{
  "id": 19828,
  "label": "juvenile open angle glaucoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020367",
  "properties": {
    "xrefs": [
      "DOID:1068",
      "GARD:0016883",
      "ICD9:365.14",
      "MEDGEN:453382",
      "MedDRA:10064032",
      "Orphanet:98977",
      "SCTID:71111008",
      "UMLS:C2981140"
    ],
    "synonyms": [
      "JOAG",
      "childhood glaucoma (disease)",
      "glaucoma (disease) of childhood",
      "glaucoma of childhood",
      "juvenile glaucoma",
      "paediatric glaucoma (disease)",
      "pediatric glaucoma (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "Juvenile glaucoma (JG) is a rare autosomal dominant open angle glaucoma, characterized by early onset, severe elevation of intra ocular pressure of rapid progression, leading to optic nerve excavation and, when untreated, substantial visual impairment."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 7024,
      "label": "open-angle glaucoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1067",
          "EFO:0004190",
          "ICD10CM:H40.1",
          "ICD9:365.1",
          "ICD9:365.10",
          "ICD9:365.13",
          "MEDGEN:6611",
          "MESH:D005902",
          "NCIT:C34641",
          "SCTID:46168003",
          "SCTID:84494001",
          "UMLS:C0017612"
        ],
        "synonyms": [
          "POAG",
          "glaucoma, primary open angle",
          "open angle glaucoma",
          "pigmentary glaucoma",
          "primary open angle glaucoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005338"
    },
    {
      "id": 18318,
      "label": "hereditary glaucoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002486",
          "MEDGEN:777991",
          "MESH:C580055",
          "Orphanet:359",
          "UMLS:C3711383"
        ],
        "synonyms": [
          "hereditary glaucoma (disease)",
          "glaucoma, hereditary"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Hereditary glaucoma is a clinically diverse group of rare eye disorders with genetic predisposition characterized by elevated intraocular pressure (IOP) and glaucomatous changes of the optic nerve head, leading to field defects, visual loss and blindness. Hereditary glaucoma can be sub-classified as primary (congenital glaucoma, juvenile glaucoma) or secondary according to the presence or absence of systemic or other ocular anomalies (iridogoniodysgenesis, Stickler syndrome, Coats syndrome). The clinical presentation is variable and is based on age, severity of glaucoma, presence of ocular abnormalities and development of secondary IOP related abnormalities."
      },
      "child_count": 24,
      "reference_id": "MONDO:0018174"
    }
  ],
  "children": [
    {
      "id": 9023,
      "label": "glaucoma 1, open angle, A",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009485",
          "MEDGEN:333974",
          "MESH:C564234",
          "OMIM:137750",
          "UMLS:C1842028"
        ],
        "synonyms": [
          "JOAG1",
          "JOAG1A",
          "MYOC juvenile glaucoma",
          "MYOC juvenile open angle glaucoma",
          "glaucoma 1, open angle, A",
          "glaucoma 1, open angle, type A",
          "glaucoma 1A, primary open angle",
          "juvenile glaucoma caused by mutation in MYOC",
          "juvenile open angle glaucoma caused by mutation in MYOC",
          "GLC1A",
          "glaucoma 1, open angle, 50",
          "glaucoma hereditary, juvenile",
          "glaucoma, primary open angle, juvenile-onset, 1",
          "primary open angle glaucoma juvenile onset 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Any juvenile glaucoma in which the cause of the disease is a mutation in the MYOC gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007664"
    },
    {
      "id": 13167,
      "label": "glaucoma 1, open angle, J",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018228",
          "MEDGEN:324818",
          "MESH:C563874",
          "OMIM:608695",
          "UMLS:C1837528"
        ],
        "synonyms": [
          "GLC1J",
          "JOAG1J",
          "JOAG2",
          "glaucoma 1, open angle, J",
          "glaucoma, primary open angle, juvenile-onset, 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012101"
    },
    {
      "id": 13168,
      "label": "glaucoma 1, open angle, K",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018229",
          "MEDGEN:324817",
          "MESH:C563873",
          "OMIM:608696",
          "UMLS:C1837527"
        ],
        "synonyms": [
          "GLC1K",
          "JOAG1K",
          "glaucoma 1, open angle, K",
          "glaucoma 1K, primary open angle, juvenile-onset",
          "glaucoma, primary open angle, juvenile-onset, 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012102"
    },
    {
      "id": 13563,
      "label": "glaucoma 1, open angle, M",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018230",
          "MEDGEN:400584",
          "MESH:C566436",
          "OMIM:610535",
          "UMLS:C1864653"
        ],
        "synonyms": [
          "GLC1M",
          "JOAG1M",
          "glaucoma 1, open angle, M"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012515"
    },
    {
      "id": 13689,
      "label": "glaucoma 1, open angle, N",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018231",
          "MEDGEN:370756",
          "MESH:C566977",
          "OMIM:611274",
          "UMLS:C1969812"
        ],
        "synonyms": [
          "GLC1N",
          "JOAG1N",
          "glaucoma 1, open angle, N"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012645"
    },
    {
      "id": 24887,
      "label": "glaucoma 1, open angle, l",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026484"
        ],
        "synonyms": [
          "GLC1L"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800210"
    }
  ],
  "roots": [
    {
      "id": 7024,
      "label": "open-angle glaucoma"
    },
    {
      "id": 18318,
      "label": "hereditary glaucoma"
    }
  ]
}