{
  "id": 19774,
  "label": "congenital tricuspid malformation",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020289",
  "properties": {
    "xrefs": [
      "GARD:0019555",
      "HP:0001702",
      "MEDGEN:1842501",
      "Orphanet:98721",
      "UMLS:C5681691"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 2932,
      "label": "tricuspid valve disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4883
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050826",
          "EFO:0009568",
          "ICD9:397.0",
          "MEDGEN:120507",
          "NCIT:C78649",
          "SCTID:20721001",
          "UMLS:C0264882",
          "icd11.foundation:1843615838"
        ],
        "synonyms": [
          "disease of tricuspid valve",
          "disease or disorder of tricuspid valve",
          "disorder of tricuspid valve",
          "tricuspid valve disease",
          "tricuspid valve disease or disorder",
          "tricuspid valve disorder",
          "RH. tricuspid valve disease",
          "rheumatic disease of tricuspid valve",
          "rheumatic tricuspid valve disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease involving the tricuspid valve."
      },
      "child_count": 4,
      "reference_id": "MONDO:0000471"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:Q00-Q99",
          "MEDGEN:1843482",
          "UMLS:C0694457"
        ],
        "definition": "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021147"
    }
  ],
  "children": [
    {
      "id": 8424,
      "label": "tricuspid valve prolapse",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7210,
        19774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5644",
          "EFO:1001218",
          "HP:0001704",
          "MEDGEN:11912",
          "MESH:D014263",
          "MedDRA:10066862",
          "Orphanet:95458",
          "SCTID:253383003",
          "UMLS:C0040962",
          "icd11.foundation:973833808"
        ],
        "synonyms": [
          "tricuspid valve prolapse",
          "tricuspid valve prolapse (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Abnormal protrusion of one or more of the leaflets of tricuspid valve into the right atrium during systole. This allows the backflow of blood into right atrium leading to tricuspid valve insufficiency; systolic murmurs. Its most common cause is not primary valve abnormality but rather the dilation of the right ventricle and the tricuspid annulus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007001"
    },
    {
      "id": 10388,
      "label": "Ebstein anomaly",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14289",
          "EFO:0007244",
          "GARD:0006313",
          "ICD10CM:Q22.5",
          "ICD9:746.2",
          "MEDGEN:4435",
          "MESH:D004437",
          "MedDRA:10014075",
          "NANDO:1200711",
          "NANDO:2100080",
          "NANDO:2200260",
          "NCIT:C84681",
          "OMIM:224700",
          "Orphanet:1880",
          "UMLS:C0013481",
          "icd11.foundation:307157712"
        ],
        "synonyms": [
          "Ebstein anomaly",
          "Ebstein anomaly (disease)",
          "Ebstein anomaly of the tricuspid valve",
          "Ebstein's anomaly",
          "Ebstein's anomaly (disorder) [ambiguous]",
          "Ebstein's anomaly of tricuspid valve",
          "Ebstein malformation",
          "Ebstein's malformation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Ebstein's malformation is a rare congenital cardiac anomaly characterized by rotational displacement of the septal and inferior leaflets of the tricuspid valve such that they are hinged within the right ventricle, rather than as expected at the atrioventricular junction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009144"
    },
    {
      "id": 11893,
      "label": "cardiac valvular dysplasia, X-linked",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19774,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111765",
          "GARD:0001096",
          "MEDGEN:78083",
          "MESH:C535576",
          "OMIM:314400",
          "Orphanet:1864",
          "Orphanet:555877",
          "SCTID:718128009",
          "UMLS:C0262436"
        ],
        "synonyms": [
          "CVD1",
          "XMVD",
          "cardiac valvular dysplasia, X-linked",
          "congenital valvular dysplasia",
          "myxomatous valvular dystrophy, X-linked",
          "valvular heart disease, congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010753"
    },
    {
      "id": 12614,
      "label": "tricuspid atresia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7116,
        19774,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080169",
          "GARD:0005274",
          "HP:0011662",
          "MEDGEN:67034",
          "MESH:D018785",
          "MedDRA:10049767",
          "NANDO:1200706",
          "NANDO:1200962",
          "NANDO:2100073",
          "NANDO:2200251",
          "NCIT:C85202",
          "OMIM:605067",
          "Orphanet:1209",
          "SCTID:63042009",
          "UMLS:C0243002",
          "icd11.foundation:845891723"
        ],
        "synonyms": [
          "congenital atresia of tricuspid valve",
          "tricuspid atresia",
          "tricuspid atresia (disease)",
          "tricuspid valve atresia",
