{
  "id": 19736,
  "label": "autoimmune hemolytic anemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020108",
  "properties": {
    "xrefs": [
      "CSP:0427-1178",
      "DOID:718",
      "EFO:1001264",
      "GARD:0005870",
      "ICD9:283.0",
      "MEDGEN:1918",
      "MESH:D000744",
      "MedDRA:10002046",
      "NANDO:1200305",
      "NANDO:2100181",
      "NCIT:C34378",
      "NORD:774",
      "OMIM:205700",
      "Orphanet:98375",
      "SCTID:413603009",
      "UMLS:C0002880",
      "icd11.foundation:1834341306"
    ],
    "synonyms": [
      "AHA",
      "AIHA",
      "Anemia, Hemolytic, Acquired Autoimmune",
      "autoimmune haemolytic anemia",
      "autoimmune hemolytic anemia",
      "acquired autoimmune hemolytic anaemia",
      "acquired autoimmune hemolytic anemia",
      "anaemia hemolytic autoimmune",
      "anemia hemolytic autoimmune",
      "anemia, autoimmune hemolytic",
      "familial auto-immune hemolytic anaemia (subtype)",
      "familial auto-immune hemolytic anemia (subtype)",
      "idiopathic autoimmune hemolytic anaemia",
      "idiopathic autoimmune hemolytic anemia",
      "immuno-hemolytic anaemia",
      "immuno-hemolytic anemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which various types of auto-antibodies are directed against red blood cells causing their survival to be shortened and resulting in hemolytic anemia."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 3016,
      "label": "autoimmune disorder of blood",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060050"
        ],
        "synonyms": [
          "blood autoimmune disease",
          "blood hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the blood."
      },
      "child_count": 4,
      "reference_id": "MONDO:0000602"
    },
    {
      "id": 5550,
      "label": "hemolytic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5966
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:583",
          "GARD:0023610",
          "ICD10CM:D55-D59",
          "MEDGEN:1916",
          "MESH:D000743",
          "NANDO:2200636",
          "NCIT:C34376",
          "SCTID:61261009",
          "UMLS:C0002878"
        ],
        "synonyms": [
          "anaemia hemolytic",
          "anemia hemolytic",
          "anemia, hemolytic",
          "hemolytic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Anemia resulting from the premature destruction of the peripheral blood red cells. It may be congenital or it may be caused by infections, medications, or malignancies."
      },
      "child_count": 11,
      "reference_id": "MONDO:0003664"
    }
  ],
  "children": [
    {
      "id": 16668,
      "label": "Evans syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        6463,
        18985,
        19736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8931",
          "GARD:0006389",
          "ICD10CM:D69.41",
          "ICD9:287.32",
          "MEDGEN:75773",
          "MESH:C536380",
          "MedDRA:10053873",
          "NANDO:1200310",
          "NCIT:C61284",
          "NORD:1112",
          "Orphanet:1959",
          "SCTID:75331009",
          "UMLS:C0272126",
          "icd11.foundation:1048228553"
        ],
        "synonyms": [
          "Evans' syndrome",
          "autoimmune hemolytic anaemia and autoimmune thrombocytopenia",
          "autoimmune hemolytic anemia and autoimmune thrombocytopenia",
          "immune pancytopenia",
          "Evan syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Evans syndrome is a rare chronic hematologic disorder characterized by the simultaneous or sequential association of autoimmune hemolytic anemia (AIHA; a disorder in which auto-antibodies are directed against red blood cells causing anemia of varying degrees of severity) with immune thrombocytopenic purpura (ITP; a coagulation disorder in which auto-antibodies are directed against platelets causing hemorrhagic episodes) and occasionally autoimmune neutropenia, in the absence of a known underlying etiology."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016030"
    },
    {
      "id": 16961,
      "label": "autoimmune hemolytic anemia, cold type",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020590",
          "MEDGEN:104501",
          "Orphanet:228312",
          "UMLS:C0175816",
          "icd11.foundation:1836938544"
        ],
        "synonyms": [
          "cAHA",
          "cAIHA",
          "cold AIHA"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Cold autoimmune hemolytic anemia comprises two types of autoimmune hemolytic anemia (AIHA) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30B0C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold hemoglobinuria (PCH)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016450"
    },
    {
      "id": 18441,
      "label": "neonatal autoimmune hemolytic anemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18439,
        19736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021645",
          "MEDGEN:1662969",
          "Orphanet:398109",
          "UMLS:C4751517"
        ],
        "synonyms": [
          "neonatal AHA",
          "neonatal AIHA"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018358"
    },
    {
      "id": 19342,
      "label": "autoimmune hemolytic anemia, warm type",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007876",
          "ICD10CM:D59.11",
          "MEDGEN:450541",
          "MedDRA:10047822",
          "NANDO:1200306",
          "NCIT:C162611",
          "NORD:1837",
          "Orphanet:90033",
          "SCTID:3978000",
          "UMLS:C0272118",
          "icd11.foundation:880772122"
        ],
        "synonyms": [
          "Warm Autoimmune Hemolytic Anemia",
          "wAHA",
          "wAIHA",
          "warm AIHA",
          "warm antibody AIHA",
          "warm antibody autoimmune hemolytic anaemia",
          "warm antibody autoimmune hemolytic anemia",
          "warm antibody hemolytic anaemia",
          "warm antibody hemolytic anemia",
          "warm-reacting-antibody hemolytic anaemia",
          "warm-reacting-antibody hemolytic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Warm autoimmune hemolytic anemia is the most common form of autoimmune hemolytic anemia defined by the presence of warm autoantibodies against red blood cells (autoantibodies that are active at temperatures between 37-40B0C)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019532"
    },
    {
      "id": 19344,
      "label": "mixed-type autoimmune hemolytic anemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019101",
          "MEDGEN:930926",
          "NANDO:1200309",
          "Orphanet:90036",
          "SCTID:718716008",
          "UMLS:C4305257",
          "icd11.foundation:1878239449"
        ],
        "synonyms": [
          "mixed AIHA"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Mixed autoimmune hemolytic anemia is a type of autoimmune hemolytic anemia (AIHA) defined by the presence of both warm and cold autoantibodies, which have a deleterious effect on red blood cells at either body temperature or at lower temperatures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019534"
    },
    {
      "id": 19345,
      "label": "drug-induced autoimmune hemolytic anemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019102",
          "ICD10CM:D59.0",
          "MEDGEN:580980",
          "Orphanet:90037",
          "SCTID:309742004",
          "UMLS:C0391817"
        ],
        "synonyms": [
          "drug-induced AIHA"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Drug-induced autoimmune hemolytic anemia is a type of autoimmune hemolytic anemia (AIHA) that occurs as a reaction to therapeutic drugs, and can be due to various mechanisms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019535"
    },
    {
      "id": 29332,
      "label": "giant cell hepatitis with autoimmune hemolytic anemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16828,
        19736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028171"
        ],
        "synonyms": [
          "GCH-AHA",
          "giant cell hepatitis associated with autoimmune hemolytic anemia",
          "giant cell hepatitis with autoimmune haemolytic anaemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare autoimmune disease of early childhood, marked by the simultaneous or sequential immune attack on red blood cells and liver cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:1060166"
    }
  ],
  "roots": [
    {
      "id": 3016,
      "label": "autoimmune disorder of blood"
    },
    {
      "id": 5550,
      "label": "hemolytic anemia"
    }
  ]
}