{
  "id": 19727,
  "label": "myeloproliferative neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020076",
  "properties": {
    "xrefs": [
      "DOID:2226",
      "EFO:0002428",
      "GARD:0009319",
      "ICD9:238.79",
      "ICDO:9960/3",
      "ICDO:9975/1",
      "MEDGEN:220955",
      "MedDRA:10028576",
      "NCIT:C4345",
      "ONCOTREE:MPN",
      "Orphanet:98274",
      "SCTID:425333006",
      "UMLS:C1292778"
    ],
    "synonyms": [
      "CMPD",
      "MPD",
      "MPN",
      "chronic myeloproliferative disease",
      "chronic myeloproliferative disorder",
      "chronic myeloproliferative neoplasm",
      "myeloproliferative disorder",
      "myeloproliferative neoplasm",
      "myeloproliferative neoplasm, chronic",
      "myeloproliferative tumor",
      "myeloproliferative tumour",
      "CMPD, U",
      "chronic myeloproliferative disorders",
      "myeloproliferative neoplasms"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 6892,
      "label": "myeloid neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070004",
          "EFO:0002427",
          "GARD:0024160",
          "ICDO:9975/1",
          "MEDGEN:445430",
          "NCIT:C9290",
          "ONCOTREE:MYELOID",
          "UMLS:C2939461"
        ],
        "synonyms": [
          "myeloid malignancy",
          "myeloid neoplasm",
          "myeloid tumor",
          "myeloid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Proliferation of myeloid cells originating from a primitive stem cell."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005170"
    },
    {
      "id": 16513,
      "label": "myeloid hemopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020130",
          "MEDGEN:1842523",
          "Orphanet:171895",
          "UMLS:C5680514"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0015756"
    },
    {
      "id": 20376,
      "label": "bone marrow cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        4262,
        7055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025293",
          "MEDGEN:438070",
          "NCIT:C35501",
          "UMLS:C2703042"
        ],
        "synonyms": [
          "bone marrow cancer",
          "cancer of bone marrow",
          "malignant bone marrow neoplasm",
          "malignant bone marrow tumor",
          "malignant bone marrow tumour",
          "malignant neoplasm of bone marrow"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Malignant neoplasms that either originate from the bone marrow (e.g. myeloid leukemias) or involve the bone marrow as secondary-metastatic tumors (e.g. metastatic carcinomas to the bone marrow). --2003"
      },
      "child_count": 3,
      "reference_id": "MONDO:0021138"
    }
  ],
  "children": [
    {
      "id": 6429,
      "label": "myeloid leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
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          "GARD:0008226",
          "ICD10CM:C92",
          "ICD9:205",
          "ICD9:205.80",
          "ICD9:205.9",
          "ICD9:205.90",
          "ICDO:9860/3",
          "MEDGEN:7320",
          "MESH:D007951",
          "NCIT:C3172",
          "SCTID:188732008",
          "UMLS:C0023470"
        ],
        "synonyms": [
          "leukaemia granulocytic",
          "leukaemia myeloid",
          "leukemia granulocytic",
          "leukemia myelogenous",
          "leukemia myeloid",
          "leukemia, granulocytic, malignant",
          "myelocytic leukaemia",
          "myelocytic leukemia",
          "myelogenous leukaemia",
          "myelogenous leukemia",
          "myeloid leukemia",
          "non-lymphoblastic leukaemia",
          "non-lymphoblastic leukemia",
          "non-lymphocytic leukaemia",
          "non-lymphocytic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004643"
    },
    {
      "id": 6763,
      "label": "essential thrombocythemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4365,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2224",
          "EFO:0000479",
          "GARD:0006594",
          "ICD10CM:D47.3",
          "ICD9:238.71",
          "ICDO:9962/3",
          "MEDGEN:11797",
          "MESH:D013920",
          "MedDRA:10015493",
          "NANDO:2100194",
          "NANDO:2200655",
          "NCIT:C3407",
          "NORD:1110",
          "ONCOTREE:ET",
          "Orphanet:3318",
          "SCTID:109994006",
          "UMLS:C0040028"
        ],
        "synonyms": [
          "ET",
          "essential thrombocytemia",
          "essential thrombocythemia",
          "essential thrombocytosis",
          "primary thrombocythemia",
          "primary thrombocytosis",
