{ "id": 19962, "label": "precursor B-cell acute lymphoblastic leukemia", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0020511", "properties": { "xrefs": [ "DOID:0080638", "GARD:0016920", "ICDO:9836/3", "MEDGEN:83896", "NANDO:2200001", "NANDO:2200022", "NCIT:C8644", "Orphanet:99860", "UMLS:C0349636", "icd11.foundation:1099674056" ], "synonyms": [ "B acute lymphoblastic leukaemia", "B acute lymphoblastic leukemia", "B cell acute lymphocytic leukaemia", "B cell acute lymphocytic leukemia", "B-ALL", "B-cell acute lymphoblastic leukaemia", "B-cell acute lymphoblastic leukemia", "B-cell acute lymphocytic leukaemia", "B-cell acute lymphocytic leukemia", "B-cell lymphoblastic leukaemia", "B-cell lymphoblastic leukemia", "B-cell type acute leukaemia", "B-cell type acute leukemia", "acute B cell lymphocytic leukaemia", "acute B cell lymphocytic leukemia", "acute B-cell lymphocytic leukaemia", "acute B-cell lymphocytic leukemia", "B cell precursor type acute leukaemia", "B cell precursor type acute leukemia", "B-cell precursor type acute leukaemia", "B-cell precursor type acute leukemia", "B-precursor ALL", "precursor B-cell acute lymphoblastic leukemia/lymphoma", "precursor B-cell acute lymphocytic leukaemia", "precursor B-cell acute lymphocytic leukemia", "precursor B-cell acute lymphocytic leukemia/lymphoma", "precursor B-lymphoblastic leukaemia", "precursor B-lymphoblastic leukaemia (B-precursor ALL)", "precursor B-lymphoblastic leukemia", "precursor B-lymphoblastic leukemia (B-precursor ALL)" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "The most frequent type of acute lymphoblastic leukemia. Approximately 75% of cases occur in children under six years of age. This is a good prognosis leukemia. In the pediatric age group the complete remission rate is approximately 95% and the disease free survival rate is 70%. Approximately 80% of children appear to be cured. In the adult age group the complete remission rate is 60-85%. (WHO, 2001)" }, "isLeaf": false, "isRoot": false, "child_count": 2, "parents": [ { "id": 6710, "label": "acute lymphoblastic leukemia", "isLeaf": false, "isRoot": false, "parents": [ 5444, 6890, 7079, 11789, 18836 ], "type_id": 0, "properties": { "xrefs": [ "DOID:9952", "EFO:0000220", "GARD:0000522", "HP:0006721", "ICD10CM:C91.0", "ICD9:204", "ICD9:204.0", "ICD9:204.00", "ICD9:204.9", "ICDO:9835/3", "MEDGEN:7317", "NCIT:C3167", "Orphanet:513", "SCTID:91857003", "UMLS:C0023449" ], "synonyms": [ "lymphoblastic leukaemia", "lymphoblastic leukemia", "ALL", "ALL - acute lymphocytic leukaemia", "ALL - acute lymphocytic leukemia", "acute lymphoblastic leukaemia (ALL)", "acute lymphoblastic leukaemia (disease)", "acute lymphoblastic leukemia", "acute lymphoblastic leukemia (ALL)", "acute lymphoblastic leukemia (disease)", "acute lymphoblastic leukemia/lymphoma", "acute lymphocytic leukaemia", "acute lymphocytic leukemia", "acute lymphocytic leukemias", "acute lymphogenous leukaemia", "acute lymphogenous leukemia", "acute lymphoid leukaemia", "acute lymphoid leukemia", "leukemia, lymphoblastic, malignant", "lymphoblastic leukemia, acute", "precursor Lymphoblasic leukaemia", "precursor Lymphoblasic leukemia", "precursor cell lymphoblastic leukaemia", "precursor cell lymphoblastic leukemia", "precursor lymphoblastic leukaemia", "precursor lymphoblastic leukemia" ], "categories": [ { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia." }, "child_count": 60, "reference_id": "MONDO:0004967" }, { "id": 17875, "label": "aggressive B-cell non-Hodgkin lymphoma", "isLeaf": false, "isRoot": false, "parents": [ 16516 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0021245", "MEDGEN:1791561", "NCIT:C178541", "Orphanet:300846", "UMLS:C5555120" ], "synonyms": [ "aggressive B-cell