{
  "id": 19749,
  "label": "motor neuron disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020128",
  "properties": {
    "xrefs": [
      "DOID:231",
      "EFO:0003782",
      "GARD:0019477",
      "ICD10CM:G12.2",
      "ICD9:335.2",
      "ICD9:335.8",
      "ICD9:335.9",
      "MEDGEN:38785",
      "MESH:D016472",
      "MedDRA:10028003",
      "Orphanet:98503",
      "SCTID:37340000",
      "UMLS:C0085084",
      "icd11.foundation:661720689"
    ],
    "synonyms": [
      "anterior horn cell disease",
      "disease of motor neuron",
      "disease or disorder of motor neuron",
      "disorder of motor neuron",
      "motor neuron disease",
      "motor neuron disease or disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Neurological disease involving the motor neuron."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7208,
      "label": "neurodegenerative disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1289",
          "EFO:0005772",
          "ICD9:349.89",
          "MEDGEN:17999",
          "MESH:D019636",
          "NCIT:C4802",
          "SCTID:80690008",
          "UMLS:C0027746"
        ],
        "synonyms": [
          "degenerative disease",
          "brain degeneration",
          "central nervous system degenerative disorder",
          "central nervous system neurodegenerative disorder",
          "degenerative disorder of central nervous system",
          "cerebral degeneration disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005559"
    },
    {
      "id": 18957,
      "label": "neuromuscular disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:440",
          "EFO:1001902",
          "ICD9:358",
          "ICD9:358.9",
          "MEDGEN:10323",
          "MESH:D009468",
          "MedDRA:10029323",
          "NANDO:1100001",
          "NANDO:2100214",
          "Orphanet:68381",
          "UMLS:C0027868"
        ],
        "synonyms": [
          "nerve and muscle disorder",
          "neuromuscular disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any disease that impairs the functioning of the muscles, either directly, being pathologies of the voluntary muscle, or indirectly, being pathologies of nerves or neuromuscular junctions"
      },
      "child_count": 8,
      "reference_id": "MONDO:0019056"
    }
  ],
  "children": [
    {
      "id": 6718,
      "label": "amyotrophic lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5143,
        19749
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:332",
          "GARD:0005786",
          "HP:0007354",
          "ICD10CM:G12.21",
          "ICD9:335.20",
          "MEDGEN:274",
          "MESH:D000690",
          "MedDRA:10002026",
          "NANDO:1200002",
          "NCIT:C34373",
          "NORD:768",
          "Orphanet:803",
          "SCTID:86044005",
          "UMLS:C0002736",
          "birnlex:12566",
          "icd11.foundation:1982355687"
        ],
        "synonyms": [
          "ALS",
          "Charcot disease",
          "Lou Gehrig disease",
          "amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004976"
    },
    {
      "id": 16186,
      "label": "Madras motor neuron disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19749
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019887",
          "MEDGEN:581442",
          "Orphanet:137867",
          "UMLS:C0393551",
          "icd11.foundation:1764644031"
        ],
        "synonyms": [
          "MMND"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Madras motor neuron disease (MMND) is characterized by weakness and atrophy of limbs, multiple lower cranial nerve palsies and sensorineural hearing loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015307"
    },
    {
      "id": 19750,
      "label": "acquired motor neuron disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19749
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019479",
          "MEDGEN:1842733",
          "Orphanet:98506",
          "UMLS:C5680367"
        ],
        "synonyms": [
          "acquired anterior horn cell disease",
          "acquired motor neuron disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of motor neuron disease that is acquired during the lifetime of the individual."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020129"
    },
    {
      "id": 21302,
      "label": "hereditary motor neuron disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19749,
        21292,
        24271
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019478",
          "MEDGEN:78728",
          "Orphanet:98505",
          "SCTID:49793008",
          "UMLS:C0270763"
        ],
        "synonyms": [
          "genetic anterior horn cell disease",
          "genetic motor neuron disease",
          "hereditary motor neuron disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of motor neuron disease that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 27,
      "reference_id": "MONDO:0024257"
    }
  ],
  "roots": [
    {
      "id": 7208,
      "label": "neurodegenerative disease"
    },
    {
      "id": 18957,
      "label": "neuromuscular disease"
    }
  ]
}