          "idiopathic thrombocythemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage. It is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage. (WHO, 2008)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005029"
    },
    {
      "id": 7847,
      "label": "myelodysplastic/myeloproliferative neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4972",
          "EFO:1000388",
          "GARD:0024368",
          "ICDO:9975/3",
          "MEDGEN:226981",
          "NCIT:C27262",
          "ONCOTREE:MDS%2FMPN",
          "SCTID:445738007",
          "UMLS:C1301355"
        ],
        "synonyms": [
          "MDS-MPD",
          "MDS/MPD",
          "myelodysplastic myeloproliferative disease",
          "myelodysplastic/myeloproliferative disease",
          "myelodysplastic/myeloproliferative diseases",
          "myelodysplastic/myeloproliferative disorder",
          "myelodysplastic/myeloproliferative disorders",
          "myeloproliferative/myelodysplastic disorders",
          "myeloproliferative/myelodysplastic syndromes",
          "MDS/MPN",
          "MPD-MDS",
          "MPD/MDS",
          "myelodysplastic/myeloproliferative neoplasm",
          "myelodysplastic/myeloproliferative neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A category of clonal hematopoietic disorders that have both myelodysplastic and myeloproliferative features at the time of initial presentation."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006311"
    },
    {
      "id": 7955,
      "label": "therapy-related myeloid neoplasm",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000575",
          "GARD:0024414",
          "ICDO:9920/3",
          "NCIT:C27912",
          "ONCOTREE:TMN"
        ],
        "synonyms": [
          "acute myeloid Leukaemias and myelodysplastic syndromes, therapy-related",
          "therapy-related AML and MDS",
          "therapy-related acute myeloid leukaemia and myelodysplastic syndrome",
          "therapy-related acute myeloid leukemia and myelodysplastic syndrome",
          "therapy-related myeloid neoplasm",
          "TMN",
          "therapy-related myeloid neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute myeloid leukemias, myelodysplastic syndromes, and myelodysplastic/myeloproliferative neoplasms arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006450"
    },
    {
      "id": 9364,
      "label": "transient myeloproliferative syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060888",
          "GARD:0012765",
          "HP:0005534",
          "ICDO:9898/1",
          "MEDGEN:331782",
          "MESH:C563551",
          "NCIT:C82339",
          "OMIM:159595",
          "ONCOTREE:TAM",
          "Orphanet:420611",
          "SCTID:721307000",
          "UMLS:C1834582"
        ],
        "synonyms": [
          "MST",
          "TAM",
          "TMD",
          "Transient abnormal myelopoiesis associated with Down syndrome",
          "leukemia, transient, of Down syndrome",
          "transient abnormal myelopoiesis",
          "transient leukaemia",
          "transient leurkemia of Down syndrome",
          "transient myeloproliferative disease",
          "transient myeloproliferative disorder",
          "transient myeloproliferative syndrome",
          "transient myeloproliferative syndrome (disease)",
          "Mst",
          "leukemia, transient",
          "myeloproliferative syndrome, transient"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes spontaneous remission."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008040"
    },
    {
      "id": 10906,
      "label": "primary myelofibrosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16404,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4971",
          "EFO:0002430",
          "GARD:0008618",
          "ICD10CM:D47.4",
          "ICD9:238.76",
          "ICD9:289.83",
          "ICDO:9961/3",
          "MEDGEN:7929",
          "MESH:D055728",
          "NCIT:C2862",
          "NORD:1611",
          "OMIM:254450",
          "ONCOTREE:PMF",
          "Orphanet:824",
          "UMLS:C0001815",
          "icd11.foundation:1407285327",
          "icd11.foundation:336704235"
        ],
        "synonyms": [
          "AMM",
          "Agnogenic myeloid metaplasia",
          "CIMF",
          "chronic idiopathic myelofibrosis",
          "idiopathic bone marrow fibrosis",
          "idiopathic myelofibrosis",
          "myelofibrosis with myeloid metaplasia, somatic",
          "myelofibrosis, somatic",
          "myelosclerosis with myeloid metaplasia",
          "osteomyelofibrosis",
          "primary myelofibrosis",
          "myelofibrosis with myeloid metaplasia",
          "myelofibrosis",
          "myeloid metaplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension."
