{
  "id": 19969,
  "label": "adult pulmonary Langerhans cell histiocytosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020520",
  "properties": {
    "xrefs": [
      "GARD:0025167",
      "ICD10CM:J84.82",
      "MEDGEN:853967",
      "NCIT:C142833",
      "Orphanet:99874",
      "SCTID:328611000119105",
      "UMLS:C3161104",
      "icd11.foundation:792398738"
    ],
    "synonyms": [
      "PLCH",
      "pulmonary Langerhans cell histiocytosis",
      "pulmonary eosinophilic granuloma",
      "pulmonary histiocytosis X"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Adult pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare histiocytic lung disease characterized by the accumulation of Langerhans and other inflammatory cells in the small airways, resulting in the formation of nodular inflammatory lesions."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17422,
      "label": "Langerhans cell histiocytosis specific to adulthood",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17421,
        18407,
        20356
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025086",
          "MEDGEN:859694",
          "NANDO:2200031",
          "NCIT:C114929",
          "Orphanet:264750",
          "UMLS:C3900100"
        ],
        "synonyms": [
          "Langerhans cell histiocytosis",
          "Langerhans cell granulomatosis specific to adulthood",
          "adult Langerhans cell histiocytosis",
          "histiocytosis X specific to adulthood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Langerhans cell histiocytosis that occurs during adulthood."
      },
      "child_count": 3,
      "reference_id": "MONDO:0017029"
    },
    {
      "id": 19966,
      "label": "eosinophilic granuloma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6815,
        18407
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025166",
          "ICD9:277.89",
          "ICDO:9752/1",
          "MEDGEN:4979",
          "MESH:D004803",
          "MedDRA:10014956",
          "NCIT:C3016",
          "Orphanet:99871",
          "SCTID:129000002",
          "UMLS:C0014461",
          "icd11.foundation:1377407737"
        ],
        "synonyms": [
          "Monostotic Langerhans cell histiocytosis",
          "chronic and localised Langerhans cell histiocytosis",
          "chronic and localized Langerhans cell histiocytosis",
          "chronic unifocal Langerhans cell histiocytosis",
          "eosinophilic granuloma",
          "eosinophilic xanthomatous granuloma",
          "unifocal Langerhans cell histiocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clinical variant of Langerhans cell histiocytosis characterized by unifocal involvement of a bone (most often), skin, or lung. Patients are usually older children or adults usually presenting with a lytic bone lesion. The etiology is unknown. Morphologically, eosinophilic granuloma is characterized by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophils, neutrophils, and small, mature lymphocytes."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020517"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17422,
      "label": "Langerhans cell histiocytosis specific to adulthood"
    },
    {
      "id": 19966,
      "label": "eosinophilic granuloma"
    }
  ]
}