{
  "id": 19800,
  "label": "indolent systemic mastocytosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020331",
  "properties": {
    "xrefs": [
      "DOID:4660",
      "GARD:0019595",
      "ICDO:9741/1",
      "MEDGEN:82897",
      "MedDRA:10056452",
      "NCIT:C9286",
      "ONCOTREE:ISM",
      "Orphanet:98848",
      "SCTID:70910003",
      "UMLS:C0272203",
      "icd11.foundation:353283231"
    ],
    "synonyms": [
      "ISM",
      "indolent systemic mastocytosis (morphologic abnormality)",
      "ism"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Indolent systemic mastocytosis (ISM) is a benign form of systemic mastocytosis (SM) characterized by an abnormal proliferation of mast cells either only in bone marrow or in numerous tissues."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 17076,
      "label": "systemic mastocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9280
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:349",
          "GARD:0008616",
          "ICD10CM:D47.02",
          "MEDGEN:67436",
          "MedDRA:10042949",
          "NCIT:C9235",
          "ONCOTREE:SM",
          "Orphanet:2467",
          "SCTID:397016004",
          "UMLS:C0221013",
          "icd11.foundation:1144812971"
        ],
        "synonyms": [
          "Mast cell disease",
          "systemic mastocytosis",
          "systemic tissue Mast cell disease",
          "systemic tissue mast cell disease",
          "Aggressive systemic mastocytosis",
          "SM",
          "systemic mast cell disease",
          "systemic mastocytosis with associated hemotologic non-mast cell lineage disease (SM-AHNMD)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Systemic mastocytosis (SM) comprises a heterogeneous group of rare acquired and chronic hematological malignancies that are related to an abnormal proliferation of mast cells in tissue, including bone marrow, with or without skin involvement."
      },
      "child_count": 5,
      "reference_id": "MONDO:0016586"
    }
  ],
  "children": [
    {
      "id": 16368,
      "label": "Smouldering systemic mastocytosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19800
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020036",
          "MEDGEN:856636",
          "NCIT:C115460",
          "Orphanet:158775",
          "UMLS:C3897042",
          "icd11.foundation:481663898"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Smouldering systemic mastocytosis is a type of systemic mastocytosis (SM). This clonal hematologic disease, with a slow progression, results in an accumulation of neoplastic mast cells in the visceral organs over time and patients present with splenomegaly, hypercellular marrow and, in some cases, urticaria pigmentosa-like skin lesions."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015557"
    },
    {
      "id": 16369,
      "label": "isolated bone marrow mastocytosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19800
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020037",
          "MEDGEN:1672479",
          "NCIT:C198573",
          "Orphanet:158778",
          "UMLS:C4509020",
          "icd11.foundation:922733413"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0015558"
    }
  ],
  "roots": [
    {
      "id": 17076,
      "label": "systemic mastocytosis"
    }
  ]
}