{
  "id": 19745,
  "label": "acquired idiopathic inflammatory myopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020122",
  "properties": {
    "xrefs": [
      "GARD:0009128",
      "ICD9:359.79",
      "Orphanet:98482",
      "icd11.foundation:464294586"
    ],
    "synonyms": [
      "IIm",
      "IMM",
      "idiopathic inflammatory myopathies",
      "idiopathic inflammatory myositis",
      "idiopathic inflammatory myopathy, familial"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "An umbrella term for diseases which have chronic muscle inflammation and weakness of unknown etiology. The types of idiopathic inflammatory myopathy are further defined by either clinicopathologic criteria or by the presence of certain autoantibodies."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 16731,
      "label": "acquired skeletal muscle disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19743
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842576",
          "Orphanet:206638",
          "UMLS:C5680799"
        ],
        "synonyms": [
          "acquired skeletal muscle disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An instance of skeletal muscle disease that is acquired during the lifetime of the individual."
      },
      "child_count": 5,
      "reference_id": "MONDO:0016105"
    },
    {
      "id": 24391,
      "label": "idiopathic inflammatory myopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20400
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026301",
          "MEDGEN:148290",
          "NCIT:C116796",
          "SCTID:702380008",
          "UMLS:C0751356"
        ],
        "synonyms": [
          "idiopathic myositis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Idiopathic form of inflammatory myopathy."
      },
      "child_count": 2,
      "reference_id": "MONDO:0600023"
    },
    {
      "id": 24405,
      "label": "idiopathic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29381
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:548250",
          "UMLS:C0277553"
        ],
        "synonyms": [
          "idiopathic disorder"
        ],
        "definition": "A disease or disorder for which the cause is of uncertain or unknown."
      },
      "child_count": 79,
      "reference_id": "MONDO:0700007"
    }
  ],
  "children": [
    {
      "id": 10418,
      "label": "eosinophilic fasciitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6588,
        19745
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006351",
          "HP:0045029",
          "ICD9:728.89",
          "MEDGEN:82673",
          "MESH:C562487",
          "MedDRA:10014954",
          "NCIT:C112116",
          "OMIM:226350",
          "Orphanet:3165",
          "SCTID:24129002",
          "UMLS:C0264005",
          "icd11.foundation:1977389237"
        ],
        "synonyms": [
          "Shulman syndrome",
          "diffuse fasciitis with eosinophilia",
          "eosinophilic fasciitis",
          "eosinophilic fasciitis (disease)",
          "EF"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Eosinophilic fasciitis is a rare connective tissue disease that is characterized by inflammation and thickening of the fascia, usually associated with peripheral eosinophilia. It presents during adulthood with symmetrical and painful swelling of mainly the extremities that progressively become indurated. Fatigue, disabling cutaneous fibrosis, myositis and arthritis may also be observed."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009175"
    },
    {
      "id": 16725,
      "label": "immune-mediated necrotizing myopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19745
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020351",
          "MEDGEN:899492",
          "Orphanet:206569",
          "SCTID:715863001",
          "UMLS:C3267047"
        ],
        "synonyms": [
          "IMNM",
          "NAM",
          "anti-HMG-CoA myopathy",
          "anti-SRP myopathy",
          "autoimmune necrotizing myositis",
          "immune myopathy with myocyte necrosis",
          "necrotizing autoimmune myopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Necrotizing autoimmune myopathy (NAM) is a rare form of idiopathic inflammatory myopathy characterized clinically by acute or subacute proximal muscle weakness, and histopathologically by myocyte necrosis and regeneration without significant inflammation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016098"
    },
    {
      "id": 16726,
      "label": "overlap myositis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19745
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020352",
          "MEDGEN:1814440",
          "Orphanet:206572",
          "UMLS:C5679784"
        ],
        "synonyms": [
          "adult-onset overlap myositis",
