{
  "id": 19966,
  "label": "eosinophilic granuloma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020517",
  "properties": {
    "xrefs": [
      "GARD:0025166",
      "ICD9:277.89",
      "ICDO:9752/1",
      "MEDGEN:4979",
      "MESH:D004803",
      "MedDRA:10014956",
      "NCIT:C3016",
      "Orphanet:99871",
      "SCTID:129000002",
      "UMLS:C0014461",
      "icd11.foundation:1377407737"
    ],
    "synonyms": [
      "Monostotic Langerhans cell histiocytosis",
      "chronic and localised Langerhans cell histiocytosis",
      "chronic and localized Langerhans cell histiocytosis",
      "chronic unifocal Langerhans cell histiocytosis",
      "eosinophilic granuloma",
      "eosinophilic xanthomatous granuloma",
      "unifocal Langerhans cell histiocytosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A clinical variant of Langerhans cell histiocytosis characterized by unifocal involvement of a bone (most often), skin, or lung. Patients are usually older children or adults usually presenting with a lytic bone lesion. The etiology is unknown. Morphologically, eosinophilic granuloma is characterized by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophils, neutrophils, and small, mature lymphocytes."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6815,
      "label": "respiratory system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1579",
          "EFO:0000684",
          "ICD10CM:J00-J99",
          "ICD9:460-519",
          "ICD9:500-508",
          "ICD9:503",
          "ICD9:508",
          "ICD9:508.1",
          "ICD9:508.8",
          "ICD9:508.9",
          "ICD9:510-519",
          "ICD9:516",
          "ICD9:516.8",
          "ICD9:516.9",
          "ICD9:517",
          "ICD9:517.8",
          "ICD9:519",
          "ICD9:519.1",
          "ICD9:519.3",
          "ICD9:519.8",
          "ICD9:519.9",
          "ICD9:V12.60",
          "ICD9:V47.2",
          "MEDGEN:48421",
          "MESH:D012140",
          "NANDO:1100010",
          "NCIT:C26871",
          "SCTID:50043002",
          "UMLS:C0035204"
        ],
        "synonyms": [
          "disease of respiratory system",
          "disease or disorder of respiratory system",
          "disorder of respiratory system",
          "respiratory disease",
          "respiratory disorder",
          "respiratory system disease",
          "respiratory system disease or disorder",
          "respiratory system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma."
      },
      "child_count": 59,
      "reference_id": "MONDO:0005087"
    },
    {
      "id": 18407,
      "label": "Langerhans cell histiocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4688,
        6569,
        19729,
        21541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2571",
          "EFO:1000318",
          "GARD:0006858",
          "ICD9:202.5",
          "ICD9:277.89",
          "ICDO:9751/1",
          "ICDO:9751/3",
          "ICDO:9752/1",
          "ICDO:9753/1",
          "ICDO:9754/3",
          "MEDGEN:5568",
          "MedDRA:10069698",
          "NANDO:2200031",
          "NCIT:C3107",
          "NORD:1348",
          "OMIM:604856",
          "ONCOTREE:LCH",
          "Orphanet:389",
          "SCTID:65399007",
          "UMLS:C0019621",
          "icd11.foundation:1388720498",
          "icd11.foundation:216625985"
        ],
        "synonyms": [
          "LCH",
          "Langerhans cell granulomatosis",
          "Langerhans cell histiocytosis",
          "Langerhans cell histiocytosis, NOS",
          "Langerhans cell histiocytosis, Not otherwise specified",
          "histiocytosis X",
          "Langerhans-cell histiocytosis",
          "Lch"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues."
      },
      "child_count": 32,
      "reference_id": "MONDO:0018310"
    }
  ],
  "children": [
    {
      "id": 19969,
      "label": "adult pulmonary Langerhans cell histiocytosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17422,
        19966
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025167",
          "ICD10CM:J84.82",
          "MEDGEN:853967",
          "NCIT:C142833",
          "Orphanet:99874",
          "SCTID:328611000119105",
          "UMLS:C3161104",
          "icd11.foundation:792398738"
        ],
        "synonyms": [
          "PLCH",
          "pulmonary Langerhans cell histiocytosis",
          "pulmonary eosinophilic granuloma",
          "pulmonary histiocytosis X"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Adult pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare histiocytic lung disease characterized by the accumulation of Langerhans and other inflammatory cells in the small airways, resulting in the formation of nodular inflammatory lesions."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020520"
    }
  ],
  "roots": [
    {
      "id": 6815,
      "label": "respiratory system disorder"
    },
    {
      "id": 18407,
      "label": "Langerhans cell histiocytosis"
    }
  ]
}