          "congenital agenesis of the tricuspid valve"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Tricuspid atresia is (TA) a rare congenital heart malformation characterized by the congenital agenesis of tricuspid valve leading to severe hypoplasia of right ventricle (functionally univentricular). TA is associated with normally related or transposed great vessels (TGV), an obligatory interatrial connection that is crucial for survival (patent foramen ovale or atrial septal defect, osteum secondum type), ventricular septal defect (in 90% cases), pulmonary outflow obstruction - pulmonary atresia, stenosis or hypoplasia (usually in TA with normally related vessels but also in TGV), aortic coarctation and/or aortic arch interruption (usually in TA with TGV)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011514"
    },
    {
      "id": 19552,
      "label": "tricuspid valve agenesis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019261",
          "MEDGEN:672653",
          "Orphanet:95457",
          "UMLS:C0685715"
        ],
        "synonyms": [
          "congenital unguarded tricuspid orifice"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019811"
    },
    {
      "id": 19553,
      "label": "congenital tricuspid stenosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019262",
          "ICD10CM:Q22.4",
          "MEDGEN:539527",
          "MedDRA:10010656",
          "NANDO:1200962",
          "Orphanet:95459",
          "SCTID:36233006",
          "UMLS:C0265836",
          "icd11.foundation:1996822362"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019813"
    },
    {
      "id": 19554,
      "label": "straddling or overriding tricuspid valve",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019263",
          "MEDGEN:1818564",
          "Orphanet:95461",
          "UMLS:C5761644"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Straddling or overriding tricuspid valve is a rare, congenital, tricuspid valve malformation characterized by the tricuspid valve that overrides the ventricular septum and communicates with both ventricles, as part of the tension apparatus of the valve crosses the ventricular septal defect and is attached in the left ventricle. The anomaly occurs with other congenital heart defects (transposition of great vessels, left ventricle outflow tract obstruction, double outlet right ventricle, hypoplastic right ventricle), which determine the main clinical manifestation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019814"
    },
    {
      "id": 19555,
      "label": "accessory tricuspid valve tissue",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019264",
          "MEDGEN:1798036",
          "Orphanet:95462",
          "UMLS:C5566613"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Accessory tricuspid valve tissue is a rare, congenital, atrioventricular valve malformation characterized by fixed or mobile accessory tissue on the tricuspid valve, usually associated with other complex congenital heart anomalies (atrial septal defect, ventricular septal defect, transposition of great arteries, tetralogy Fallot). It may present clinically with systolic murmur, dyspnea, cyanosis, depending also on accompanying congenital heart anomaly."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019815"
    },
    {
      "id": 19855,
      "label": "anomaly of the tricuspid valve chordae",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019623",
          "MEDGEN:757566",
          "Orphanet:99055",
          "UMLS:C3165162"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Anomaly of the tricuspid valve chordae is a rare, congenital anomaly of the tricuspid subvalvular apparatus characterized by aberrant tendinous chords, which insert at the clear zone of the leaflet instead of its free edge and connect to the endocardium instead of the papillary muscles. Resulting tethering of one or more tricuspid leaflets leads to their impaired mobility and tricuspid regurgitation. Association with other congenital cardiac anomalies has been reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020396"
    },
    {
      "id": 19856,
      "label": "parachute tricuspid valve",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019624",
          "MEDGEN:576478",
          "Orphanet:99056",
          "UMLS:C0344755"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Parachute tricuspid valve is a rare congenital heart malformation defined as an insertion of the chordal apparatus into a single papillary muscle or a muscle group, making a pathognomonic 'pear' shape sign in the four-chamber echocardiographic view with the atrium forming the larger base of the pear and the leaflets the apex. Isolated parachute tricuspid valve may be asymptomatic or present with symptoms of tricuspid stenosis (diastolic inspiratory murmur, pulsation of jugular veins, hepatomegaly, edema, epigastric discomfort, right atrial enlargement, right ventricular hypertrophy, electrocardiography abnormalities). It may also be associated with other heart malformations and present with symptoms of the complex of malformations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020397"
    }
  ],
  "roots": [
    {
      "id": 2932,
      "label": "tricuspid valve disorder"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis"
    }
  ]
}