{
  "id": 19976,
  "label": "ACTH-independent Cushing syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020529",
  "properties": {
    "xrefs": [
      "GARD:0019700",
      "MEDGEN:575037",
      "Orphanet:647758",
      "Orphanet:99893",
      "UMLS:C0342443",
      "icd11.foundation:652536990"
    ],
    "synonyms": [
      "adrenal Cushing syndrome",
      "adrenocorticotropic hormone-independent Cushing syndrome",
      "corticotropin-independent Cushing syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A group of endogenous Cushing syndrome  that may result from excess secretion of cortisol by either a unilateral and benign, or malignant adrenocortical tumor, or nodular adrenocortical disease."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 25672,
      "label": "endogenous Cushing syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7151,
        18839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026827",
          "MEDGEN:1727013",
          "Orphanet:641613",
          "UMLS:C5419158"
        ],
        "synonyms": [
          "endogenous CS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any Cushing syndrome caused by body's prolonged overproduction of cortisol that can be dependent on or independent of adrenocorticotropic hormone (ACTH)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0957431"
    }
  ],
  "children": [
    {
      "id": 10300,
      "label": "Cushing syndrome due to macronodular adrenal hyperplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        19976
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111622",
          "EFO:0009041",
          "GARD:0010824",
          "MEDGEN:923388",
          "MESH:C565662",
          "NANDO:2200353",
          "OMIMPS:219080",
          "Orphanet:189427",
          "SCTID:720459002",
          "UMLS:C2062388"
        ],
        "synonyms": [
          "ACTH-independent Cushing syndrome",
          "ACTH-independent macronodular adrenal hyperplasia",
          "primary bilateral macronodular adrenal hyperplasia",
          "ACTH-independent macronodular adrenocortical hyperplasia",
          "AIMAH",
          "MMAD",
          "adrenocorticotropic hormone-independent macronodular adrenal hyperplasia",
          "corticotropin-independent macronodular adrenal hyperplasia",
          "massive macronodular adrenocortical disease",
          "primary macronodular adrenal hyperplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare adrenal Cushing syndrome characterized by bilateral benign adrenal macronodules (>1 cm) that potentially produce autonomously variable levels of cortisol excess. Although in most cases are ACTH-independent, non-suppressed ACTH levels have been described."
      },
      "child_count": 6,
      "reference_id": "MONDO:0009049"
    },
    {
      "id": 24966,
      "label": "ACTH-independent adrenal Cushing syndrome, somatic",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19976
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026535"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800377"
    },
    {
      "id": 25899,
      "label": "Cushing syndrome due to cortisol-producing adrenocortical adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19976
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026988",
          "MEDGEN:1853161",
          "Orphanet:642788",
          "UMLS:C5816799"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of endogenous Cushing syndrome characterized by chronic over-secretion of cortisol due to a benign adrenal tumor that arises from the adrenal cortex."
      },
      "child_count": 0,
      "reference_id": "MONDO:0958258"
    }
  ],
  "roots": [
    {
      "id": 25672,
      "label": "endogenous Cushing syndrome"
    }
  ]
}