{
  "id": 19985,
  "label": "maligant granulosa cell tumor of ovary",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020541",
  "properties": {
    "xrefs": [
      "GARD:0019707",
      "MEDGEN:138043",
      "NCIT:C8403",
      "Orphanet:99915",
      "SCTID:254861002",
      "UMLS:C0346175",
      "icd11.foundation:148207042"
    ],
    "synonyms": [
      "adult ovarian granulosa cell tumor",
      "adult ovarian granulosa cell tumour",
      "cancer of granulosa cell",
      "granulosa cell cancer",
      "granulosa cell malignant tumor",
      "granulosa cell malignant tumour",
      "malignant granulosa cell neoplasm",
      "malignant granulosa cell neoplasm of ovary",
      "malignant granulosa cell neoplasm of the ovary",
      "malignant granulosa cell tumor of ovary",
      "malignant granulosa cell tumor of the ovary",
      "malignant granulosa cell tumour of ovary",
      "malignant granulosa cell tumour of the ovary",
      "malignant ovarian granulosa cell neoplasm",
      "malignant ovarian granulosa cell tumor",
      "malignant ovarian granulosa cell tumour",
      "ovarian granulosa cell tumor of adults",
      "ovarian granulosa cell tumour of adults",
      "GCT of the ovary",
      "GTCT",
      "Maligant granulosa cell tumor of the ovary",
      "Maligant granulosa cell tumour of the ovary",
      "adult granulosa cell tumor of the ovary",
      "adult granulosa cell tumour of the ovary",
      "granulosa theca cell tumor",
      "granulosa theca cell tumor of the ovary",
      "granulosa theca cell tumour",
      "granulosa theca cell tumour of the ovary"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An aggressive granulosa cell tumor that arises from the ovary and metastasizes to other anatomic sites."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18316,
      "label": "malignant sex cord stromal tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18448,
        20709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018816",
          "MEDGEN:233667",
          "NCIT:C8053",
          "Orphanet:35808",
          "UMLS:C1334609"
        ],
        "synonyms": [
          "malignant Sex cord-stromal tumor of ovary",
          "malignant Sex cord-stromal tumor of the ovary",
          "malignant Sex cord-stromal tumour of ovary",
          "malignant Sex cord-stromal tumour of the ovary",
          "malignant ovarian SCST",
          "malignant ovarian Sex cord-stromal neoplasm",
          "malignant ovarian Sex cord-stromal tumor",
          "malignant ovarian Sex cord-stromal tumour",
          "malignant ovarian sex cord-stromal tumor",
          "malignant ovarian sex cord-stromal tumour",
          "ovarian sex cord-stromal tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant sex cord stromal tumor (SCST) of ovary is a rare ovarian cancer arising from granulosa, theca, sertoli and leydig cells or stromal fibroblasts, occurring at any age and presenting with abdominal or pelvic mass, and characterized (with the exception of fibroma) by the production of sex steroids resulting in manifestations of hormone excess, with a relatively favorable prognosis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018172"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:170",
          "ICD9:194.9",
          "MEDGEN:56319",
          "MESH:D004701",
          "NCIT:C3575",
          "UMLS:C0153658"
        ],
        "synonyms": [
          "endocrine neoplasm",
          "Endocrine tumour",
          "cancer of endocrine gland",
          "endocrine cancer",
          "endocrine gland cancer",
          "endocrine neoplasm, malignant",
          "malignant endocrine gland neoplasm",
          "malignant endocrine gland tumor",
          "malignant endocrine gland tumour",
          "malignant endocrine neoplasm",
          "malignant endocrine tumor",
          "malignant endocrine tumour",
          "malignant neoplasm of endocrine gland",
          "malignant neoplasm of the endocrine gland",
          "malignant tumor of endocrine gland",
          "malignant tumor of the endocrine gland",
          "malignant tumour of the endocrine gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0021069"
    },
    {
      "id": 21206,
      "label": "ovarian granulosa cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7622,
        20709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027911",
          "MEDGEN:277970",
          "MESH:C537296",
          "NCIT:C6261",
          "SCTID:254863004",
          "UMLS:C1370419"
        ],
        "synonyms": [
          "granulosa cell neoplasm of ovary",
          "granulosa cell neoplasm of the ovary",
          "granulosa cell tumor of ovary",
          "granulosa cell tumor of the ovary",
          "granulosa cell tumour of ovary",
          "granulosa cell tumour of the ovary",
          "ovarian granulosa cell neoplasm",
          "ovarian granulosa cell tumor",
          "ovary granulosa cell tumor",
          "ovary granulosa cell tumour",
          "GCT of the ovary",
          "adult granulosa cell tumor of the ovary",
          "adult granulosa cell tumour of the ovary",
          "granulosa theca cell tumor",
          "granulosa theca cell tumor of the ovary",
          "granulosa theca cell tumour",
          "granulosa theca cell tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0023283"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18316,
      "label": "malignant sex cord stromal tumor of ovary"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm"
    },
    {
      "id": 21206,
      "label": "ovarian granulosa cell tumor"
    }
  ]
}