{
  "id": 19936,
  "label": "pituitary gigantism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020479",
  "properties": {
    "xrefs": [
      "GARD:0006506",
      "MEDGEN:6602",
      "MESH:D005877",
      "MedDRA:10018265",
      "NANDO:2100111",
      "NANDO:2200314",
      "NCIT:C93046",
      "Orphanet:99725",
      "SCTID:86073008",
      "UMLS:C0017547"
    ],
    "synonyms": [
      "hypophyseal gigantism",
      "infantile and juvenile forms of acromegaly",
      "gigantism"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "The condition of accelerated and excessive growth in children or adolescents who are exposed to excess human growth hormone before the closure of epiphyses. It is usually caused by somatotroph hyperplasia or a growth hormone-secreting pituitary adenoma. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 8241,
      "label": "hyperpituitarism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21424
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2444",
          "EFO:1000973",
          "ICD9:253.1",
          "MEDGEN:43783",
          "MESH:D006964",
          "MedDRA:10020716",
          "SCTID:10649000",
          "UMLS:C0020506"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006793"
    },
    {
      "id": 19647,
      "label": "growth hormone-producing pituitary gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265,
        17888
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025150",
          "MEDGEN:866320",
          "NCIT:C7911",
          "UMLS:C4018860"
        ],
        "synonyms": [
          "Growth hormone-producing pituitary gland tumor",
          "Growth hormone-producing pituitary gland tumour",
          "growth hormone producing neoplasm of pituitary",
          "growth hormone producing neoplasm of pituitary gland",
          "growth hormone producing neoplasm of the pituitary",
          "growth hormone producing neoplasm of the pituitary gland",
          "growth hormone producing pituitary gland neoplasm",
          "growth hormone producing pituitary gland tumor",
          "growth hormone producing pituitary gland tumour",
          "growth hormone producing pituitary neoplasm",
          "growth hormone producing pituitary tumor",
          "growth hormone producing pituitary tumour",
          "growth hormone producing tumor",
          "growth hormone producing tumor of pituitary",
          "growth hormone producing tumor of pituitary gland",
          "growth hormone producing tumor of the pituitary",
          "growth hormone producing tumor of the pituitary gland",
          "growth hormone producing tumour",
          "growth hormone producing tumour of pituitary",
          "growth hormone producing tumour of pituitary gland",
          "growth hormone producing tumour of the pituitary",
          "growth hormone producing tumour of the pituitary gland",
          "growth hormone secreting neoplasm of pituitary",
          "growth hormone secreting neoplasm of pituitary gland",
          "growth hormone secreting neoplasm of the pituitary",
          "growth hormone secreting neoplasm of the pituitary gland",
          "growth hormone secreting pituitary gland neoplasm",
          "growth hormone secreting pituitary gland tumor",
          "growth hormone secreting pituitary gland tumour",
          "growth hormone secreting pituitary neoplasm",
          "growth hormone secreting pituitary tumor",
          "growth hormone secreting pituitary tumour",
          "growth hormone secreting tumor of pituitary",
          "growth hormone secreting tumor of pituitary gland",
          "growth hormone secreting tumor of the pituitary",
          "growth hormone secreting tumor of the pituitary gland",
          "growth hormone secreting tumour of pituitary",
          "growth hormone secreting tumour of pituitary gland",
          "growth hormone secreting tumour of the pituitary",
          "growth hormone secreting tumour of the pituitary gland",
          "growth hormone-producing pituitary gland neoplasm",
          "pituitary gland somatotropinoma",
          "pituitary somatotropinoma",
          "somatotroph neoplasm",
          "somatotroph tumor",
          "somatotroph tumour",
          "somatotropinoma",
          "somatotropinoma of pituitary",
          "somatotropinoma of pituitary gland",
          "somatotropinoma of the pituitary",
          "somatotropinoma of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces growth hormone."
      },
      "child_count": 6,
      "reference_id": "MONDO:0019927"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 8241,
      "label": "hyperpituitarism"
    },
    {
      "id": 19647,
      "label": "growth hormone-producing pituitary gland neoplasm"
    }
  ]
}