{
  "id": 19798,
  "label": "anaplastic large cell lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020325",
  "properties": {
    "xrefs": [
      "DOID:0050744",
      "EFO:0003032",
      "GARD:0003112",
      "HGNC:427",
      "ICD9:200.6",
      "ICD9:200.60",
      "ICDO:9714/3",
      "MEDGEN:61533",
      "MESH:D017728",
      "NANDO:2200021",
      "NCIT:C3720",
      "ONCOTREE:ALCL",
      "Orphanet:98841",
      "SCTID:277637000",
      "UMLS:C0206180"
    ],
    "synonyms": [
      "ALCL",
      "CD30 Positive anaplastic large cell lymphoma",
      "CD30 positive anaplastic large cell lymphoma",
      "Ki-1 lymphoma",
      "Ki-1 positive anaplastic large cell lymphoma",
      "Ki-1+ ALCL",
      "Ki-1+ anaplastic large cell lymphoma",
      "anaplastic large cell lymphoma",
      "primary systemic ALCL",
      "sACL"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Anaplastic large cell lymphoma (ALCL) is a rare and aggressive peripheral T-cell non-Hodgkin lymphoma, belonging to the group of CD30-positive lymphoproliferative disorders, which affects lymph nodes and extranodal sites. It is comprised of two sub-types, based on the expression of a protein called anaplastic lymphoma kinase (ALK): ALK positive and ALK negative ALCL."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6891,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050743",
          "DOID:0050749",
          "GARD:0007368",
          "ICD10CM:C84.4",
          "ICDO:9702/3",
          "MEDGEN:1790498",
          "MESH:D016411",
          "NCIT:C3468",
          "SCTID:109977009",
          "UMLS:C5551485"
        ],
        "synonyms": [
          "PTCL",
          "mature T-and NK-cell lymphoma",
          "mature T-cell and NK-cell lymphoma",
          "mature T-cell and NK-cell non-Hodgkin lymphoma",
          "mature T-cell and NK-cell non-Hodgkin's lymphoma",
          "mature T-cell lymphoma",
          "mature T-cell non-Hodgkin's lymphoma",
          "peripheral T-cell lymphoma",
          "NK-T cell lymphoma",
          "mature T-cell and natural killer cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature T- and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000430"
    }
  ],
  "children": [
    {
      "id": 7693,
      "label": "central nervous system anaplastic large cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19798,
        20048,
        23470
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000156",
          "GARD:0024302",
          "MEDGEN:235493",
          "NCIT:C5322",
          "UMLS:C1335476"
        ],
        "synonyms": [
          "anaplastic CNS large cell lymphoma",
          "anaplastic central nervous system large cell lymphoma",
          "anaplastic large cell lymphoma of CNS",
          "anaplastic large cell lymphoma of central nervous system",
          "anaplastic large cell lymphoma of the CNS",
          "anaplastic large cell lymphoma of the central nervous system",
          "central nervous system anaplastic large cell lymphoma",
          "primary CNS anaplastic large cell lymphoma",
          "primary central nervous system anaplastic large cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An anaplastic large cell lymphoma that affects the brain, meninges, or spinal cord."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006128"
    },
    {
      "id": 17878,
      "label": "primary cutaneous anaplastic large cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3019,
        18825,
        19798,
        20048
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021247",
          "MEDGEN:266255",
          "MESH:D054446",
          "MedDRA:10065863",
          "NCIT:C6860",
          "ONCOTREE:PCALCL",
          "Orphanet:300865",
          "UMLS:C1301362",
          "icd11.foundation:1972636482"
        ],
        "synonyms": [
          "ALCL, cutaneous",
          "C-ALCL",
          "anaplastic large-cell lymphoma, primary cutaneous type",
          "primary C-ALCL",
          "primary anaplastic large cell lymphoma of skin",
          "primary anaplastic large cell lymphoma of the skin",
          "primary cutaneous CD30 Positive anaplastic large cell lymphoma",
          "primary cutaneous CD30+ ALCL",
          "primary cutaneous CD30+ anaplastic large cell lymphoma",
          "regressive atypical histiocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is a rare T-cell non-Hodgkin lymphoma that affects the skin and generally shows no extracutaneous involvement at presentation. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders along with lymphomatoid papulosis with which it shares overlapping clinical and histopathologic features."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017598"
    },
    {
      "id": 17882,
      "label": "ALK-positive anaplastic large cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021251",
          "ICD10CM:C84.6",
          "ICDO:9714/3",
          "MEDGEN:233117",
          "NCIT:C37193",
          "Orphanet:300895",
          "UMLS:C1332079"
        ],
        "synonyms": [
          "ALCL, ALK+",
          "ALK+ ALCL",
          "ALK+ anaplastic large cell lymphoma",
          "ALK-positive anaplastic large cell lymphoma",
          "ALKoma",
          "anaplastic large cell lymphoma, ALK-positive"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) is a type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017602"
    },
    {
      "id": 17883,
      "label": "ALK-negative anaplastic large cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000083",
          "GARD:0021252",
          "ICD10CM:C84.7",
          "ICDO:9702/3",
          "MEDGEN:272266",
          "NCIT:C37194",
          "Orphanet:300903",
          "UMLS:C1332078"
        ],
        "synonyms": [
          "ALCL, ALK-",
          "ALK- ALCL",
          "ALK- anaplastic large cell lymphoma",
          "ALK-negative anaplastic large cell lymphoma",
          "anaplastic large cell lymphoma, ALK-negative"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "ALK-negative anaplastic large cell lymphoma (ALK- ALCL) is a type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the lack of expression of a protein called anaplastic lymphoma kinase (ALK)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017603"
    },
    {
      "id": 20769,
      "label": "small cell variant anaplastic large cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009477",
          "MEDGEN:234787",
          "MESH:C538255",
          "NCIT:C7208",
          "UMLS:C1335983"
        ],
        "synonyms": [
          "small cell variant anaplastic large cell lymphoma",
          "small cell variant of anaplastic large cell lymphoma",
          "anaplastic small cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A histologic variant of anaplastic large cell lymphoma characterized by the presence of a predominant population of small to medium size malignant cells with irregular nuclei."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021879"
    }
  ],
  "roots": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma"
    }
  ]
}