      },
      "child_count": 8,
      "reference_id": "MONDO:0009692"
    },
    {
      "id": 10909,
      "label": "myeloproliferative disease, autosomal recessive",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024688",
          "MEDGEN:338119",
          "MESH:C564977",
          "OMIM:254700",
          "UMLS:C1850779"
        ],
        "synonyms": [
          "myeloproliferative disease, autosomal recessive"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0009695"
    },
    {
      "id": 15821,
      "label": "thrombocytopenia 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18746,
        19727,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017870",
          "MEDGEN:934756",
          "OMIM:616937",
          "Orphanet:480851",
          "UMLS:C4310789"
        ],
        "synonyms": [
          "hereditary thrombocytopenia with early-onset myelofibrosis",
          "thrombocytopenia 6",
          "thrombocytopenia type 6",
          "THC6",
          "thrombocytopenia, autosomal dominant, 6"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0014837"
    },
    {
      "id": 16452,
      "label": "chronic eosinophilic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3274,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080367",
          "GARD:0020104",
          "ICDO:9964/3",
          "MEDGEN:91106",
          "MESH:C580364",
          "MedDRA:10065854",
          "NCIT:C4563",
          "ONCOTREE:CELNOS",
          "Orphanet:168940",
          "SCTID:188733003",
          "UMLS:C0346421"
        ],
        "synonyms": [
          "CEL",
          "CEL/hypereosinophilic syndrome",
          "chronic eosinophilic leukemia",
          "chronic eosinophilic leukemia/hypereosinophilic syndrome",
          "eosinophilic leukaemia",
          "eosinophilic leukemia",
          "CELNOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0015687"
    },
    {
      "id": 19277,
      "label": "chronic neutrophilic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3274,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080187",
          "EFO:1000179",
          "GARD:0010585",
          "ICDO:9963/3",
          "MEDGEN:6061",
          "MESH:D015467",
          "NCIT:C3179",
          "ONCOTREE:CNL",
          "Orphanet:86829",
          "SCTID:188734009",
          "UMLS:C0023481",
          "icd11.foundation:426734182"
        ],
        "synonyms": [
          "chronic neutrophilic leukemia",
          "neutrophilic leukaemia",
          "neutrophilic leukemia",
          "CNL"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare chronic myeloproliferative neoplasm characterized by neutrophilic leukocytosis. There is no detectable Philadelphia chromosome or BCR/ABL fusion gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019451"
    },
    {
      "id": 19278,
      "label": "myeloproliferative neoplasm, unclassifiable",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016764",
          "ICDO:9975/3",
          "MEDGEN:232365",
          "NCIT:C27350",
          "Orphanet:86830",
          "UMLS:C1333046"
        ],
        "synonyms": [
          "CMPD, U",
          "CMPD-U",
          "MPN, U",
          "MPN-U",
          "chronic myeloproliferative disease, unclassifiable",
          "chronic myeloproliferative disorder, unclassifiable",
          "myeloproliferative neoplasm, unclassifiable",
          "unclassifiable chronic myeloproliferative disease",
          "unclassifiable chronic myeloproliferative disorder",
          "undifferentiated myeloproliferative disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "This subgroup of myeloproliferative neoplasms includes cases which do not meet the morphologic criteria of any of the defined myeloproliferative neoplasms, or which have characteristics that overlap at least two of the myeloproliferative neoplasms."
      },
      "child_count": 1,
      "reference_id": "MONDO:0019452"
    },
    {
      "id": 20110,
      "label": "erythroid neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025216",
          "MEDGEN:272584",
          "NCIT:C7064",
          "UMLS:C1333438"
        ],
        "synonyms": [
          "erythroid neoplasm",
          "erythroid tumor",
          "erythroid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0020703"
    },
    {
      "id": 23472,
      "label": "myelofibrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025920",
          "MEDGEN:10146",
          "NANDO:2100200",
          "NANDO:2200692",
          "NCIT:C3248",
          "UMLS:C0026987"
        ],
        "synonyms": [
          "myelofibrosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma). --2003"
      },
      "child_count": 0,
      "reference_id": "MONDO:0044903"
    }
  ],
  "roots": [
    {
      "id": 6892,
      "label": "myeloid neoplasm"
    },
    {
      "id": 16513,
      "label": "myeloid hemopathy"
    },
    {
      "id": 20376,
      "label": "bone marrow cancer"
    }
  ]
}