{
  "id": 19975,
  "label": "ACTH-dependent Cushing syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020528",
  "properties": {
    "xrefs": [
      "DOID:3946",
      "EFO:1001110",
      "GARD:0019699",
      "ICD10CM:E24.0",
      "MEDGEN:575036",
      "MESH:D047748",
      "MedDRA:10035109",
      "Orphanet:99892",
      "SCTID:190502001",
      "SCTID:237734007",
      "UMLS:C0342442",
      "icd11.foundation:212778081"
    ],
    "synonyms": [
      "ACTH-dependent CS",
      "adrenocorticotropic hormone-dependent Cushing syndrome",
      "corticotropin-dependent Cushing syndrome",
      "pituitary-dependent Cushing's disease",
      "ACTH hypersecretion, pituitary",
      "adrenocorticotropic hormone, inappropriate secretion",
      "pituitary Cushing disease",
      "pituitary Cushing diseases",
      "pituitary Cushing syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A group of endogenous Cushing syndrome caused by abnormal production of ACTH due to pituitary adenoma or an extrapituitary tumor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 8241,
      "label": "hyperpituitarism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21424
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2444",
          "EFO:1000973",
          "ICD9:253.1",
          "MEDGEN:43783",
          "MESH:D006964",
          "MedDRA:10020716",
          "SCTID:10649000",
          "UMLS:C0020506"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006793"
    },
    {
      "id": 25672,
      "label": "endogenous Cushing syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7151,
        18839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026827",
          "MEDGEN:1727013",
          "Orphanet:641613",
          "UMLS:C5419158"
        ],
        "synonyms": [
          "endogenous CS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any Cushing syndrome caused by body's prolonged overproduction of cortisol that can be dependent on or independent of adrenocorticotropic hormone (ACTH)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0957431"
    }
  ],
  "children": [
    {
      "id": 10301,
      "label": "Cushing disease due to pituitary adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5357,
        18043,
        19975,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7004",
          "GARD:0012867",
          "MEDGEN:66381",
          "MESH:D049913",
          "MedDRA:10035109",
          "NANDO:1200379",
          "NANDO:2200350",
          "NCIT:C113210",
          "OMIM:219090",
          "Orphanet:96253",
          "SCTID:254958004",
          "UMLS:C0221406",
          "icd11.foundation:380861892"
        ],
        "synonyms": [
          "ACTH producing pituitary adenoma",
          "Cushing disease",
          "Cushing disease, pituitary",
          "Cushing's disease",
          "PITA4",
          "corticotroph pituitary adenoma",
          "pituitary adenoma 4, ACTH-secreting",
          "pituitary adenoma 4, ACTH-secreting, somatic",
          "pituitary adenoma, ACTH-secreting",
          "pituitary corticotroph micro-adenoma",
          "pituitary dependent Cushing syndrome",
          "pituitary-dependent Cushing syndrome",
          "ACTH-secreting pituitary adenoma",
          "Corticotropinoma",
          "corticotroph adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome, an endogenous Cushing syndrome (CS), characterized by chronic over-secretion of adrenocorticotropic hormone (ACTH) due to a pituitary corticotroph adenoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009050"
    },
    {
      "id": 19974,
      "label": "ectopic Cushing syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19975
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060890",
          "GARD:0019698",
          "Orphanet:99889",
          "icd11.foundation:1646144829"
        ],
        "synonyms": [
          "Cushing syndrome due to ectopic ACTH secretion",
          "adrenocorticotropic hormone secretion syndrome",
          "ectopic ACTH secreting tumor",
          "ectopic ACTH secreting tumour",
          "ectopic Cushing syndrome",
          "occult ectopic ACTH secretion",
          "paraneoplastic Cushing syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of ACTH-dependent Cushing syndrome caused by excess secretion of ACTH by a benign or, more often, malignant non-pituitary tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020527"
    }
  ],
  "roots": [
    {
      "id": 8241,
      "label": "hyperpituitarism"
    },
    {
      "id": 25672,
      "label": "endogenous Cushing syndrome"
    }
  ]
}