{
  "id": 19739,
  "label": "primary acquired red cell aplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020113",
  "properties": {
    "xrefs": [
      "GARD:0019465",
      "MedDRA:10038184",
      "Orphanet:98421"
    ],
    "synonyms": [
      "red cell aplasia",
      "primary autoimmune red cell aplasia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 16404,
      "label": "acquired aplastic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16610
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020058",
          "MEDGEN:543648",
          "NANDO:2201277",
          "Orphanet:164823",
          "SCTID:55907008",
          "UMLS:C0271907"
        ],
        "synonyms": [
          "acquired aplastic anemia",
          "rare acquired aplastic anaemia",
          "rare acquired aplastic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An instance of aplastic anemia that is acquired during the lifetime of the individual."
      },
      "child_count": 3,
      "reference_id": "MONDO:0015610"
    }
  ],
  "children": [
    {
      "id": 10440,
      "label": "transient erythroblastopenia of childhood",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19739
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007793",
          "ICD9:284.81",
          "MEDGEN:68670",
          "MESH:C536980",
          "NCIT:C131683",
          "OMIM:227050",
          "Orphanet:98871",
          "SCTID:191255003",
          "UMLS:C0238478"
        ],
        "synonyms": [
          "transient acquired pure red cell aplasia",
          "transient erythroblastopenia of childhood",
          "erythroblastopenia, transient",
          "familial transient erythroblastopenia of childhood",
          "tec"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acquired pure red cell aplasia that is self-limited. It is the most common cause of decreased red blood cell production in the pediatric population, and typically presents as a normocytic anemia with reticulocytopenia in an otherwise asymptomatic and normal child with no evidence of other causes for anemia, including blood loss, hemolysis, nutritional deficiency, or malignancy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009197"
    },
    {
      "id": 19806,
      "label": "adult pure red cell aplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3893,
        19739
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010898",
          "MEDGEN:1647585",
          "NANDO:1200889",
          "NANDO:2200613",
          "NCIT:C70548",
          "Orphanet:98872",
          "SCTID:765748009",
          "UMLS:C4707560",
          "icd11.foundation:45753120"
        ],
        "synonyms": [
          "adult pure red-cell aplasia",
          "pure red-cell aplasia of adults",
          "acquired PRCA",
          "acquired pure red cell aplasia",
          "idiopathic pure red cell aplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Adult pure red cell aplasia is a rare acquired aplastic anemia characterized by a severe normocytic anemia with normal peripheral leukocyte and platelet counts, reticulocytopenia, high serum ferritin and transferrin saturation levels and isolated, almost complete absence of erythroblasts in the bone marrow with normal granulopoesis and megakaryopoesis. It presents with signs of severe anemia (fatigue, lethargy, pallor, intolerance of physical exercise and exertional dyspnea) in the absence of hemorrhagic symptoms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020338"
    }
  ],
  "roots": [
    {
      "id": 16404,
      "label": "acquired aplastic anemia"
    }
  ]
}