          "non-specific myositis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Overlap myositis (OM) is a form of idiopathic inflammatory myopathy (IIM) characterized by myositis with at least one clinical and/or autoantibody overlap feature."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016099"
    },
    {
      "id": 17093,
      "label": "inflammatory myopathy with abundant macrophages",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19745
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020663",
          "MEDGEN:1638939",
          "Orphanet:247718",
          "SCTID:766706007",
          "UMLS:C4707791"
        ],
        "synonyms": [
          "IMAM",
          "imam"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Inflammatory myopathy with abundant macrophages is a rare inflammatory myopathy characterized by diffuse destructive infiltration of CD68+ macrophages into the fascia rather than muscle fibers in muscle biopsies, proximal muscle weakness and myalgia with or without scaly dermatomyositis-like or atypical non-dermatomyositis-like skin lesions, elevation of creatine kinase levels and thickening of muscle fascia in muscle MRI."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016609"
    },
    {
      "id": 17094,
      "label": "idiopathic eosinophilic myositis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19745
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020664",
          "MEDGEN:1659844",
          "Orphanet:247724",
          "UMLS:C4755301"
        ],
        "synonyms": [
          "idiopathic eosinophilia-associated myopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016610"
    },
    {
      "id": 18185,
      "label": "juvenile idiopathic inflammatory myopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19745
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021496",
          "MEDGEN:1842624",
          "Orphanet:329888",
          "UMLS:C5679857"
        ],
        "synonyms": [
          "JIIM"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0018010"
    },
    {
      "id": 18781,
      "label": "focal myositis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19745
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018837",
          "ICD9:729.1",
          "MEDGEN:592748",
          "Orphanet:48918",
          "SCTID:240119009",
          "UMLS:C0409988",
          "icd11.foundation:708931518"
        ],
        "synonyms": [
          "focal nodular myositis",
          "inflammatory pseudotumor of skeletal muscle"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Focal myositis is a rare inflammatory myopathy characterized by a localized swelling of skeletal muscle that is usually located in the lower extremities."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018845"
    },
    {
      "id": 19007,
      "label": "polymyositis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19745
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080745",
          "EFO:0003063",
          "GARD:0007425",
          "ICD10CM:M33.2",
          "ICD9:710.4",
          "MEDGEN:39086",
          "MESH:D017285",
          "MedDRA:10036102",
          "NANDO:1200276",
          "NCIT:C26925",
          "Orphanet:732",
          "SCTID:31384009",
          "UMLS:C0085655",
          "Wikipedia:Polymyositis",
          "icd11.foundation:1157134196"
        ],
        "synonyms": [
          "PM",
          "polymyositis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A rare idiopathic inflammatory myopathy characterized by symmetric proximal muscle weakness and elevated muscle enzymes."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019127"
    },
    {
      "id": 19182,
      "label": "antisynthetase syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19745
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080744",
          "EFO:1001982",
          "GARD:0000735",
          "ICD9:279.49",
          "MEDGEN:1866768",
          "MESH:C537778",
          "MedDRA:10068801",
          "NORD:1926",
          "Orphanet:81",
          "SCTID:445187004",
          "UMLS:C5959873",
          "icd11.foundation:1572057936"
        ],
        "synonyms": [
          "AS syndrome",
          "anti-Jo1 syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Antisynthetase (AS) syndrome is a clinically heterogeneous form of idiopathic inflammatory myopathy characterized by myositis, arthralgia, Raynaud phenomenon, mechanic hands, interstitial lung disease (ILD), and serum autoantibodies to aminoacyl transfer RNA synthetases (anti-ARS)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019344"
    }
  ],
  "roots": [
    {
      "id": 16731,
      "label": "acquired skeletal muscle disease"
    },
    {
      "id": 24391,
      "label": "idiopathic inflammatory myopathy"
    },
    {
      "id": 24405,
      "label": "idiopathic disease"
    }
  ]
}