diagnosis is important for the prognosis. No single drug is effective; hence multiple antibiotics are needed for successful treatment. A combination of surgical and medical interventions involving multiple specialty experts is required to prevent death and morbidity in survivors."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000291"
    },
    {
      "id": 3206,
      "label": "syphilitic encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8423,
        19721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10081",
          "GARD:0022849",
          "ICD9:094.81",
          "MEDGEN:509177",
          "SCTID:26135000",
          "UMLS:C0153168"
        ],
        "synonyms": [
          "Treponema caused encephalitis",
          "Treponema encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An encephalitis caused by infection with Treponema."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000937"
    },
    {
      "id": 7432,
      "label": "Kluver-Bucy syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3406,
        4370,
        19721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2510",
          "EFO:0007335",
          "GARD:0006840",
          "MEDGEN:124361",
          "MESH:D020232",
          "MedDRA:10066431",
          "NCIT:C84802",
          "NORD:1338",
          "Orphanet:157823",
          "SCTID:10651001",
          "UMLS:C0270707"
        ],
        "synonyms": [
          "KLüver-Bucy syndrome",
          "KLuever-Bucy syndrome",
          "Kluver Bucy syndrome",
          "bilateral temporal lobe disorder",
          "memory loss, extreme sexual behavior, placidity, and visual distractibility",
          "post-encephalitic Kluver Bucy syndrome (type)",
          "post-traumatic Kluver Bucy syndrome (type)",
          "syndrome, Kluver-Bucy",
          "temporal lobectomy behavior syndrome",
          "temporal lobectomy behaviour syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Kluver Bucy syndrome is a rare behavioral impairment characterized by inappropriate sexual behaviors and mouthing of objects. Other signs and symptoms include diminished ability to visually recognize objects,loss of normal fear and anger responses, memory loss, distractibility, seizures, and dementia. It is associated with damage to the anterior temporal lobes of the brain. Cases have been reported in association with herpes encephalitis and head trauma. Treatment is symptomatic and may include the use of psychotropic medications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005817"
    },
    {
      "id": 7600,
      "label": "viral encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19721,
        21351,
        24062
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:646",
          "EFO:0007538",
          "GARD:0019433",
          "MEDGEN:116719",
          "MedDRA:10058805",
          "NCIT:C35302",
          "Orphanet:98252",
          "SCTID:34476008",
          "UMLS:C0243010"
        ],
        "synonyms": [
          "Viruses caused encephalitis",
          "Viruses encephalitis",
          "viral encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Encephalitis resulting from viral infection."
      },
      "child_count": 36,
      "reference_id": "MONDO:0006009"
    },
    {
      "id": 16870,
      "label": "progressive multifocal leukoencephalopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:643",
          "EFO:0007455",
          "GARD:0007468",
          "ICD10CM:A81.2",
          "ICD9:046.3",
          "MEDGEN:7327",
          "MESH:D007968",
          "MedDRA:10036807",
          "NANDO:1200205",
          "NCIT:C26815",
          "NORD:1616",
          "Orphanet:217260",
          "SCTID:22255007",
          "UMLS:C0023524",
          "icd11.foundation:902939755"
        ],
        "synonyms": [
          "PML",
          "progressive multifocal leukoencephalitis",
          "leukoencephalopathy, progressive multifocal"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but itrarelycauses symptoms unless the immune system becomes severely weakened.The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as Hodgkins disease, lymphoma, and sarcoidosis. PML is most common among individuals with acquired immune deficiency syndrome (AIDS)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016318"
    },
    {
      "id": 17403,
      "label": "acute necrotizing encephalopathy of childhood",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017257",
          "MEDGEN:1641610",
          "Orphanet:263524",
          "SCTID:763310000",
          "UMLS:C4706387"
        ],
        "synonyms": [
          "ANEC",
          "isolated ANE",
          "isolated acute necrotizing encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Acute necrotizing encephalopathy of childhood is a rare neurologic disease characterized by a rapid onset of seizures, an altered state of consciousness, neurologic decline, and variable degrees of hepatic dysfunction following a respiratory or gastrointesitnal infection (e.g. mycoplasma, influenza virus) in a previously healthy child. Brain MRI of patients reveals bilateral, multiple, symmetrical lesions predominantly observed in thalami and brainstem, but also in periventricular white matter and cerebellum in some cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016991"
    },
    {
      "id": 18141,
      "label": "Hendra virus infection",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021448",
          "MEDGEN:1388276",
          "Orphanet:324632",
          "UMLS:C4505487"
        ],
        "synonyms": [
          "Hendra henipavirus caused disease or disorder",
          "Hendra henipavirus disease or disorder",
          "Hendra henipavirus infectious disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Hendra virus infection is a rare viral infection disorder caused by the Hendra virus characterized by onset of flu-like symptoms (fever, myalgia, headaches, lethargy) approximately one week after having been in close contact with bodily fluids of infected horses. Neurological manifestations (e.g. vertigo, confusion, ataxia) and progressive respiratory failure, leading to death, have also been reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017942"
    },
    {
      "id": 19211,
      "label": "Mycoplasma encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19721,
        29222
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019040",
          "MEDGEN:1636101",
          "Orphanet:83482",
          "UMLS:C4707240"
        ],
        "synonyms": [
          "Mycoplasma pneumoniae caused infectious encephalitis",
          "Mycoplasma pneumoniae infectious encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Mycoplasma encephalitis is a rare infectious encephalitis characterized by an acute onset of neurological signs and symptoms (e.g. altered consciousness, seizures, headaches, meningeal signs, behavioral changes) due to bacterial infection by Mycoplasma pneumoniae. Patients typically present unspecific signs and symptoms, such as fever, nausea, vomiting, fatigue, prior to onset of neurological manifestations and frequently have a history of a respiratory tract infection (e.g. pneumonia, bronchiolitis, pharyngitis)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019377"
    },
    {
      "id": 19722,
      "label": "postinfectious encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19721,
        20718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10993",
          "GARD:0025152",
          "ICD9:323.6",
          "MEDGEN:581376",
          "MedDRA:10057235",
          "Orphanet:98253",
          "SCTID:192727001",
          "UMLS:C0393459"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 14,
      "reference_id": "MONDO:0020068"
    }
  ],
  "roots": [
    {
      "id": 19673,
      "label": "encephalitis"
    },
    {
      "id": 21534,
      "label": "central nervous system infectious disorder"
    }
  ]
}