{
  "id": 19830,
  "label": "Chandler syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020369",
  "properties": {
    "xrefs": [
      "DOID:11554",
      "GARD:0006033",
      "MEDGEN:107777",
      "MedDRA:10057487",
      "NORD:918",
      "Orphanet:98979",
      "UMLS:C0544008",
      "icd11.foundation:806443940"
    ],
    "synonyms": [
      "Chandler's Syndrome",
      "Chandler's syndrome",
      "endothelial corneal dystrophy"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "Chandler syndrome, the most frequent clinical variant of iridocorneal endothelial (ICE) syndrome, is characterized by very few iris abnormalities but more severe corneal edema and less severe secondary glaucoma than seen in the other two ICE syndrome variants: Cogan-Reese syndrome and essential iris atrophy."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18261,
      "label": "corneal dystrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3211
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2566",
          "GARD:0027867",
          "HP:0001131",
          "ICD9:371.5",
          "ICD9:371.50",
          "MEDGEN:3619",
          "MESH:D003317",
          "MedDRA:10011005",
          "NCIT:C34513",
          "Orphanet:34533",
          "SCTID:5587004",
          "UMLS:C0010036",
          "icd11.foundation:1291475891"
        ],
        "synonyms": [
          "corneal dystrophy",
          "corneal dystrophy (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "The term corneal dystrophy embraces a heterogeneous group of bilateral genetically determined non-inflammatory corneal diseases that are usually restricted to the cornea. The designation is imprecise but remains in vogue because of its clinical value."
      },
      "child_count": 13,
      "reference_id": "MONDO:0018102"
    },
    {
      "id": 18905,
      "label": "iridocorneal endothelial syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000060",
          "MEDGEN:242751",
          "MESH:D057129",
          "MedDRA:10053678",
          "NCIT:C84792",
          "Orphanet:64734",
          "SCTID:129623003",
          "UMLS:C1096100",
          "icd11.foundation:265074385"
        ],
        "synonyms": [
          "ICE syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Iridocorneal endothelial (ICE) syndrome describes a group of progressive corneal proliferative endotheliopathies comprised of Chandler syndrome, Cogan-Reese syndrome and essential iris atrophy, affecting mainly young adult females and characterized by iris holes and atrophy, papillary distortion, anterior synechiae, corneal edema and often with secondary glaucoma and corneal decompensation as complications"
      },
      "child_count": 3,
      "reference_id": "MONDO:0018988"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18261,
      "label": "corneal dystrophy"
    },
    {
      "id": 18905,
      "label": "iridocorneal endothelial syndrome"
    }
  ]
}