{
  "id": 19803,
  "label": "mast cell leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020334",
  "properties": {
    "xrefs": [
      "DOID:9254",
      "EFO:0007359",
      "GARD:0019598",
      "ICDO:9742/3",
      "MEDGEN:44123",
      "MESH:D007946",
      "MedDRA:10056450",
      "NCIT:C3169",
      "ONCOTREE:SMMCL",
      "Orphanet:158799",
      "Orphanet:98851",
      "SCTID:110002002",
      "UMLS:C0023461",
      "icd11.foundation:1359806843"
    ],
    "synonyms": [
      "Mast cell leukaemia",
      "Mast cell leukemia",
      "aleukemic mast cell leukaemia",
      "aleukemic mast cell leukemia",
      "mast-cell leukaemia",
      "mast-cell leukemia",
      "SMMCL"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Mast cell leukemia is a malignant form of systemic mastocytosis (SM) characterized, most of the time, by the presence of circulating mast cells."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6789,
      "label": "leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1240",
          "EFO:0000565",
          "HP:0001909",
          "ICD9:207",
          "ICD9:207.8",
          "ICD9:207.80",
          "ICD9:208",
          "ICD9:208.8",
          "ICD9:208.80",
          "ICD9:208.9",
          "ICD9:208.90",
          "ICDO:9800/3",
          "MEDGEN:9725",
          "MESH:D007938",
          "NANDO:2100002",
          "NCIT:C3161",
          "SCTID:93143009",
          "UMLS:C0023418"
        ],
        "synonyms": [
          "blood (leukemia)",
          "leukaemia (disease)",
          "leukemia",
          "leukemia (disease)",
          "leukemia, disease",
          "leukemia, malignant",
          "leukemias",
          "leukemias, general",
          "leukaemia NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005059"
    },
    {
      "id": 17076,
      "label": "systemic mastocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9280
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:349",
          "GARD:0008616",
          "ICD10CM:D47.02",
          "MEDGEN:67436",
          "MedDRA:10042949",
          "NCIT:C9235",
          "ONCOTREE:SM",
          "Orphanet:2467",
          "SCTID:397016004",
          "UMLS:C0221013",
          "icd11.foundation:1144812971"
        ],
        "synonyms": [
          "Mast cell disease",
          "systemic mastocytosis",
          "systemic tissue Mast cell disease",
          "systemic tissue mast cell disease",
          "Aggressive systemic mastocytosis",
          "SM",
          "systemic mast cell disease",
          "systemic mastocytosis with associated hemotologic non-mast cell lineage disease (SM-AHNMD)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Systemic mastocytosis (SM) comprises a heterogeneous group of rare acquired and chronic hematological malignancies that are related to an abnormal proliferation of mast cells in tissue, including bone marrow, with or without skin involvement."
      },
      "child_count": 5,
      "reference_id": "MONDO:0016586"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6789,
      "label": "leukemia"
    },
    {
      "id": 17076,
      "label": "systemic mastocytosis"
    }
  ]
}