{
  "id": 19965,
  "label": "thymic neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020516",
  "properties": {
    "xrefs": [
      "GARD:0019696",
      "MEDGEN:900590",
      "NCIT:C171031",
      "Orphanet:99869",
      "SCTID:716653001",
      "UMLS:C2210965",
      "icd11.foundation:381956131"
    ],
    "synonyms": [
      "neuroendocrine carcinoma of thymus",
      "thymic neuroendocrine carcinoma",
      "thymus neuroendocrine carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Thymic neuroendocrine carcinoma is a type of thymic epithelial neoplasm displaying evidence of neuroendocrine differentiation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 7956,
      "label": "thymic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4646,
        6734,
        18240
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3284",
          "DOID:4554",
          "EFO:1000576",
          "GARD:0019695",
          "ICDO:8586/3",
          "MEDGEN:60049",
          "MedDRA:10061031",
          "NANDO:2200079",
          "NCIT:C7569",
          "NCIT:C7612",
          "ONCOTREE:THYC",
          "Orphanet:99868",
          "SCTID:444374006",
          "UMLS:C0205969",
          "icd11.foundation:1351671383"
        ],
        "synonyms": [
          "carcinoma of thymus",
          "malignant thymoma",
          "thymic carcinoma",
          "thymic carcinoma (excluding well differentiated thymic carcinoma)",
          "thymic carcinoma excluding well differentiated thymic carcinoma",
          "thymoma type C",
          "thymoma, malignant",
          "thymoma, malignant (morphologic abnormality)",
          "thymoma, type C (morphologic abnormality)",
          "thymus carcinoma",
          "type C thymoma",
          "THYC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Thymic carcinoma (TC) is a type of thymic epithelial neoplasm characterized by a high malignant potential."
      },
      "child_count": 27,
      "reference_id": "MONDO:0006451"
    },
    {
      "id": 19679,
      "label": "thymic neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6916,
        19314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019361",
          "MEDGEN:234428",
          "NCIT:C6430",
          "ONCOTREE:TNET",
          "Orphanet:97289",
          "UMLS:C1336746"
        ],
        "synonyms": [
          "neuroendocrine neoplasm of thymus",
          "thymus NET",
          "thymus neuroendocrine neoplasm",
          "thymus neuroendocrine tumor",
          "thymus neuroendocrine tumor, well differentiated, low or intermediate grade",
          "thymus neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Thymic endocrine tumor is a rare, malignant, primary thymic neoplasm originating from neuroendocrine cells, presenting as a mass within the anterior mediastinum. Patients typically present with nonspecific symptoms, such as chest pain, cough, shortness of breath, or in some cases, superior vena cava syndrome, although patients could be asymptomatic during the early stages or present with multiple endocrine neoplasia type I. Ectopic production of ACTH and serotonin can lead to Cushing syndrome and carcinoid sydrome, respectively."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019964"
    }
  ],
  "children": [
    {
      "id": 5038,
      "label": "thymic large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6787,
        19965
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4553",
          "GARD:0023344",
          "MEDGEN:235250",
          "NCIT:C6461",
          "UMLS:C1334364"
        ],
        "synonyms": [
          "large cell neuroendocrine carcinoma of Thymus",
          "large cell neuroendocrine carcinoma of the Thymus",
          "large cell neuroendocrine carcinoma of thymus",
          "thymic LCNEC",
          "thymic large cell neuroendocrine carcinoma",
          "thymus large cell carcinoma",
          "thymus large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An aggressive, non-small cell, poorly differentiated thymic neuroendocrine carcinoma, characterized by the presence of a high mitotic rate and, almost always, necrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003047"
    },
    {
      "id": 5952,
      "label": "thymus small cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        19965
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7142",
          "EFO:1000578",
          "GARD:0023835",
          "MEDGEN:234784",
          "NCIT:C6460",
          "UMLS:C1335980"
        ],
        "synonyms": [
          "Thymus small cell carcinoma",
          "small cell carcinoma of Thymus",
          "small cell carcinoma of the Thymus",
          "small cell carcinoma of thymus",
          "thymic small cell carcinoma",
          "thymic small cell carcinoma neuroendocrine type",
          "thymus small cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An aggressive, small cell, poorly differentiated thymic neuroendocrine carcinoma, characterized by the presence of a high mitotic rate and numerous apoptotic bodies."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004122"
    },
    {
      "id": 17388,
      "label": "well-differentiated thymic neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19965
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020895",
          "MEDGEN:931134",
          "Orphanet:263331",
          "SCTID:717922007",
          "UMLS:C4305465",
          "icd11.foundation:2004515128"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016976"
    },
    {
      "id": 17389,
      "label": "moderately-differentiated thymic neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19965
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020896",
          "MEDGEN:1843377",
          "Orphanet:263335",
          "UMLS:C5680730",
          "icd11.foundation:1165208895"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016977"
    },
    {
      "id": 17390,
      "label": "poorly differentiated thymic neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19965
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020897",
          "MEDGEN:931135",
          "Orphanet:263339",
          "SCTID:717921000",
          "UMLS:C4305466"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016978"
    }
  ],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 7956,
      "label": "thymic carcinoma"
    },
    {
      "id": 19679,
      "label": "thymic neuroendocrine tumor"
    }
  ]
}