{
  "id": 19796,
  "label": "primary mediastinal large B-cell lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020323",
  "properties": {
    "xrefs": [
      "DOID:0080210",
      "GARD:0019589",
      "ICD10CM:C85.2",
      "ICDO:9679/3",
      "MEDGEN:714984",
      "MedDRA:10036710",
      "NCIT:C9280",
      "ONCOTREE:PMBL",
      "Orphanet:98838",
      "SCTID:444910004",
      "UMLS:C1292754",
      "icd11.foundation:950282079"
    ],
    "synonyms": [
      "B-cell diffuse large cell lymphoma of mediastinum",
      "B-cell diffuse large cell lymphoma of the mediastinum",
      "Med-DLBCL",
      "PMBL",
      "PMLCL",
      "large cell lymphoma of the mediastinum",
      "mediastinal (thymic) large B-cell lymphoma",
      "mediastinal B-cell diffuse large cell lymphoma",
      "mediastinal diffuse large cell lymphoma with sclerosis",
      "mediastinal diffuse large-cell lymphoma with sclerosis",
      "mediastinal large B-cell lymphoma",
      "primary mediastinal clear cell lymphoma of B-cell type",
      "primary mediastinal large B-cell lymphoma",
      "primary mediastinal (thymic) large B-cell lymphoma",
      "primary mediastinal B-cell lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically it is characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis. Response to intensive chemotherapy, with or without radiotherapy, is usually good. (WHO, 2001)"
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3220,
      "label": "thymus lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4646,
        5869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10146",
          "EFO:1000054",
          "GARD:0022852",
          "MEDGEN:277818",
          "NCIT:C6451",
          "UMLS:C1336745"
        ],
        "synonyms": [
          "Thymus lymphoma",
          "lymphoma of Thymus",
          "lymphoma of the Thymus",
          "lymphoma of thymus",
          "primary thymic lymphoma",
          "thymic lymphoma",
          "thymus lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A lymphoma that arises from the thymus. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000951"
    },
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050745",
          "EFO:0000403",
          "GARD:0003178",
          "ICD10CM:C83.3",
          "ICD9:200.7",
          "ICDO:9680/3",
          "MEDGEN:86954",
          "MESH:D016403",
          "MedDRA:10012818",
          "NCIT:C8851",
          "Orphanet:544",
          "UMLS:C0079744",
          "icd11.foundation:1946973604"
        ],
        "synonyms": [
          "DLBCL",
          "diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common."
      },
      "child_count": 60,
      "reference_id": "MONDO:0018905"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3220,
      "label": "thymus lymphoma"
    },
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma"
    }
  ]
}