{
  "id": 19730,
  "label": "immunodeficiency-associated lymphoproliferative disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020083",
  "properties": {
    "xrefs": [
      "GARD:0019443",
      "MEDGEN:1843142",
      "NCIT:C150672",
      "Orphanet:98290",
      "UMLS:C5681530",
      "icd11.foundation:1678636940"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 16514,
      "label": "lymphoid hemopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020131",
          "MEDGEN:1842533",
          "Orphanet:171898",
          "UMLS:C5680515"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0015757"
    }
  ],
  "children": [
    {
      "id": 19305,
      "label": "methotrexate-associated lymphoproliferative disorders",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6792,
        19730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5821",
          "GARD:0019083",
          "MEDGEN:233702",
          "NCIT:C7184",
          "Orphanet:86904",
          "UMLS:C1334749",
          "icd11.foundation:1520483526"
        ],
        "synonyms": [
          "MTX-LPD",
          "MTX-associated lymphoproliferative disorders",
          "methotrexate-associated lymphoproliferation",
          "methotrexate-associated lymphoproliferative disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Methotrexate-associated lymphoproliferative disorders are rare immunodeficiency-associated lymphoproliferative diseases characterized by lymphoid proliferation or lymphomas (large B-cell lymphoma, T-cell lymphoma, Hodgkin lymphoma, reactive lymphadenitis and a polymorphic post-transplant lymphoproliferative disorder) that develop in patients with different autoimmune diseases treated with methotrexate. Swelling is the predominant manifestation of the disease and regression after methotrexate withdrawal is observed in a significant proportion of patients."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019483"
    },
    {
      "id": 25112,
      "label": "familial hyperinflammatory lymphoproliferative immunodeficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022466",
          "MEDGEN:1842618",
          "Orphanet:619953",
          "UMLS:C5680415"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0850069"
    }
  ],
  "roots": [
    {
      "id": 16514,
      "label": "lymphoid hemopathy"
    }
  ]
}