NHL" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ] }, "child_count": 6, "reference_id": "MONDO:0017595" } ], "children": [ { "id": 3142, "label": "B-cell adult acute lymphocytic leukemia", "isLeaf": true, "isRoot": false, "parents": [ 5446, 19962 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0060592", "EFO:1001935", "GARD:0022832", "MEDGEN:79010", "NCIT:C9143", "UMLS:C0279593" ], "synonyms": [ "B acute lymphoblastic leukaemia", "B acute lymphoblastic leukemia", "B cell adult ALL", "B cell adult acute lymphoblastic leukaemia", "B cell adult acute lymphoblastic leukemia", "B cell adult acute lymphocytic leukaemia", "B cell adult acute lymphocytic leukemia", "B-cell adult ALL", "B-cell adult acute lymphoblastic leukaemia", "B-cell adult acute lymphoblastic leukemia", "B-cell childhood acute lymphoblastic leukaemia of adults", "B-cell childhood acute lymphoblastic leukemia of adults", "adult B acute lymphoblastic leukemia", "adult B cell ALL", "adult B cell acute lymphoblastic leukaemia", "adult B cell acute lymphoblastic leukemia", "adult B cell acute lymphocytic leukaemia", "adult B cell acute lymphocytic leukemia", "adult B-cell ALL", "adult B-cell acute lymphoblastic leukemia", "adult B-cell acute lymphocytic leukaemia", "adult B-cell acute lymphocytic leukemia", "adult B-cell childhood acute lymphoblastic leukaemia", "adult B-cell childhood acute lymphoblastic leukemia", "adult precursor B-lymphoblastic leukaemia", "adult precursor B-lymphoblastic leukemia" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "An acute B-lymphoblastic leukemia occurring in adults." }, "child_count": 0, "reference_id": "MONDO:0000814" }, { "id": 3162, "label": "B-cell childhood acute lymphoblastic leukemia", "isLeaf": true, "isRoot": false, "parents": [ 3028, 3160, 19962 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080146", "EFO:1001946", "GARD:0022835", "MEDGEN:83526", "NANDO:2200002", "NCIT:C9140", "UMLS:C0279584" ], "synonyms": [ "B acute lymphoblastic leukaemia", "B acute lymphoblastic leukemia", "B cell childhood ALL", "B cell childhood acute lymphoblastic leukaemia", "B cell childhood acute lymphoblastic leukemia", "B cell childhood acute lymphocytic leukaemia", "B cell childhood acute lymphocytic leukemia", "B cell paediatric ALL", "B cell paediatric acute lymphoblastic leukaemia", "B cell paediatric acute lymphocytic leukaemia", "B cell pediatric ALL", "B cell pediatric acute lymphoblastic leukemia", "B cell pediatric acute lymphocytic leukemia", "B-cell childhood ALL", "B-cell childhood acute lymphocytic leukaemia", "B-cell childhood acute lymphocytic leukemia", "B-cell childhood acute lymphogenous leukaemia", "B-cell childhood acute lymphogenous leukemia", "B-cell childhood acute lymphoid leukaemia", "B-cell childhood acute lymphoid leukemia", "B-cell paediatric ALL", "B-cell paediatric acute lymphoblastic leukaemia", "B-cell paediatric acute lymphocytic leukaemia", "B-cell paediatric acute lymphogenous leukaemia", "B-cell paediatric acute lymphoid leukaemia", "B-cell pediatric ALL", "B-cell pediatric acute lymphoblastic leukemia", "B-cell pediatric acute lymphocytic leukemia", "B-cell pediatric acute lymphogenous leukemia", "B-cell pediatric acute lymphoid leukemia", "childhood B acute lymphoblastic leukaemia", "childhood B acute lymphoblastic leukemia", "childhood B-ALL", "childhood precursor B-lymphoblastic leukaemia", "childhood precursor B-lymphoblastic leukemia" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "An acute B-lymphoblastic leukemia occurring in children." }, "child_count": 0, "reference_id": "MONDO:0000872" } ], "roots": [ { "id": 6710, "label": "acute lymphoblastic leukemia" }, { "id": 17875, "label": "aggressive B-cell non-Hodgkin lymphoma" } ] }